Antiplasmodial activity and cytotoxicity of plants used in West African traditional medicine for the treatment of malaria

Menan, Hervé; Banzouzi, Jean-Théophile; Hocquette, Antoine; Pélissier, Yves; Blache, Yves; Koné, Moussa; Mallié, M.; Assi, Laurent Aké; Valentin, Alexis

doi:10.1016/j.jep.2005.10.027

Cited by 82 publications

(49 citation statements)

References 36 publications

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“…The decoction (54.41%) and maceration (23.07%) are the main forms. Fumigation and juice (6.41% each) (Ajibesin et al, 2008;Kaou et al, 2008;Wondimu et al, 2007;Heinrich et al, 1998) (Asase et al, 2005;Heinrich et al, 1998;Tona et al, 1999;Gbeassor et al, 1988a,b) (Ajibesin et al, 2008;Odugbemi et al, 2007;Menan et al, 2006;Zirihi et al, 2005;Asase et al, 2005;Asase and Oppong-Mensah, 2009;Azas et al, 2002 (Ajibesin et al, 2008;Gbeassor et al, 1990;Adjanohoun et al, 1986;Asase and Oppong-Mensah, 2009 ( and infusion (5.13%) are less common. The concoctions are mainly administered orally (82.05%).…”

Section: Resultsmentioning

confidence: 99%

An ethnobotanical study of antimalarial plants in Togo Maritime Region

Koudouvo

Karou

Kokou

et al. 2011

Journal of Ethnopharmacology

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Section: Resultsmentioning

confidence: 99%

An ethnobotanical study of antimalarial plants in Togo Maritime Region

Koudouvo

Karou

Kokou

et al. 2011

Journal of Ethnopharmacology

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“…precatorius pentane extract presented an IC 50 value below 20 μg/mL on FcM29-Cameroon (CQ-resistant strain) and a Nigerian CQ-sensitive strain of P. falciparum (Ménan et al 2006). Limmatvapirat et al (2004) reported recently the presence of antimalarial and antitubercular isoflavanquinone in the aerial parts of A. precatorius.…”

Section: Resultsmentioning

confidence: 99%

In vitro antimalarial activity of medicinal plant extracts against Plasmodium falciparum

Bagavan¹,

Rahuman²,

Kaushik

et al. 2010

Parasitol Res

125

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Malaria is a major global public health problem, and the alarming spread of drug resistance and limited number of effective drugs now available underline how important it is to discover new antimalarial compounds. In the present study, ten plants were extracted with ethyl acetate and methanol and tested for their antimalarial activity against chloroquine (CQ)-sensitive (3D7) and CQ-resistant (Dd2 and INDO) strains of Plasmodium falciparum in culture using the fluorescence-based SYBR Green assay. Plant extracts showed moderate to good antiparasitic effects. Promising antiplasmodial activity was found in the extracts from two plants, Phyllanthus emblica leaf 50% inhibitory concentration (IC₅₀) 3D7: 7.25 μg/mL (ethyl acetate extract), 3.125 μg/mL (methanol extract), and Syzygium aromaticum flower bud, IC₅₀ 3D7:13 μg/mL, (ethyl acetate extract) and 6.25 μg/mL (methanol extract). Moderate activity (30-75 μg/mL) was found in the ethyl acetate and methanol extracts of Abrus precatorius (seed) and Gloriosa superba (leaf); leaf ethyl acetate extracts of Annona squamosa and flower of Musa paradisiaca. The above mentioned plant extracts were also found to be active against CQ-resistant strains (Dd2 and INDO). Cytotoxicity study with P. emblica leaf and S. aromaticum flower bud, extracts showed good therapeutic indices. These results demonstrate that leaf ethyl acetate and methanol extracts of P. emblica and flower bud extract of S. aromaticum may serve as antimalarial agents even in their crude form. The isolation of compounds from P. emblica and S. aromaticum seems to be of special interest for further antimalarial studies.

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“…K. senegalensis, Opilia amentacea, and Sarcocephalus latifolius were reported in Benin (Hermans et al, 2004;Yetein et al, 2013) and other West African countries (Asase et al, 2005;Asase and Oppong-mensah, 2009;Asase et al, 2010;Koudouvo et al, 2011). Antimalarial effects have been assessed and confirmed for some most reported species such as K. senegalensis (Adebayo and Krettli, 2011;Soh and Benoit-Vical, 2007); P. crassipes (Sanon et al, 2003) and S. latifolius (Menan et al, 2006), and L. lanceolata (Audu et al, 2007;Onyeto et al, 2014). O. amentacea has not yet been screened for such analysis.…”

Section: Medicinal Uses Of Tree Speciesmentioning

confidence: 94%