Antiphospholipid antibodies levels and potential effects on in-vitro fertilization in a large cohort of infertile Syrian women

Deeb, Haya; Salam, Omar Abdul; Shaaban, Venus; Alkhatib, Adnan; Alhalabi, Nawras; Alhalabi, Marwan

doi:10.1016/j.amsu.2021.102301

Cited by 4 publications

(8 citation statements)

References 22 publications

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“…Thus, we tried to explore the situation. Results showed that, APA was positive among 20.8% of studied females which higher than reported incidence in literature (0 to 17%) (6,11,12) . Miscarriage was significantly increased among those with positive APA than females with negative APA.…”

Section: Discussioncontrasting

confidence: 50%

“…But they did not report any effects on the ICSI cycles outcome. The very low percentages of positive APA in Deeb et al (12) study may explain absent association between IVF outcome and presence of APA. The different inclusion criteria could explain the contradiction with the study of Hong et al (6) , as they included females with different autoimmune antibodies other than APA (the sole one in the current work).…”

Section: Discussionmentioning

confidence: 70%

“…APA was also associated with pregnancy associated medical diseases like hypertension and preeclampsia (13)(14)(15) . Deeb et al (12) from Syria reported a very low incidence of APA in females submitted to IVF (<1.0%), with no association between APA and any of patient demographics or IVF outcome. However, Hong et al (6) reported a prevalence rate of 14.8% positive APA among infertile females.…”

Section: Discussionmentioning

confidence: 96%

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Impact of Antiphospholipid Antibodies on Intracytoplasmic Sperm Injection Outcome

Mohamed

Khafagy

Mahmoud

et al. 2022

SJMS

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Introduction and Aim: The effect of antiphospholipid syndrome on pregnancy is extensively discussed but the debate is still ongoing. This debate increased when the association was examined after assisted reproductive techniques for infertility. The current work aimed to evaluate the influence of Antiphospholipid antibodies in patient undergo first cycle of intracytoplasmic sperm injection. Subjects and Methods: The study comprised 130 of infertile females, who were scheduled for the first ICSI cycle. Before protocol selection, basal hormonal assay was performed and included FSH, LH, E2, prolactin and AMH. Plasma concentration of anti-phospholipids (APAs) was measured. Then, females were categorized into groups according to APAs (positive and negative groups). After ICSI, the clinical pregnancy was confirmed by presence the gestational sac or sac with positive pulsation. Ongoing pregnancy was recognized if the pregnancy continued after 12 weeks of the gestation and clinical miscarriage if pregnancy terminated before 12 weeks of gestation. Results: All females were in their reproductive age (18- 40 years). Their fertility duration ranged between 1 and 7 years, and it was of primary type among 96 women. The long agonist protocol was used for 72 women and the antagonist protocol done for 58 women. The Antiphospholipid antibodies were positive among 27 females (20.8%), and there was no significant difference between APL positive and negative groups regarding pregnancy results (either chemical, clinical, incidence of abortion or ongoing pregnancy after 12 weeks) for all females. However, in women with positive clinical pregnancy, the rate of abortion was significantly increased in patients with APL- positive than negative females (66.7% vs 26.7%). Conclusion: The presence of APA was associated with higher significant abortion rate after the first cycle of ICSI. Thus, screening for APA in women with infertility scheduled for assisted reproduction is recommended.

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Section: Discussioncontrasting

confidence: 50%

Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 96%

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Impact of Antiphospholipid Antibodies on Intracytoplasmic Sperm Injection Outcome

Mohamed

Khafagy

Mahmoud

et al. 2022

SJMS

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“…Fourth, VDD is associated with a rise in APA in patients with RSA 34 . And RSA is one of the important complications of antiphospholipid syndrome (APS) which caused by cytokine overreaction such as APA and ANA 40,41 . Therefore, we speculate that VDD can cause RSA occurrence by increasing the level of autoimmunity.…”

Section: Discussionmentioning

confidence: 92%

“…34 And RSA is one of the important complications of antiphospholipid syndrome (APS) which caused by cytokine overreaction such as APA and ANA. 40,41 Therefore, we speculate that VDD can cause RSA occurrence by increasing the level of autoimmunity. Fifth, the study found that VDD is correlated with the development of autoimmune thyroid disease (AITD).…”

