Antiplasmodial phloroglucinol derivatives from Syncarpia glomulifera

Su, Qingxi; Dalal, Seema; Goetz, Michael; Cassera, María B.; Kingston, David G. I.

doi:10.1016/j.bmc.2016.04.020

Cited by 13 publications

(8 citation statements)

References 23 publications

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“…The combinations of 35 µg/mL luteolin-5- O -β-d-glucoside and 5 µg/mL verbenoside, and 25 µg/mL luteolin-5- O -β-d-glucoside and 10 μg/mL verbenoside had the strongest antagonistic effects. 30 The antiedematogenic 31 and antiplasmodial 32 activities of betulinic acid, and the antioxidant activity of quercetin 3- O -rhamnoside 33, 34 have been reported in medical herbs, but showed no significant effect in the present study.…”

Section: Discussioncontrasting

confidence: 51%

Experimental Study on the Inhibition of Bacteria and Algae by Jussiaea stipulacea Ohwi Extract

Shi

Zheng

Bing

et al. 2022

Natural Product Communications

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Nowadays, plant allelopathy, as a new type of biological algal and/or bacterial inhibition technology, has attracted extensive attention. Eight substances were isolated and identified from Jussiaea stipulacea Ohwi, and five concentration gradients, as well as a control (0, 1.25, 5, 10, 20, and 50 mg/L) were set, with three parallels in each group, and then sampled and detected at 24, 48, 72, and 96 h. When the concentration was 50 mg/L, the inhibition rate of Anabaena was as high as 74.8%, 69.2%, and 70.7% for ursolic acid, kaempferol, and luteolin, respectively. Streptococcus iniae and Aeromonas hydrophila were cultured to a logarithmic phase, and their final concentrations reached 1000, 500, 250, 125, 62.50, 31.25, 15.63, and 7.81 μg/mL. Luteolin and gallic acid showed an inhibitory effect on S iniae and A hydrophila at 1000 μg/mL. We found that allelochemicals also had a certain bacteriostatic effect, among which luteolin has great development potential.

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Section: Discussioncontrasting

confidence: 51%

Experimental Study on the Inhibition of Bacteria and Algae by Jussiaea stipulacea Ohwi Extract

Shi

Zheng

Bing

et al. 2022

Natural Product Communications

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“…A new phloroglucinol β-triketone rhodomyrtosone F ( 380 ) (Fig. 51) from Syncarpia glomulifera (Myrtaceae) stem bark extract, displayed sub-micromolar inhibition of Dd2 P. falciparum and only inhibited HEK293 cells by 58% at 50 µM, suggesting selective toxicity to parasites [235]. Likewise, rhodomyrtone ( 381 ), from the flower extract of Angophora woodsiana (Myrtaceae), was active against 3D7 and Dd2 parasites but moderately cytotoxic [236].…”

Section: Polyphenolsmentioning

confidence: 99%

Antiplasmodial natural products: an update

Tajuddeen

Heerden

2019

Malar J

122

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BackgroundMalaria remains a significant public health challenge in regions of the world where it is endemic. An unprecedented decline in malaria incidences was recorded during the last decade due to the availability of effective control interventions, such as the deployment of artemisinin-based combination therapy and insecticide-treated nets. However, according to the World Health Organization, malaria is staging a comeback, in part due to the development of drug resistance. Therefore, there is an urgent need to discover new anti-malarial drugs. This article reviews the literature on natural products with antiplasmodial activity that was reported between 2010 and 2017.MethodsRelevant literature was sourced by searching the major scientific databases, including Web of Science, ScienceDirect, Scopus, SciFinder, Pubmed, and Google Scholar, using appropriate keyword combinations.Results and DiscussionA total of 1524 compounds from 397 relevant references, assayed against at least one strain of Plasmodium, were reported in the period under review. Out of these, 39% were described as new natural products, and 29% of the compounds had IC50 ≤ 3.0 µM against at least one strain of Plasmodium. Several of these compounds have the potential to be developed into viable anti-malarial drugs. Also, some of these compounds could play a role in malaria eradication by targeting gametocytes. However, the research into natural products with potential for blocking the transmission of malaria is still in its infancy stage and needs to be vigorously pursued.

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“…It is interesting to note that a number of phloroglucinol derivatives reportedly possess antiparasitic activity. (±)-Rhodomyrtosone F from Syncarpia glomulifera (Myrtaceae), mallatojaponin C from Mallotus oppositifolius (Euphorbiaceae), and tomentosone A from Rhodomyrtus tomentosa (Myrtaceae) are examples of antiplasmodial phloroglucinol derivatives, while antileishmanial activity has been described for lindbergins E and F from Elaphoglossum lindbergii (Dryopteridaceae), and spiranthenones A and B from Spiranthera odoratissima (Rutaceae) …”

Section: Resultsmentioning

confidence: 99%

HPLC-Based Activity Profiling for Antiprotozoal Compounds in the Endemic Iranian Medicinal Plant Helichrysum oocephalum

et al. 2019

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In a screening of Iranian plants for antiprotozoal activity a dichlomethane extract from the aerial parts of Helichrysum oocephalum showed in vitro antiprotozoal activity against Plasmodium falciparum and Leishmania donovani, with IC 50 values of 4.01 ± 0.50 and 5.08 ± 0.07 μg/mL, respectively. The activity in the extract was tracked by HPLC-based activity profiling, and subsequent targeted preparative isolation afforded 24 compounds, including pyrones 22−24, phloroglucinol derivatives 12−19, and compounds containing both structural motifs (1−11, 20, and 21). Of these, 15 compounds were new natural products. The in vitro antiprotozoal activity of isolates was determined. Compound 3 showed good potency and selectivity in vitro against L. donovani (IC 50 1.79 ± 0.17 μM; SI 53).

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Antiplasmodial phloroglucinol derivatives from Syncarpia glomulifera

Cited by 13 publications

References 23 publications

Experimental Study on the Inhibition of Bacteria and Algae by Jussiaea stipulacea Ohwi Extract

Experimental Study on the Inhibition of Bacteria and Algae by Jussiaea stipulacea Ohwi Extract

Antiplasmodial natural products: an update

HPLC-Based Activity Profiling for Antiprotozoal Compounds in the Endemic Iranian Medicinal Plant Helichrysum oocephalum

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