Antiplatelet Aggregation Constituents from Annona purpurea

Abstract

Bioactivity-directed fractionation led to the isolation of 19 compounds, including three oxoaporphines, oxopurpureine (5), oxonuciferine (6), and oxoglaucine (7); three aporphines, (+)-predicentrine (8), (-)-glaucine (9), and thalbaicalidine (10); one aporphine sensu stricto, N-formyl-purpureine (11); one proaporphine, glaziovine; one phenanthrene, thalicpureine (12); two 6a,7-dehydroaporphines, dehydrolirinidine (13) and 7-hydroxy-dehydroglaucine (14); four flavonoids, quercetin-3-O-rhamnoside, kaempferol-3-O-rhamnoside, isorhamnetin-3-O-rhamnoside, and tanarixetin-3-O-rhamnoside; one purine, adenine; one lactam amide, squamolone; and two steroids, beta-sitosterol and beta-sitosterol-beta-D-glucoside from the MeOH extract of the leaves of Formosan Annona purpurea. Among them, 11-14 were characterized as new compounds and alkaloids, 5-8, 10, and 12-14 exhibited significant antiplatelet aggregation activity.

Chemical structure of flavonols in relation to modulation of angiogenesis and immune-endothelial cell adhesion

“…Several biological activities have been attributed to kaempferol, including inhibition of lipoxygenase and cyclooxygenase [23,24]. It also possesses antiaggregatory [25], antibacterial [26] and anticancer [27] activities. Galangin (Fig.…”

Photochemistry of Phytoalexins Containing Phenalenone‐like Chromophores: Photophysics and Singlet Oxygen Photosensitizing Properties of the Plant Oxoaporphine Alkaloid Oxoglaucine¶

“…Oxoglaucine (OG; Fig. 1) is an oxoaporphine alkaloid that has been isolated from overground parts of plants belonging to different families such as Annonaceae (1, 2), Lauraceae (3), Magnoliaceae (4), Fumariaceae (5, 6), Menispermaceae (7) and Papaveraceae (8, 9). Especially interesting is the case of Magnoliaceae, in which OG is present in injured plants but absent in healthy ones (4).…”

Alkaloids from Xylopia parvifolia and Xylopia nigricans (Annonaceae)

“…The family Annonaceae is important phytochemically because of the frequent presence of isoquinoline alkaloids and, more recently on the basis of the restrictive occurrence of a very active class of natural products, the acetogenins 1 . It comprises 130 genera and some 2300 species 2 .…”