Section: Discussionmentioning

confidence: 95%

Association between serum vitamin D level during pregnancy and recurrent spontaneous abortion: A systematic review and meta‐analysis

Chen

Wang

Zhang

et al. 2022

American J Rep Immunol

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Problem Previous studies had shown that there might be an association between serum vitamin D concentrations and the occurrence of recurrent spontaneous abortion (RSA). However, the conclusions remained controversial. The objective of this study was to systematically review the evidence for an epidemiological association between vitamin D and RSA. Method of study The literature search was performed in the following databases: PubMed, Web of Science, Embase and Chinese databases. The I2 statistic was used to evaluate heterogeneity. Effect sizes were calculated using fixed or random effects models, including standardized mean difference (SMD), odds ratios (OR) and their 95% confidence intervals (95% CI). Then, we performed subgroup analysis, sensitivity analysis and publication bias analysis. Results Fourteen studies from five countries were included. Based on the results, patients with RSA had lower vitamin D levels than controls (SMD = ‐1.48, 95% CI: ‐2.01, ‐.94, P < .001), and pregnant women with vitamin D deficiency (VDD) had a higher risk of developing RSA (OR = 4.02, 95% CI: 2.23, 7.25, P < .001). There was remarkable heterogeneity between studies (I2SMD = 97.3%, P < .001; I2OR = 82.2%, P < .001). The results of the subgroup analysis suggested that heterogeneity may be caused by the assay method, age and region. Sensitivity analysis showed the analysis results were robust. Conclusion Patients with RSA had lower serum vitamin D levels than normal pregnant women, and pregnant women with VDD might be at higher risk for RSA.

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The prevalence of antiphospholipid antibodies and effects on the outcomes of in vitro fertilization

Halki,

Khalayli,

Haidar

et al. 2024

International Journal of Surgery: Global Health

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Introduction: The problem of infertility is common worldwide. IVF remains the most widely used technique of assisted reproductive technology. Embryo implantation failure is a common cause of unexplained infertility and recurrent miscarriages, thus the relationship between antiphospholipid antibodies and embryo implantation failure after IVF and embryo transfer is an important problem in fertility medicine that must be studied. Patients and methods: A retrospective and prospective (bidirectional) cohort study were conducted at the Laboratory Department of the Faculty of Medicine, and Hospital from June 2017 to June 2021. The sample size was 1000 participants, 900 of them were retrospective (2017–2020), and 100 were prospective (2020–2021). Data was collected, including patients’ demographics, type and duration of fertility, and antiphospholipid antibody values. Inclusion criteria-Women <40 years old, undergoing IVF, and in the retrospective study, patients who undergo IVF and who have antibody data, positivity of phospholipids, and/or anticardiolipin, and/or B2 glycoprotein I, and the presence of the gestational sac on ultrasound as a criterion for pregnancy. We performed a PTT LA for the control group in a cohort study (20 healthy women), then a PTT LA test, and the blending test were performed, and the values were considered positive if the correction was not made. The PTT LA test is a screening test. Results: The average age of the women was 31.91, the success rate of assisted fertilization in inducing pregnancy in the last trial was 52.8%, the prevalence was 4.4% of anticardiolipin IgG, 2.6% of anticardiolipin IgM, and 4% of Lupus anticoagulant. No relation was found between the antiphospholipid value and the age of the women, the number of times the experiment was conducted, the rate of success and failure, the type of infertility, and the number of oocytes induction, while the duration of sterility was affected by positive values of IgG and lupus coagulant antibodies. Conclusion: There is no need for a routine antiphospholipid assay for female candidates for IVF, and when it is confirmed, treatment is required by Anticoagulants.

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Antiphospholipid antibodies levels and potential effects on in-vitro fertilization in a large cohort of infertile Syrian women

Cited by 4 publications

References 22 publications

Impact of Antiphospholipid Antibodies on Intracytoplasmic Sperm Injection Outcome

Impact of Antiphospholipid Antibodies on Intracytoplasmic Sperm Injection Outcome

Association between serum vitamin D level during pregnancy and recurrent spontaneous abortion: A systematic review and meta‐analysis

The prevalence of antiphospholipid antibodies and effects on the outcomes of in vitro fertilization

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