“…Our results illustrated some aspects of these complex changes in sepsis, and we hypothesized that aPL might have the potential for predicting future organ failure and could be used as an indicator to predict in-hospital mortality in intensive care unit (ICU). Our findings are supported by previous studies which reported the occurrence of aPL as pathogenic in different diseases such as in cancer [ 23 , 24 ], acute respiratory distress syndrome (ARDS) [ 25 ], human immunodeficiency virus (HIV) [ 26 ], acute kidney injury (AKI) [ 27 ], and more recently in COVID-19 [ 11 , 28 – 30 ]. In our study, we measured aCL IgM, IgG, IgA and aPS IgM, IgG, and IgA autoantibodies in septic patients, without a clinical history of auto-immune disease, at different time points during their hospitalization in ICU.…”