Antiphospholipid antibodies in relation to sterility/infertility

Antibodies and autoimmune diseases in relation to reproductive failures

“…Hungarian and international literature (92,93,94,95,96), and successful conception of 155 children occurred during our treatments. As far as we know, we published on this topic as first in Hungary.…”

“…Summing up, it can be stated that the previously undetected APS may be an important etiologic factor underlying sterility/infertility; furthermore an appropriate therapy can terminate the adverse effects of aPLs that cause morbidities of pregnancy (92,93,94).…”

“…Our results demonstrate that levothyroxine substitution should start already prior to conception in patients with latent or overt hypothyroidism and it should be continued, with close monitoring of TSH levels during pregnancy. As sterility/infertility may also be caused by autoimmune thyroiditis in a euthyroid patient, regular checking of TSH in TPO-positive women of reproductive age should be underlined; in these cases the upper limit of TSH is 2.5 U/L (93,94).…”

Anti‐mullerian hormone levels decline with the presence of antiphospholipid antibodies

“…When present at abnormally high levels, they, however, have been associated with autoimmune diseases 15 and have been found in HIV infections and other viral diseases, 16 allergies, 17 but also in association with cancers, 18 allogeneic organ transplantation, 19 the obstetrical complication preeclampsia, 20 pathophysiological, likely similar to organ transplant, complications, 21 and in female infertility. 22 While specifically associated with increased arterial as well as venous thrombotic risks, 23 they, in above noted conditions, because of their non-specific nature and association with so many divergent conditions, can be viewed as non-specific evidence of inflammation and of a polyclonal B cell activation, routinely observed in activated immune system associated with autoimmune conditions. 24 Here, observed association between decreasing levels of AMH in infertile women and the presence of APAs can, therefore, be viewed as further evidence that at least some women with LFOR experience a degree of inflammatory response, likely directed at their ovaries.…”

Antiphospholipid Antibody Syndrome and Infertility

“…The antimullerian hormone is produced by growing follicles from granulosa cells that harbor the oocytes until their maturation, and its levels remain stable throughout the whole menstrual cycle. 9,10 The pathogenesis of obstetric morbidity on APS is not yet fully understood; however, it may happen due to the negative effect that the antiphospholipid antibodies exert on the placental function, decreasing the trophoblastic viability and its invasiveness. Furthermore, recent evidence suggest that the inflammatory factor can also justify the poor obstetrics prognosis.…”