Antiplasmodial compounds from the stem bark of Neoboutonia macrocalyx pax

Namukobe, Jane; Kiremire, Bernard T.; Boyer, Robert; Kasenene, John; Akala, Hoseah M.; Kamau, Edwin; Dumontet, Vincent

doi:10.1016/j.jep.2014.12.018

Cited by 10 publications

(6 citation statements)

References 30 publications

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“…It also had a resistance index of 4.69 showing that it was less reactive to the CQ Dd2 resistance strain compared to the ethyl acetate crude extract which had a value of 0.34. These results are similar to those in which the activity of the pure compounds was higher than the crude extracts conducted in an investigation [36]. They evaluated the ethyl acetate and aqueous extracts of Neoboutonia macrocalyx against CQ sensitive (D6) and CQ resistant (W2) strains of P. falciparum.…”

Section: Antiplasmodial Activity Of Crude Extracts and Pure Compoundssupporting

confidence: 80%

In vitro Antiplasmodial and Toxicity Activities of Crude Extracts and Compounds from Euclea latideus (Ebenaceae)

Philip¹,

Elizabeth²,

Cheplogoi³

et al. 2018

IJBCRR

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Aims:In our search for new antiplasmodial agents, in vitro antiplasmodial activities of the crude extracts and isolated pure compounds were determined. In addition to the in vitro assays, in vivo acute toxicity of the crude extracts was investigated to assess the safety of the plants. Furthermore, structure elucidation of the pure compounds was also carried out to determine the identity of the isolated compounds. Study Design: Extraction of the root crude extracts of Euclea latideus was done using four solvents: hexane, dichloromethane, ethyl acetate and methanol. Isolation and purification were Original Research Article

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Section: Antiplasmodial Activity Of Crude Extracts and Pure Compoundssupporting

confidence: 80%

In vitro Antiplasmodial and Toxicity Activities of Crude Extracts and Compounds from Euclea latideus (Ebenaceae)

Philip¹,

Elizabeth²,

Cheplogoi³

et al. 2018

IJBCRR

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“…On the other hand, otostegindiol (25, 50, and 100 mg/kg) against Plasmodium berghei exhibited a significant chemosuppression effect (Endale et al, 2013). It should be mentioned that, till date, a number of promising diterpenes and their derivatives have been isolated from natural sources (Pouvelle et al, 1994;Uys et al, 2002;Riel et al, 2002;Kuria et al, 2002;Köhler et al, 2002;Clarkson et al, 2003;Wei et al, 2004;Loyola et al, 2004;Ospina et al, 2005;Kalauni et al, 2006;Ojo-Amaize et al, 2007;Koka et al, 2009;Lane et al, 2009;Wei et al, 2010;Lin et al, 2010;Wangchuk et al, 2010;Stout et al, 2010;Sebisubi et al, 2010;Stout et al, 2011;Cocquyt et al, 2011;Alasbahi and Melzig, 2012;Ebrahimi et al, 2013;Ehrhardt et al, 2013;Walter et al, 2013;Batista et al, 2013;González et al, 2014;Ma et al, 2014;Avilés et al, 2015;Gbedema et al, 2015;Annan et al, 2015;Sadashiva et al, 2015;Namukobe et al, 2015;Ahmad et al, 2016).…”

Section: Resultsmentioning

confidence: 99%

“…In some studies, diterpenes in nanoformulations (Roy et al, 2010;Mondal et al, 2013) as well as their laboratory derivatives have been reported to exhibit promising anti-NTDs activities (Watson and Preedy, 2010;Mander and Liu, 2010). Additionally, a number of diterpenes have been reported to act against multiple strains responsible for a particular NTD (Sanchez et al, 2006;Dea-Ayuela et al, 2016;Johnson et al, 1993;Riel et al, 2002;Clarkson et al, 2003;Kalauni et al, 2006;Ojo-Amaize et al, 2007;Wangchuk et al, 2010;González et al, 2014;Namukobe et al, 2015;Liu et al, 1997;Prabu et al, 2015;Encarnación-Dimayuga et al, 2006;Rijo et al, 2010;Arai et al, 2014;Xu et al, 2014a;Xu et al, 2014b) and NTDs (Schmidt et al, 2011;Al Musayeib et al, 2014;Ramírez-Macías et al, 2012;Mothana et al, 2014;Falodun et al, 2014;Mizuno et al, 2015;Mongkolvisut and Sutthivaiyakit, 2007;Rangkaew et al, 2009;Ospina and Rodríguez, 2009;Lekphrom et al, 2010;Almutairi et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Diterpenes as lead molecules against neglected tropical diseases

