Antipeptide Antibodies to Adenovirus E1b Protein Indicate Enhanced Risk of Celiac Disease and Dermatitis herpetiformis

Abstract

The relationship between adenovirus type 12 (Ad12), celiac disease (CD) and dermatitis herpetiformis (DH) was evaluated by enzyme-linked immunosorbent assay (ELISA). Diagnostic phase serum samples from 44 children with CD, 16 children with DH and 60 matched controls were studied for serum antibodies to synthetic peptides derived from an early E1b protein of Ad12 and A gliadin. Both the patient groups had significantly (p < 0.01) higher IgG antibody levels to the Ad12 E1b peptide than the controls. The difference was especially pronounced for girls (p < 0.005). Antipeptide IgG antibodies to Ad12 E1b and A gliadin posed a synergistic increase in the CD and DH risk suggesting that infection with Ad12 is associated with CD and DH.

Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: the TEDDY study

“…According to our results, cumulative adenoviral infections were associated with reduced risk for CDA after gluten introduction up to 1 year of age suggesting a putatively protective role. Our finding thus contradicts previous results that have pointed to either an inductive role11 32 33 or no role at all 12 34 35. Since none of the previous studies focused on the age window before 1 year of age, our finding of a possible protective effect of adenoviral infections warrants further research.…”

Infections May Have a Protective Role in the Etiopathogenesis of Celiac Disease

“…14 A brief review of the medical literature reveals multiple infectious agents that are believed to contribute to the development of CD in susceptible patients. Among the best studied are adenovirus type 12 [15][16][17][18][19][20][21] and hepatitis C virus (HCV). [22][23][24][25] Other infectious agents, described mainly in case reports, include Campylobacter jejuni, Giardia lamblia, rotavirus, and enterovirus.…”

Antibody response to adenovirus Elb‐derived synthetic peptides and serum levels of p53 in patients with gastrointestinal and other malignant lymphomas

“…Although the enteropathy associated lymphomas (EATCL) usually are of T-cell origin [Chott et al, 19921 the mucosal associated lymphoid tissue (MALT) gives rise to a wide variety of nonHodgkin lymphomas [NHLs; Wolf et al, 19901. Since adenoviruses may persist in the lymphoid tissue and in the gut [Neumann et al, 1987;Mahon et al, 19911 and there is a n association between Ad12 and CD [Kagnoff et al, 1984[Kagnoff et al, ,1987Lahdeaho et al, 1993a,bl, seroepidemiological studies on the role of adenovirus in malignant lymphomas are warranted.…”