Antiplasmodial and Cytotoxic Dibenzofurans from Preussia sp. harboured in Enantia chlorantha Oliv

Talontsi, Ferdinand Mouafo; Lamshöft, Marc; Douanla‐Meli, Clovis; Kouam, Siméon F.; Spiteller, Michael

doi:10.1016/j.fitote.2014.01.003

Cited by 34 publications

(22 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This allowed concluding that the isolates could be alkaloids. This information is correlating with the literature review [16] [17]. Table 1 shows the CC 50 in CC 50 /mL obtained from the five bark extracts of A. chlorantha comparatively to the positive control-drug Paclitaxel.…”

Section: Resultssupporting

confidence: 74%

In Vitro Anticancer Assessment of Annickia chlorantha (Oliv.) Setten & Maas Stem (Annonaceae) Bark from Democratic Republic of Congo

Tshibangu¹,

Selvaraj²,

Ramanathan³

et al. 2016

JBM

View full text Add to dashboard Cite

In this study, we evaluated the anti-cancer property of five bark extracts and the isolates from chloroform and ethyl acetate of Annickia chlorantha by the tetrazolium salt method (MTT method). The anti-cancer activity was performed on human prostate cancer cell lines PC-3 and hormone-dependent breast cancer cell lines MCF-7. Results indicated that the two isolates displayed interesting cytotoxicity towards MCF-7 cell lines with CC 50 of 3.84 CC 50 /mL and 4.87 CC 50 /mL for chloroform and ethyl acetate respectively; while the total bark extracts showed CC 50 of 24.33 CC 50 /mL, 36.49 CC 50 / mL and 73.52 CC 50 /mL for chloroform, ethyl acetate and methanol extracts respectively. By the other hand on PC-3, the CC 50 of the isolates were higher than the one on MCF-7, more than 10 CC 50 /mL for both chloroform and ethyl acetate isolates and 49.14 CC 50 /mL, 77.33 CC 50 /mL, 89.38 CC 50 /mL and 92.37 CC 50 /mL, respectively for chloroform, ethyl acetate and methanol soluble extracts. From this study, we identified that the two isolates had anti-cancer properties against MCF-7 cell lines.

show abstract

Section: Resultssupporting

confidence: 74%

In Vitro Anticancer Assessment of Annickia chlorantha (Oliv.) Setten & Maas Stem (Annonaceae) Bark from Democratic Republic of Congo

Tshibangu¹,

Selvaraj²,

Ramanathan³

et al. 2016

JBM

View full text Add to dashboard Cite

show abstract

“…Antiplasmodial activity was also reported for compounds 15a and 15b against a chloroquine-resistante P. falciparum (NF54). They showed modest activity against erythrocyte stages of this strain with IC 50 values of 8.76 and 15.0 µg/mL respectively, in comparison with chloroquine (0.002 µg/mL) 47 .…”

Section: Antiplasmodial Activitymentioning

confidence: 92%

“…Cultured mycobionts of various lichens led to ascomatate derivatives 1c-1e 19,[40][41][42] and dibenzofurans 8a, 8b, 9a-9e [43][44] . Other dibenzofurans and derivatives are produced by two marine fungi 10 45 and 11a-11c 46 , one endophytic fungus (15a-15b) 47 or Aspergillus sp. (12a-12b 48 and 9a, 13 49 53,[17][18][20][21][22][23][24] -dibenzofurans bearing aliphatic chain(s) (4), mainly described in the genera Cladonia and also from Roccella hypomecha; 33-37, 54 30 -dibenzofurans with a lactone ring (5-7) resulted from the cyclization of the carboxylic function in C2 8,10 and found in numerous genera such as Letrouitia, Phyllospora, or Alectoria.…”

Section: Biogenesis and Sourcesmentioning

confidence: 99%

Dibenzofurans and derivatives from lichens and ascomycetes

2016

View full text Add to dashboard Cite

Covering: up to 2016.When looking for dibenzofuran in the biochemical databases, most papers and reviews deal with pollutants and polychlorinated dibenzofurans like dioxins. But dibenzofurans are also biosynthetized by a wide diversity of organisms in nature. Even if dibenzofurans from natural sources represent a small class of secondary metabolites, compared to flavonoids, xanthones or terpenoids, they are often endowed with interesting biological properties which have been recently described. This review provides an update on papers describing dibenzofurans from lichens, ascomycetes and cultured mycobionts. Other sources, such as basidiomycetes, myxomycetes or plants produce sporadically interesting dibenzofurans in terms of structures and activities.

show abstract

“…is a new Chinese strain discovered in 2013 and belongs to endophytic fungi. Its isolates have strong antiplasmodial, antibacterial, and antioxidant activities 120,121 . Harmonema dematioides is also an endophytic fungus.…”

Section: Preussia Sp and Harmonema Dematioidesmentioning

confidence: 99%

An overview on natural farnesyltransferase inhibitors for efficient cancer therapy

Dai

Sun

Zhang

et al. 2020

Journal of Enzyme Inhibition and Medicinal Chemistry

View full text Add to dashboard Cite

As one of the world's five terminally ills, tumours can cause important genetic dysfunction. However, some current medicines for tumours usually have strong toxic side effects and are prone to drug resistance. Studies have found that farnesyltransferase inhibitors (FTIs) extracted from natural materials have a good inhibiting ability on tumours with fewer side effects. This article describes several FTIs extracted from natural materials and clarifies the current research progress, which provides a new choice for the treatment of tumours.

show abstract

Antiplasmodial and Cytotoxic Dibenzofurans from Preussia sp. harboured in Enantia chlorantha Oliv

Cited by 34 publications

References 17 publications

<i>In Vitro</i> Anticancer Assessment of <i>Annickia chlorantha</i> (Oliv.) Setten & Maas Stem (Annonaceae) Bark from Democratic Republic of Congo

<i>In Vitro</i> Anticancer Assessment of <i>Annickia chlorantha</i> (Oliv.) Setten & Maas Stem (Annonaceae) Bark from Democratic Republic of Congo

Dibenzofurans and derivatives from lichens and ascomycetes

An overview on natural farnesyltransferase inhibitors for efficient cancer therapy

Contact Info

Product

Resources

About

Antiplasmodial and Cytotoxic Dibenzofurans from Preussia sp. harboured in Enantia chlorantha Oliv

Cited by 34 publications

References 17 publications

&lt;i&gt;In Vitro&lt;/i&gt; Anticancer Assessment of &lt;i&gt;Annickia chlorantha&lt;/i&gt; (Oliv.) Setten &amp; Maas Stem (Annonaceae) Bark from Democratic Republic of Congo

&lt;i&gt;In Vitro&lt;/i&gt; Anticancer Assessment of &lt;i&gt;Annickia chlorantha&lt;/i&gt; (Oliv.) Setten &amp; Maas Stem (Annonaceae) Bark from Democratic Republic of Congo

Dibenzofurans and derivatives from lichens and ascomycetes

An overview on natural farnesyltransferase inhibitors for efficient cancer therapy

Contact Info

Product

Resources

About

<i>In Vitro</i> Anticancer Assessment of <i>Annickia chlorantha</i> (Oliv.) Setten & Maas Stem (Annonaceae) Bark from Democratic Republic of Congo

<i>In Vitro</i> Anticancer Assessment of <i>Annickia chlorantha</i> (Oliv.) Setten & Maas Stem (Annonaceae) Bark from Democratic Republic of Congo