Antiplasmodial Securinega alkaloids from Phyllanthus fraternus: Discovery of natural (+)-allonorsecurinine

Komlaga, Gustav; Genta‐Jouve, Grégory; Cojean, Sandrine; Dickson, Rita A.; Mensah, Merlin Lincoln Kwao; Loiseau, Philippe M.; Champy, Pierre; Beniddir, Mehdi A.

doi:10.1016/j.tetlet.2017.08.045

Cited by 21 publications

(20 citation statements)

References 23 publications

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“…Five securinega alkaloids including (+)-allonorsecurinine ( 75 ), ent-norsecurinine ( 76 ), nirurine ( 77 ), bubbialine ( 78 ), and epibubbialine ( 79 ) ( Figure 4 ) were isolated from P. fraternus G.L. Webster [ 37 ].…”

Section: Chemical Componentsmentioning

confidence: 99%

Chemical Components and Biological Activities of the Genus Phyllanthus: A Review of the Recent Literature

Nisar

Ahmed

et al. 2018

Molecules

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Medicinal plants have served humans since prehistoric times to treat various ailments. Both developed and underdeveloped countries rely on traditional systems of medication using natural sources from plants. Phyllanthus is one of the largest genus in the family Phyllanthaceae, comprising over 700 well known species cosmopolitan in distribution mainly in the tropics and subtropics. Phyllanthus species are being in constant used in traditional medications to cure an array of human diseases (constipation, inhalation related, arthritis, loss of appetite, injuries, conjunctivitis, diarrhoea, running nose, common cold, malaria, blennorrhagia, colic, diabetes mellitus, dysentery, indigestion, fever, gout, gonorrheal diseases of males and females, skin itching, jaundice, hepatic disorders, leucorrhea, vaginitis, menstrual irregularities, obesity, stomach pains, and tumors), confectionaries, food industry, and in some pesticides. Phyllanthus species are rich in diversity of phytochemicals e.g., tannins, terpenes, alkaloids, glycosidic compounds, saponins, and flavones etc. More in depth studies are a direly needed to identify more compounds with specific cellular functions to treat various ailments.

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Section: Chemical Componentsmentioning

confidence: 99%

Chemical Components and Biological Activities of the Genus Phyllanthus: A Review of the Recent Literature

Nisar

Ahmed

et al. 2018

Molecules

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“…Antiplasmodial Assay: The antimalarial activity of extracts/compounds was evaluated against P. falciparum 3D7 and P. falciparum W2 strains, using the fluorescence-based SYBR Green I assay approach in 96-well microplates as described by Smilkstein et al, 8 with some modifications. Positive control wells for each assay contained no inhibitor while negative controls contained chloroquine (CQ).…”

Section: Extraction and Fractionationmentioning

confidence: 99%

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2018

IJPSR

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“…Acylation of the sodium salts of 3 with phenoxyacetyl chlorides 4 in CH2Cl2 at 0 °C furnished compounds 5 (85-90%). Final deprotection [34,35] of 5 using trifluoroacetic acid at room temperature provided compounds 6a-b (50-95%) (Scheme 1).…”

Section: Chemistrymentioning

confidence: 99%

“…The condensation of 7 with the phenol 8 gave compounds 9 (78-80%). Final deprotection [34,35] of 9 using…”

Section: Scheme 1 Synthesis Of Compounds 6a-bmentioning

confidence: 99%

Synthesis and Antimalarial Activity of 1,4-Disubstituted Piperidine Derivatives

et al. 2020

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In order to prepare, at low cost, new compounds active against Plasmodium falciparum, and with a less side-effects, we have designed and synthesized a library of 1,4-disubstituted piperidine derivatives from 4-aminopiperidine derivatives 6. The resulting compound library has been evaluated against chloroquine-sensitive (3D7) and chloroquine-resistant (W2) strains of P. falciparum. The most active molecules—compounds 12d (13.64 nM (3D7)), 13b (4.19 nM (3D7) and 13.30 nM (W2)), and 12a (11.6 nM (W2))—were comparable to chloroquine (22.38 nM (3D7) and 134.12 nM (W2)).

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Antiplasmodial Securinega alkaloids from Phyllanthus fraternus: Discovery of natural (+)-allonorsecurinine

Cited by 21 publications

References 23 publications

Chemical Components and Biological Activities of the Genus Phyllanthus: A Review of the Recent Literature

Chemical Components and Biological Activities of the Genus Phyllanthus: A Review of the Recent Literature

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Synthesis and Antimalarial Activity of 1,4-Disubstituted Piperidine Derivatives

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