Antiplasmodial activity: The first proof of inhibition of heme crystallization by marine isonitriles

Young, Ryan M.; Adendorff, Matthew R.; Wright, Anthony D.; Davies‐Coleman, Michael T.

doi:10.1016/j.ejmech.2015.02.011

Cited by 22 publications

(20 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mode of action of these compounds was assessed using a scaled-down version of Egan's bhematin assay demonstrating that marine isonitriles inhibit b-hematin crystallisation and supported by ab initio calculations of the stability of the isonitrile complexes bound to iron in heme. 700 Gracilins A, H and L 701,702 along with tetrahydroaplysulphurin-1, 703 all isolated from Spongionella sp., were found to modulate mitochondrial function in neuroblastoma cells by regulating storage of calcium entry in a similar manner to cyclosporine A via binding to cyclophilin D. 704 Okadaic acid (OA), a potent marine cytotoxin that inhibits protein phosphatases, was originally isolated from Halichondria okadai but later identied as being produced by the dinoagellate Prorocentrum lima and actively bioaccumulated by the sponge. 705 The role and mechanism of OA accumulation by Halichondria has not yet been established.…”

Section: Spongesmentioning

confidence: 99%

Marine natural products

et al. 2017

View full text Add to dashboard Cite

Covering: 2015. Previous review: Nat. Prod. Rep., 2016, 33, 382-431This review covers the literature published in 2015 for marine natural products (MNPs), with 1220 citations (792 for the period January to December 2015) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1340 in 429 papers for 2015), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

show abstract

Section: Spongesmentioning

confidence: 99%

Marine natural products

et al. 2017

View full text Add to dashboard Cite

show abstract

“…10-Isothiocyanato-4-amorphene ( Ca3 ) displayed a weak antiplasmodial activity against Plasmodium falciparum (strains K1 and NF54, IC 50 = 5.7 µM) [ 41 ]. Furthermore, 10-isocyano-4-amorphene ( Ca2 , IC 50 = 7.2 µg/mL) and 10-isothiocyanato-4-amorphene ( Ca3 , IC 50 = 0.70 µg/mL) showed potent antifouling activity against larvae of the acorn barnacle Balanus amphitrite [ 42 ].…”

Section: Marine Isonitriles and Related Compoundsmentioning

confidence: 99%

Marine Isonitriles and Their Related Compounds

2016

View full text Add to dashboard Cite

Marine isonitriles represent the largest group of natural products carrying the remarkable isocyanide moiety. Together with marine isothiocyanates and formamides, which originate from the same biosynthetic pathways, they offer diverse biological activities and in spite of their exotic nature they may constitute potential lead structures for pharmaceutical development. Among other biological activities, several marine isonitriles show antimalarial, antitubercular, antifouling and antiplasmodial effects. In contrast to terrestrial isonitriles, which are mostly derived from α-amino acids, the vast majority of marine representatives are of terpenoid origin. An overview of all known marine isonitriles and their congeners will be given and their biological and chemical aspects will be discussed.

show abstract

“…As shown in Table 1 and Figure 1, potent (IC 50 < 2 µM) to moderate (IC 50 > 2-10 µM) antimalarial activity was reported for several marine natural products (85)(86)(87)(88)(89)(90)(91)(92)(93)(94), although the mechanism of action for these compounds remained undertermined at the time of publication. Cheng and colleagues reported potent antiplasmodial activity in the peptide actinoramide A (85) isolated from Streptomyces species "in all five (P. falciparum) lines retested" [88].…”

Section: Antiprotozoal and Antituberculosis Activitymentioning

confidence: 99%

“…Contributing to the global search for novel antimalarial drugs, and as presented in Table 1, 11 marine molecules (84-94) isolated from bacteria, molluscs, sponges, and soft corals were shown during 2014-2015 to possess antimalarial activity. Young and colleagues reported a detailed mechanistic study with the marine sesquiterpene isonitrile 7,20-diisocyanoadociane (84) originally isolated from the marine sponge Cymbastela hooperi [87], demonstrating that it inhibited β-hematin (IC 50 = 13nM), and thus interfered with the parasite's heme detoxification pathway.…”

Section: Antiprotozoal and Antituberculosis Activitymentioning

confidence: 99%

Marine Pharmacology in 2014–2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

et al. 2019

View full text Add to dashboard Cite

The systematic review of the marine pharmacology literature from 2014 to 2015 was completed in a manner consistent with the 1998–2013 reviews of this series. Research in marine pharmacology during 2014–2015, which was reported by investigators in 43 countries, described novel findings on the preclinical pharmacology of 301 marine compounds. These observations included antibacterial, antifungal, antiprotozoal, antituberculosis, antiviral, and anthelmintic pharmacological activities for 133 marine natural products, 85 marine compounds with antidiabetic, and anti-inflammatory activities, as well as those that affected the immune and nervous system, and 83 marine compounds that displayed miscellaneous mechanisms of action, and may probably contribute to novel pharmacological classes upon further research. Thus, in 2014–2015, the preclinical marine natural product pharmacology pipeline provided novel pharmacology as well as new lead compounds for the clinical marine pharmaceutical pipeline, and thus continued to contribute to ongoing global research for alternative therapeutic approaches to many disease categories.

show abstract

Antiplasmodial activity: The first proof of inhibition of heme crystallization by marine isonitriles

Cited by 22 publications

References 50 publications

Marine natural products

Marine natural products

Marine Isonitriles and Their Related Compounds

Marine Pharmacology in 2014–2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

Contact Info

Product

Resources

About