Antiplatelet activity of aporphine and phenanthrenoid alkaloids from <i>Aromadendron elegans</i> blume

Jantan, Ibrahim; Raweh, Salwa M.; Yasin, Yusyila Harlina Mohd; Murad, Shahnaz

doi:10.1002/ptr.1885

Cited by 27 publications

(17 citation statements)

References 26 publications

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“…The mean platelet aggregation in whole blood was measured as a change in impedance over 6 min after the addition of the inducers by comparison with that of a control group impedance. The final concentration of DMSO in the whole blood was 0.5% to eliminate the effect of the solvent on the aggregation (Jantan et al, 2006). Aspirin was used as a positive control.…”

Section: Platelet Aggregationmentioning

confidence: 99%

Biological activities of the hydro-alchoholic and aqueous extracts of Achillea biebersteinii Afan. (Asteraceae) grown in Jordan

Hammad¹

2013

Afr. J. Pharm. Pharmacol.

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Aqueous and hydro-alcoholic extracts of Achillea biebersteinii Afan. (Asteraceae) grown in Jordan were screened for their antioxidant, antibacterial and antiplatelet efficacy. Total phenols and flavonoids were determined colorimetrically. The radical scavenging activities were evaluated using 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS) radical scavenging activity assays. Antimicrobial activities were determined by the disc-diffusion method, and the minimum inhibition concentration and the minimum bactericidal concentration tests. Gram positive bacteria presented sensitivity to the hydro-alcoholic extract in the disk diffusion test. No significant activity was observed against Gram negative bacteria and Candida albicans. Hydro-alcoholic extract had a bactericidal activity against Streptococcus pneumoniae, Bacillus cereus, Enterococcus faecalis and Klebsiella pneumoniae rather than inhibitory effect. In vitro antiplatelet activity was determined with human whole blood using an electrical impedance method. At concentrations (50, 100, and 200 μg/ml), the extracts showed a non-dose dependent enhancement of platelet aggregation induced by adenosine diphosphate (ADP) (51.82, 52.73 and 51.82%, respectively) and collagen (0.00, 11.76 and 23.53%, respectively). High performance liquid chromatography-mass spectrometry (HPLC-MS) analysis resulted in the identification of 8 phenolic compounds; quercetin 3-β-D-glucoside was the main component.

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Section: Platelet Aggregationmentioning

confidence: 99%

Biological activities of the hydro-alchoholic and aqueous extracts of Achillea biebersteinii Afan. (Asteraceae) grown in Jordan

Hammad¹

2013

Afr. J. Pharm. Pharmacol.

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“…The primary screening results reveal that oxoglaucine possesses strong anticancer activity, such as against HCT-8 (ED 50 = 1.00 µg/ml) and K B (ED 50 = 2.00 µg/ml) (Chang et al, 2002;Chen et al, 2002;Wu et al, 1989). In addition, oxoglaucine exhibits other important pharmacological activities including antiplatelet aggregation (Chang et al, 1998;Jantan et al, 2006), immunomodulatory activity (Ivanovska et al, 1997 and2000), treatment of adjuvant arthritis , antiinflammatory (Remichkova et al, 2009), antifungal activity (Clark et al, 1987). Fig.…”

Section: Oxoglaucine-metal Based Anticancer Agentsmentioning

confidence: 99%

Traditional Chinese Medicine Active Ingredient-Metal Based Anticancer Agents

Chen¹,

Liang²,

Liu³

2012

Recent Advances in Theories and Practice of Chinese Medicine

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“…Various isoquinoline alkaloids are used as traditional medicines in the Orient because of their immunomodulatory, antiinflammatory and antibacterial effects (Brezová et al, 2004;Jantan et al, 2006). In addition, they decrease the activity of elastase reductions in which are known to be associated with inflammatory disease and the development of arthritis (Tanaka et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

Antiinflammatory effect of the ethanol extract of Berberis koreana in a gerbil model of cerebral ischemia/reperfusion

Yoo

Hwang

Kim

et al. 2008

Phytotherapy Research

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Berberis koreana extract (BE) has a strong neuroprotective effect after ischemic stroke in gerbils, which is associated with the inhibition of the N-methyl-d-aspartate receptor. The present study examined the antiinflammatory mechanism of BE after ischemic damage in vitro and in vivo. The BE used contained on average 7.39 +/- 0.78 mg/g of berberine. In PC12 cells with inflammation, prostaglandin E2 (PGE2) production was significantly reduced by BE. About 75% of pyramidal cells in the hippocampal CA1 region of gerbils exposed to 5 min of transient ischemia were protected from ischemic damage by BE. Cyclooxygenase-2 (COX-2) immunoreactivity and its protein level in the CA1 region of vehicle-treated animals exposed to an ischemic insult increased with time post-ischemia, whereas no such changes were observed in BE-treated animals exposed to ischemia. PGE2 production in BE-treated ischemic animals was significantly lower than that observed in vehicle-treated ischemic animals. Summarizing, the potent neuroprotective effect of BE was found to be due to the inhibitions of COX-2 expression and PGE2 production and its antiinflammatory activity.

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Antiplatelet activity of aporphine and phenanthrenoid alkaloids from Aromadendron elegans blume

Cited by 27 publications

References 26 publications

Biological activities of the hydro-alchoholic and aqueous extracts of Achillea biebersteinii Afan. (Asteraceae) grown in Jordan

Biological activities of the hydro-alchoholic and aqueous extracts of Achillea biebersteinii Afan. (Asteraceae) grown in Jordan

Traditional Chinese Medicine Active Ingredient-Metal Based Anticancer Agents

Antiinflammatory effect of the ethanol extract of Berberis koreana in a gerbil model of cerebral ischemia/reperfusion

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