et al. 2016

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Nowadays, neglected tropical diseases (NTDs) are reported to be present everywhere. Poor and developing areas in the world have received great attention to NTDs. Drug resistance, safety profile, and various challenges stimulate the search for alternative medications. Plant-based drugs are viewed with great interest, as they are believed to be devoid of side effects. Diterpenes, a family of essential oils, have showed attractive biological effects. A systematic review of the literature was carried out to summarize available evidences of diterpenes against NTDs. For this, databases were searched using specific search terms. Among the 2338 collected reports, a total of 181 articles were included in this review. Of them, 148 dealt with investigations using single organisms, and 33 used multiple organisms. No mechanisms of action were reported in the case of 164 reports. A total of 93.92% were related to nonclinical studies, and 4.42% and 1.66% dealt with preclinical and clinical studies, respectively. The review displays that many diterpenes are effective upon Chagas disease, chikungunya, echinococcosis, dengue, leishmaniasis, leprosy, lymphatic filariasis, malaria, schistosomiasis, and tuberculosis. Indeed, diterpenes are amazing drug candidates against NTDs. Copyright © 2016 John Wiley & Sons, Ltd.

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“…The crude DCM extract was tested for its antiplasmodial activity against D6 malaria parasite strains (Table 3). Antiplasmodial activity of the crude extracts and isolated compounds was classified as follows; extracts with IC50 < 5 µg/mL were highly active, IC50 between 5-15 µg/mL were moderately active and promising, low activity at IC50 between 15-50 µg/mL and inactive at IC50>50 µg/mL (Batista et al, 2009;Namukobe et al, 2015). Basing on the above classification, the MeOH crude extract was moderately active against D6 (IC50= 5.45 µg/mL) and W2 (IC50 = 12.34 µg/mL) malaria strains.…”

Section: Antiplasmodial Activity Of the Crude Extract And Isolated Comentioning

confidence: 99%

Bioactive secondary metabolites from the leaves of <I>Secamone africana</I> (Olive.) Bullock

Sekandi¹,

Namukobe²,

Boyer³

et al. 2020

Int. J. Bio. Chem. Sci

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Secamone africana leaves are used in the treatment of malaria and other ailments in Uganda. The aim of the study was to characterize the antiplasmodial compounds from the leaves of Secamone africana. The leaves were extracted sequentially using dichloromethane (DCM) and methanol (MeOH). The crude extracts and isolated compounds were evaluated for their antiplasmodial activity against the chloroquine sensitive Sierraleone I (D6) and chloroquine-resistant Indochina I (W2) strains of Plasmodium falciparum. Isolation and purification were done using chromatographic techniques including column chromatography and high performance liquid chromatography. The isolated compounds were characterized using spectroscopic methods. The MeOH extract (IC50 = 5.45 μg/mL) was found to be more active than the DCM extract (IC50= 15.93 μg/mL) against the D6 malaria parasite. Chemical investigation of the MeOH extract yielded one new compound; 2-(2,4-dimethyloxetan-2-yl) acetic acid (3) in addition to the six known compounds; α-linolenic acid (1), conduritol B (4), β-sitosterol (5), 3,4-dihydroxybenzoic acid (6), 4-hydroxybenzoic acid (7) and coumaric acid (8). The DCM extract yielded one known compound: 1-methyl cyclobutene (2). The presence of these compounds with good anti-plasmodial activities and other bioactivities reported in literature, appears to argue for the therapeutic potential of Secamone africana.Keywords: Secamone africana,, anti-plasmodial activity, chromatography, secondary metabolites.

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Antiplasmodial compounds from the stem bark of Neoboutonia macrocalyx pax

Cited by 10 publications

References 30 publications

In vitro Antiplasmodial and Toxicity Activities of Crude Extracts and Compounds from Euclea latideus (Ebenaceae)

In vitro Antiplasmodial and Toxicity Activities of Crude Extracts and Compounds from Euclea latideus (Ebenaceae)

Diterpenes as lead molecules against neglected tropical diseases

Bioactive secondary metabolites from the leaves of <I>Secamone africana</I> (Olive.) Bullock

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