Antiplatelet (aspirin) therapy as a new option in the treatment of vasculogenic erectile dysfunction: a prospective randomized double-blind placebo-controlled study

Bayraktar, Zeki; Albayrak, Selami

doi:10.1007/s11255-018-1786-0

Cited by 18 publications

(41 citation statements)

References 29 publications

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“…Of the remaining 20 articles, 6 were excluded with different reasons, which included unable to obtain the related data distribution in cases and controls, data not qualified (controls having ED). Finally, the remaining 14 studies (Akbas et al, ; Aldemir et al, ; Aldemir et al, ; Bayraktar & Albayrak, ; Ciftci et al, ; Ciftci et al, ; El Taieb, Hegazy, Maklad, & Khairy, ; Guo et al, ; Guo et al, ; La Vignera et al, ; Otunctemur et al, ; Sambel et al, ; Senturk et al, ; Wang et al, ) were enrolled in our systematic review and meta‐analysis, all of which were identified as case–control studies. No further articles were identified for inclusion through the repeated cited reference screening.…”

Section: Resultsmentioning

confidence: 99%

“…Thirteen studies reporting the PLT levels in ED (1580 subjects) and non‐ED cases (977 subjects) were included in the meta‐analysis (Akbas et al, ; Aldemir et al, ; Aldemir et al, ; Bayraktar & Albayrak, ; Ciftci et al, ; Ciftci et al, ; El Taieb et al, ; Guo et al, ; Guo et al, ; Otunctemur et al, ; Sambel et al, ; Senturk et al, ; Wang et al, ). The pooled SMD indicated that individuals with ED had about 0.215 k/μl higher of PLT levels than those without ED (SMD [95% CI] = 0.215 [0.133–0.297], p = 0.000), with severe heterogeneity existed ( I 2 = 90.1%).…”

Section: Resultsmentioning

confidence: 99%

“…Thirteen articles (Aldemir et al, ; Aldemir et al, ; Bayraktar & Albayrak, ; Ciftci et al, ; Ciftci et al, ; El Taieb et al, ; Guo et al, ; Guo et al, ; Otunctemur et al, ; Sambel et al, ; Senturk et al, ; Wang et al, ) with data consisting of MPV level in individuals with ED (1595 subjects) vs. without ED (967 subjects) were included in the final data analysis. The overall SMD indicated that cases with ED had higher MPV level than those in controls (overall, SMD [95% CI] = 0.651 [0.567–0.735], p = 0.000), still with severe heterogeneity (92.5%).…”

Section: Resultsmentioning

confidence: 99%

“…Along with this same line, tadalafil has induced a beneficial impact on platelet activation in ED patients without cardiovascular risk factors, including an increase in platelet cAMP and a decrease in P‐selection levels (De Bon, Bonanni, Saggiorato, Bassi, & Cella, ). Antiplatelet (aspirin) therapy has shown to be a promising treatment option in vasculogenic ED in patients with high MPV levels (Bayraktar & Albayrak, ), which shed valuable light on antiplatelet as a novel treatment strategy for ED in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

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Platelet indices and erectile dysfunction: A systematic review and meta‐analysis

Yang

Muzepper

2019

Andrologia

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Elevated platelet levels have been postulated to be associated with cardiovascular diseases, conditions closely linked to erectile dysfunction (ED). The current systematic review and meta‐analysis was performed to assess the platelet indices, which including platelet count (PLT), mean platelet volume (MPV) and platelet distribution width (PDW) in subjects with ED compared to controls in an attempt to clarify the possible role of platelet indices in the pathogenesis of ED. We initially screened the candidate studies observing the possible association between platelet indices and ED following literature search of database Cochrane Library, PubMed, EMBASE and MEDLINE and therefore included the studies based on the pre‐defined inclusion and exclusion criteria. Two independent investigators extracted the related information on article data and outcome measures from the qualified studies, and a meta‐analysis was therefore performed using Stata 12.0 software. Subgroup analyses were conducted by the different ED aetiology obtained from the eligible studies. The standard mean difference (SMD) and the corresponding 95% confidence intervals (95% CIs) were applied to estimate the outcome measures. A total of 14 articles were qualified in our meta‐analysis with a total of 1595 cases and 987 controls included. Pooled estimate was in favour of increased MPV levels in subjects with ED with a SMD of 0.651 fl, 95% CI 0.567–0.735, p = 0.000. Subgroup analysis showed that vasculogenic ED had a higher MPV levels than controls as well (SMD [95% CI] = 1.026 [0.823–1.228], p = 0.000). However, pooled analysis based on PLT and PDW levels has produced inconsistent results and not strong evidence on platelet level and ED correlation. In conclusion, vasculogenic ED patients had a higher MPV level in our study. However, the results need further interpretation with caution and more high‐quality studies are warranted.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Platelet indices and erectile dysfunction: A systematic review and meta‐analysis

Yang

Muzepper

2019

Andrologia

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“…В экспериментальном исследовании противовоспалительный препарат (ацетилсалициловая кислота) оказывал протективный эффект в отношении ЭД у крыс с диабетом [7]. По крайней мере в одном исследовании с участием людей прием препаратов ацетилсалициловой кислоты повышал индекс эректильной функции у мужчин с васкулогенной ЭД [8].…”

Section: научный обзорunclassified

Male health and obesity – diagnostic and therapeutic approach

Гамидов¹,

Shatylko²,

Гасанов³

2019

Obes. metabol.

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Obesity may present as a significant medical problem for any person, regardless of age or gender. In men obesity causes considerable psychological stress, sexual dysfunction, subfertility, hypogonadism and cardiovascular conditions. These problems may form numerous pathological associations between each other, creating a vicious circle. The main factors which influence male fertility and sexual function in obesity and metabolic syndrome are imbalance of sex hormones and systemic inflammation. In many patients symptomatic treatment is necessary for above-mentioned manifestations, but it is always rational to act on their pathophysiology and to recommend to lower the body mass by diet and lifestyle modification. When it proves impossible for the patient to follow such recommendations and when behavioral approach fails, central-acting and peripheral-acting medications may be used, including orlistat, sibutramine and liraglutide. Bariatric surgery should be offered to patients with high body mass index in whom conservative management fails. Without elimination of excess body mass it is difficult to solve problems regarding sexual dysfunction, hypogonadism and subfertility in obese males. All these issues and available modes of pharmacological treatment are described in this review.

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Efficacy and safety of combination of tadalafil and aspirin versus tadalafil or aspirin alone in patients with vascular erectile dysfunction: a comparative randomized prospective study

Bayraktar

Albayrak

2019

Int Urol Nephrol

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Antiplatelet (aspirin) therapy as a new option in the treatment of vasculogenic erectile dysfunction: a prospective randomized double-blind placebo-controlled study

Abstract: 100 mg of aspirin administered once a day significantly improved EF in men with VED.

Cited by 18 publications

References 29 publications

Platelet indices and erectile dysfunction: A systematic review and meta‐analysis

Platelet indices and erectile dysfunction: A systematic review and meta‐analysis

Male health and obesity – diagnostic and therapeutic approach

Efficacy and safety of combination of tadalafil and aspirin versus tadalafil or aspirin alone in patients with vascular erectile dysfunction: a comparative randomized prospective study

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