Antiplatelet Aggregation Activity of 5-Hydroxyflavone, 2’- Hydroxyflavanone, Paeonol and Bergenin Isolated from Stem Bark of Garcinia malaccensis in Human Whole Blood

Abstract

The plant kingdom has served as one of man's oldest sources of useful drugs. They are remarkable in their ability to produce a vast number of diverse secondary metabolites ranging in chemical complexity and biological activities. Natural products (NPs) have historically served as templates for the modern drug development. The Garcinia species are known to be rich in

A Fresh Look on Bergenin: Vision of Its Novel Drug Delivery Systems and Pharmacological Activities

“…Alkadi and his research team isolated four known constituents, 5-Hydroxyflavone, 2 -Hydroxyflavanone, Paeonol, and BER, from the stem bark of Garciniamalaccensis. All isolated components were found to exhibit the prevention of platelet aggregation in human blood, stimulated by collagen, ADP (adenosine diphosphate), and AA (arachidonic acid) [3].…”

“…Plants are incredible in their potential to generate a huge number of specialized metabolites and byproducts with different biological actions. Natural constituents have been used as models for the development of drugs [3] and provided unquestionable support for human welfare [4]. Bergenin (BER) is a natural constituent, which has been extracted from various parts (rhizome, roots, leaves, stem, barks, aerials, seeds, cortex, flowers, wood, tuber, heartwood, fruit or whole plant) of plants [5] such as Bergenia crassifolia (B. crassifolia), Bergenia ciliata (Saxifragaceae), Corylopsis spicata (C. spicata), Mallotus philippinensis (M. philippinensis), Caesalpinia digyna (C. digyna), Sacoglottis gabonensis (S. gabonensis), and Mallotus japonicus (M. japonicus) (Table 1 and Figure 1).…”

Diversity, pharmacology and synthesis of bergenin and its derivatives: Potential materials for therapeutic usages

“…Bergenin (1) inhibited platelet aggregation in human blood [86]. It showed marked inhibitory effect caused by the three inducers arachidonic acid (IC 50 = 240.6 μM), adenosine diphosphate (IC 50 = 120.3 μM) and collagen (IC 50 = 60.9 μM).…”

“…Bergenin esters (21,22,26,27,77,(86)(87)(88)(89) were prepared by Kashima and Miyazawa (Fig. 12), and their mushroom tyrosinase inhibitory and antioxidant activities were reported [40].…”

Vasorelaxant and Antihypertensive Effects of Bergenin on Isolated Rat Aorta and High Salt-Induced Hypertensive Rats

“…Bergenin is reported for several biological activities, including antiulcer [ 10 ], antiplatelet [ 11 ], antioxidant [ 12 ], antiarthritic [ 13 ], anti-inflammatory activity [ 13 , 14 ], and hypolipidemic activities [ 15 ]. However, bergenin is not investigated as an antihypertensive agent.…”