Antiplasmodial activity of Homalium letestui

Okokon, Jude E.; Ita, Basil N.; Udokpoh, Aniekan E.

doi:10.1002/ptr.1983

Cited by 16 publications

(10 citation statements)

References 4 publications

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“…They are: Cylicodiscus gabunensis (Okokon et al, 2006b), Uvaria chamae and Hippocratea africana (Okokon et al, 2006a), Enantia chlorantha and Cymbopogon giganteus (Agbaje and Onabanjo, 1991;Kimbi and Fagbenro-Beyioku, 1996), Cymbopogon citratus and Ocimum gratissimum (Tchoumbougnang et al, 2005), Cassia singueana (Adzu et al, 2003), Stachytarpheta cayennensis (Okokon et al, 2008), Striga hermonthica and Tapinanthus sessilifolius (Okpako and Ajaiyeoba, 2004), Tetrapleura tetraptera (Okokon et al, 2007b), Setaria megaphylla (Okokon et al, 2007c), Phyllanthus amarus (Dapper et al, 2007), Homalium letestui (Okokon et al, 2006c) and the plant formula 'Agbo-Iba' shown to protect mice against Plasmodium yoelii nigeriensis infection; the herbs used in this formula were decocted for 3 h and then administered to mice orally to evaluate the prophylactic and curative activities. Although the 'Agbo-Iba' formula was prophylactic and had no apparent significant side effects in mice, the formula had no curative activity against established infection (Nwabuisi, 2002).…”

Section: Scientific Authentication Of Antimalarial Activities Of Nigementioning

confidence: 99%

Potential antimalarials from Nigerian plants: A review

Adebayo

Krettli

2011

Journal of Ethnopharmacology

209

162

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Malaria, caused by parasites of the genus Plasmodium, is one of the leading infectious diseases in many tropical regions, including Nigeria, a West African country where transmission occurs all year round. Many of the inhabitants use plants as remedies against fever and other symptoms of acute malaria, as reported herein. Some of these plants have their antimalarial efficacies scientifically demonstrated and the active compounds isolated with their probable mechanisms of action studied. Medicinal plants are used to treat diseases also where the biodiversity of plants occur in parallel with endemic transmission of malaria. This review focuses on medicinal plants which are used to treat malaria in Nigeria, and on antimalarial testing of extracts and purified compounds from plants. Some show intense activity against malaria parasites in vitro and in experimentally infected mice. The search for new drugs based on plants is important due to the emergence and widespread of chloroquine-resistant and multiple drug-resistant malaria parasites, which require the development of new antimalarials. An acquaintance with antimalarial plants may be a springboard for new phytotherapies that could be affordable to treat malaria, especially among the less privileged native people living in endemic areas of the tropics, mostly at risk of this devastating disease.

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Section: Scientific Authentication Of Antimalarial Activities Of Nigementioning

confidence: 99%

Potential antimalarials from Nigerian plants: A review

Adebayo

Krettli

2011

Journal of Ethnopharmacology

209

162

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“…Homalium letestui stem has been reported to be used traditionally in the treatment of ulcer 3 . For this reason, the antiulcer activity of the stembark extract and fractions were evaluated using indomethacin, ethanol, reserpine, and histamineinduced ulcer models.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2015

IJPSR

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ABSTRACT:Homalium letestui Pellegr (Flacourtiaceae) used traditionally by the Ibibios of Southern Nigeria to treat stomach ulcer, malaria and other inflammatory diseases were evaluated for antiulcer activities of the stem extract and its fractions. The effects of ethanol stem extract of H. letestui (200-600 mg/kg) and fractions (Aqueous and dichloromethane, 400 mg/kg) on experimentally induced ulcer were studied in rats using ethanol, indomethacin, reserpine, and histamine-induced ulcer models. The extract (200-600 mg/kg) inhibited ethanol, indomethacin, reserpine, and histamine-induced ulcer models in a dose-dependent fashion. The various degrees of inhibitions were statistically significant (P<0.05, 0.01, 0.001). The effects of the extract/fraction were comparable to that of the standard drugs used in indomethacin and ethanol-induced ulcer models with the dichloromethane fraction having the highest activity. Thus, H. letestui extract demonstrated a good antiulcer activity which supports the use of this plant in traditional medicine.

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“…Alkaloids are found to inhibit the cell's central processes, an important requisite property against pathogens (Likhitwitayawuid et al, 1993). Secondary metabolites such as alkaloids have been implicated in antiplasmodial activity in many plants (Okokon et al, 2006). Alkaloids also exhibit toxicity against foreign cells in culture and are widely studied in cancer research.…”

Section: Discussionmentioning

confidence: 99%

Phytochemistry and in vitro antiplasmodial properties of aqueous and ethanol stem bark extracts of Jatropha curcas (Physic Nut)

Imam¹,

Shehu²,

Khalil³

et al. 2018

Bayero J. Pure App. Sci.

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The increasing prevalence and distribution of malaria is due to a number of factors, one of which is the emergence and spread of drug resistant parasites. Efforts are now being directed towards the discovery and development of new chemically diverse reports on the phytochemistry and in vitro antiplasmodial properties of aqueous and ethanol stem bark extract of Jatropha curcas. Maceration method of extraction was used. The two extracts were assayed at various concentrations of 10 mg/ml, 5 mg/ml, 2.5 mg/ml and 1.25 mg/ml for antiplasmodial activity against Plasmodium falciparum and were also screened for the presence of phytochemicals following standard procedure. The phytochemicals detected from both extracts were alkaloids, cardiac glycosides, anthranol glycosides, saponins, phytosterols, phenols, flavonoids, protein and amino acids and diterpenes. The result of antiplasmodial activity revealed that both the aqueous and ethanol stem bark extracts of Jatropha curcas malaria parasite. However, the aqueous extract showed statistically (P<0.05) higher activities than the ethanol extract. At extract concentration of 10mg/ml, both the ethanol and aqueous extracts produced the highest parasite clearance rate after 72 hours incubation period, with percentage elimination of 77%. From these observations, Jatropha curcas is likely to contain promising chemical compounds which can be utilized as an effective plant treatment of malaria.

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Antiplasmodial activity of Homalium letestui

Cited by 16 publications

References 4 publications

Potential antimalarials from Nigerian plants: A review

Potential antimalarials from Nigerian plants: A review

Untitled

Phytochemistry and <i>in vitro</i> antiplasmodial properties of aqueous and ethanol stem bark extracts of <i>Jatropha curcas</i> (Physic Nut)

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