Antiphospholipid Syndrome in Pediatrics

Ravelli, Angelo; Martini, Alberto

doi:10.1016/j.rdc.2007.07.001

Cited by 34 publications

(9 citation statements)

References 61 publications

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“…However, there are scarce reports concerning this disease in young patients. Ravelli and Martini analyzed 50 cases of pediatric APS and concluded that the course of the disease in children was similar to adults with chorea and jugular vein thrombosis being recognized more frequently in children, which also occurred in our case [14]. Primary APS is very rare in pediatrics.…”

Section: Discussionsupporting

confidence: 53%

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Recurrent arterial and venous thrombosis in a 16-year-old boy in the course of primary antiphospholipid syndrome despite treatment with low-molecular-weight heparin: a case report

et al. 2013

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IntroductionAntiphospholipid syndrome is a multisystem autoimmune disease characterized by arterial and/or venous thrombosis and persistent presence of antiphospholipid antibodies. It can be a primary disease or secondary when associated with other autoimmune diseases.Case presentationWe present a case of a 16-year-old Caucasian boy with a massive arterial and venous thrombosis in his lower limbs as well as in his central nervous system with clinical symptoms such as headaches and chorea. He did not present any clinical or laboratory signs of a systemic inflammatory connective tissue disease, including systemic lupus erythematosus. Based on the clinical picture and results of the diagnostic tests (positive antibodies against β2-glycoprotein and a high titre of anticardiolipin antibodies) we finally diagnosed primary antiphospholipid syndrome. During a 9-month follow up after the acute phase of the disease, he was treated with low-molecular-weight heparin. Neurological symptoms were relieved. Features of recanalization in the vessels of his lower limbs were observed. After a subsequent 6 months, because of the failure of preventive treatment – an incident of thrombosis of the vessels of his testis – treatment was modified and heparin was replaced with warfarin.ConclusionAlthough the preventive treatment with warfarin in our patient has continued for 1 year of follow up without new symptoms, further observation is needed.

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Section: Discussionsupporting

confidence: 53%

“…The most frequent common symptom was venous thrombosis of lower limb, profound veins and symptoms from the central nervous system. In four cases the children developed symptoms of systemic lupus or Hodgkin’s lymphoma [14,17]. …”

Section: Discussionmentioning

confidence: 99%

Recurrent arterial and venous thrombosis in a 16-year-old boy in the course of primary antiphospholipid syndrome despite treatment with low-molecular-weight heparin: a case report

et al. 2013

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“…Livedo reticularis These lesions present more commonly in both juvenile and adult patients who are diagnosed with anti-phospholipid syndrome [55]. It is characterized by erythematous or cyanotic discoloration of the skin with reticulated (net-like) pattern, usually on the lower extremities.…”

Section: Reviewmentioning

confidence: 99%

Mucocutaneous manifestations in juvenile-onset systemic lupus erythematosus: a review of literature

et al. 2015

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Patients diagnosed with juvenile-onset systemic lupus erythematosus (JSLE) often have skin and oral lesions as part of their presentation. These mucocutaneous lesions, as defined by the American College of Rheumatology (ACR) in 1997, include malar rash, discoid rash, photosensitivity and oral ulcers. It is therefore essential to recognize mucocutaneous lesions to accurately diagnose JSLE. The mucocutaneous lesions can be divided into those with classical histological features (LE specific) and those strongly associated with and forming part of the diagnostic spectrum, but without the classical histological changes of lupus (LE nonspecific). A malar rash is the most commonly associated LE specific dermatological presentation. This skin manifestation is an acute form and also correlates with disease activity. Subacute (polycyclic or papulosquamous lesions) and chronic (discoid lesions) forms, whilst showing classical histological changes supportive of lupus, are less commonly associated with systemic lupus and do not correlate with disease activity. The most commonly associated skin lesions without classical lupus changes are cutaneous vasculitis, oral ulcers and diffuse non-scarring alopecia. These signs frequently relate to disease activity. An understanding of cutaneous signs and symptoms of lupus in children is important to avoid delay in diagnosis. They will often improve as lupus is adequately controlled and their reappearance is often the first indicator of a disease flare.

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“…APS is the most common acquired state of hypercoagulation in both adults and children. A close association between aPL antibodies and recurrent arterial and/or venous thrombosis has been supported by several retrospective and prospective studies, and it appears that aPL antibodies have a direct role in the pathogenesis of the thrombophilic state of APS (1)(2)(3). Recurrent thrombotic events seem less frequent than in adults (4,5).…”

Section: Literature Review Pregled Literature Literature Review Preglmentioning

confidence: 91%

“…Due to the rarity of aPL antibody-related thrombosis in children, its natural history and optimal management can be determined only through large, multicentre, controlled studies (2).…”

Section: With Childhood-onset Aps Presented With Significantly More Ementioning

confidence: 99%

Paediatric antiphospholipid syndrome

Cojocaru¹,

Cojocaru²

2011

Ser J Exp Clin Res

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Antiphospholipid Syndrome in Pediatrics

Cited by 34 publications

References 61 publications

Recurrent arterial and venous thrombosis in a 16-year-old boy in the course of primary antiphospholipid syndrome despite treatment with low-molecular-weight heparin: a case report

Recurrent arterial and venous thrombosis in a 16-year-old boy in the course of primary antiphospholipid syndrome despite treatment with low-molecular-weight heparin: a case report

Mucocutaneous manifestations in juvenile-onset systemic lupus erythematosus: a review of literature

Paediatric antiphospholipid syndrome

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