Antiphospholipid Antibodies in Vascular Surgery Patients A Cross-Sectional Study

Taylor, Lloyd M.; Chitwood, Richard W.; Dalman, Ronald L.; Sexton, Gary; Goodnight, Scott H.; Porter, John M.

doi:10.1097/00000658-199410000-00012

Cited by 53 publications

(25 citation statements)

References 18 publications

(3 reference statements)

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“…22 Among patients with PAD, depressive symptoms were found to be associated with poorer lower extremity functioning. 101 Other possible risk factors for which some supporting data exist include antiphospholipid antibodies, 102,103 hypothyroidism, 104 sedentary lifestyle, 105 and exposure to toxic heavy metals. 106 A PAD global burden in 2010 project compiled the data on PAD epidemiology and associated risk factors.…”

Section: Other Risk Factorsmentioning

confidence: 99%

Epidemiology of Peripheral Artery Disease

Criqui

Aboyans

2015

Circulation Research

1,269

961

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New data on the epidemiology of peripheral artery disease (PAD) are available, and they should be integrated with previous data. We provide an updated, integrated overview of the epidemiology of PAD, a focused literature review was conducted on the epidemiology of PAD. The PAD results were grouped into symptoms, diagnosis, prevalence, and incidence both in the United States and globally, risk factors, progression, coprevalence with other atherosclerotic disease, and association with incident cardiovascular morbidity and mortality. The most common symptom of PAD is intermittent claudication, but noninvasive measures, such as the anklebrachial index, show that asymptomatic PAD is several times more common in the population than intermittent claudication. PAD prevalence and incidence are both sharply age-related, rising >10% among patients in their 60s and 70s. With aging of the global population, it seems likely that PAD will be increasingly common in the future. Prevalence seems to be higher among men than women for more severe or symptomatic disease. The major risk factors for PAD are similar to those for coronary and cerebrovascular disease, with some differences in the relative importance of factors. Smoking is a particularly strong risk factor for PAD, as is diabetes mellitus, and several newer risk markers have shown independent associations with PAD. PAD is strongly associated with concomitant coronary and cerebrovascular diseases. After adjustment for known cardiovascular disease risk factors, PAD is associated with an increased risk of incident coronary and cerebrovascular disease morbidity and mortality.

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Section: Other Risk Factorsmentioning

confidence: 99%

Epidemiology of Peripheral Artery Disease

Criqui

Aboyans

2015

Circulation Research

1,269

961

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“…However, in the HD group, 21 of 54 patients had IgG aCL levels >10 ml/IU (38.89%), a value higher than 26% prevalence of aCL in a general population of vascular surgery patients [21](fig. 2).…”

Section: Resultsmentioning

confidence: 99%

Association of Anticardiolipin Antibodies with Vascular Access Occlusion in Hemodialysis Patients: Cause or Effect?

2000

Nephron

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Background: Uremic patients on hemodialysis (HD) often display occlusive disorders despite their uremic thromboasthenia. The role of anticardiolipin antibodies (aCL) and the recently identified anti-β₂-glycoprotein I antibodies (aβGPI) in these phenomena is unknown. Methods: The prevalence of IgG and IgM aCL and aβGPI was documented in 54 HD patients and 19 nondialyzed patients with chronic renal failure (CRF). The HD patients were further divided into arteriovenous (AV) access occluders and nonoccluders. Results: HD patients had a higher mean IgG aCL level than CRF patients (14.68 ± 3 vs. 2.96 ± 1 IU/ml, respectively, p < 0.0007). IgM aCL did not differ significantly. AV access occluders had a higher mean IgG and IgM aCL levels than nonoccluders (24.47 and 8.39 IU/ml in occluders vs. 8.45 and 3.59 IU/ml in nonoccluders, p < 0.0226 and p < 0.05, respectively). IgM and IgG aβGPI antibody levels were below the cutoff point and did not differ significantly between the various groups. Cardiovascular episodes were not correlated with the titer of aCL or aβGPI. Conclusion: These results indicate that HD, especially in patients with recurrent access occlusion episodes, is associated with elevated levels of IgG aCL, and that IgG aCL level may predict the occlusive status of HD patients.

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“…The propensity of patients with peripheral vascular disease for DVT may reflect preoperative limb ischemia, prolonged immobility, elevated plasma homocysteine levels, and associated hypercoagulable states. [6][7][8]30,31 Although our study was not intended to be a screening of patients with symptomatic peripheral vascular disease, three (4.1%) of 74 patients screened before undergoing lower extremity revascularization had incidental lower extremity DVT. Although there may be a higher prevalence of DVT in patients with peripheral vascular disease compared to the general population, according to our series, the risk does not seem to be increased in patients before or after lower extremity revascularization, with a 4.1% and 2.8% incidence of DVT, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…[6][7][8] Because the incidence of DVT in patients undergoing lower extremity revascularization is not well documented, recommendations for routine prophylaxis cannot be established. The purpose of this study was to prospectively evaluate the risk of DVT in patients undergoing infrainguinal revascularization.…”

mentioning

confidence: 99%