Antipellagric Properties of Quinolinic Acid

Vilter, Richard W.; Spies, Tom D.

doi:10.1016/s0140-6736(00)62204-3

Cited by 9 publications

(11 citation statements)

References 4 publications

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“…Woolley, Strong, Madden, and Elvehjem reported it to be inactive in the dog, but Vilter and Spies (145) concluded that it cured pellagra in humans. Woolley, Strong, Madden, and Elvehjem reported it to be inactive in the dog, but Vilter and Spies (145) concluded that it cured pellagra in humans.…”

Section: Liebig (89) and Othersmentioning

confidence: 99%

The Structure and Estimation of Natural Products Functionally Related to Nicotinic Acid.

Elvehjem¹,

Teply²

1943

Chem. Rev.

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Section: Liebig (89) and Othersmentioning

confidence: 99%

The Structure and Estimation of Natural Products Functionally Related to Nicotinic Acid.

Elvehjem¹,

Teply²

1943

Chem. Rev.

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“…This problem has been repeatedly studied for over 40 years, and yet no generally acceptable conclusions have been reached. The subject is reviewed by Vilter, Woolford and Spies (1946), Cartwright (1947), Vilter (1947), Brown (1951, 1955), Lind (1960) and Cox, Meynell, Cooke and Gaddie (1962).…”

Section: Discussionmentioning

confidence: 99%

“…The first detailed account of an ‘anaemia of scurvy’ was given by Mettier, Minot and Townsend (1930), but these authors also pointed out that anaemia may be absent even when scurvy is severe. Several workers have since shown that vitamin C deficiency without clinical scurvy is not associated with an increased incidence of anaemia (Croft and Snorf 1939; Lui, Chu, Yu, Hsu and Cheng 1941; Lozner 1941; Schulze and Morgan 1946; Vilter et al 1946). Nevertheless, cases of scurvy with anaemia which respond to the administration of vitamin C alone, with no other haemopoietic factor, continue to be described (Parsons and Hawksley 1933; Parsons and Smallwood 1935; Dunlop and Scarborough 1935; McFarlane 1936; Nisenson and Cohen 1937; Jennings and Glazebrook 1938; Parsons 1938; Young 1938; Kenney and Rapoport 1939; Braganca and Saha 1943; Vilter et al 1946; C. Vilter 1947; R. Vilter 1947; Brown 1951; Brontë‐Stewart 1953; Brown 1955; Neilson 1960; Will and Murdoch 1960; Cox et al 1962 and the present authors).…”

Section: Discussionmentioning

confidence: 99%

Scurvy, Megaloblastic Anaemia and Osteoporosis

Hyams

Ross

1963

Int J Clinical Practice

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Clinical scurvy in the adult is uncommon in this country so that the opportunities for observing its complications are infrequent. One of these, megaloblastic anaemia, is well recognized, but osteoporosis of a degree sufficient to produce crush fractures of vertebrae is rare. This paper records observations on a patient with scurvy complicated by megaloblastic anaemia and osteoporosis who was treated with vitamin C as the sole medication. Case HistoryMrs. D. K., a housewife aged 54, was admitted to University College Hospital (St. Pancras Hospital) on 30th June, 1959. She had been well until a year before admission. Low back pain then developed and later she experienced cramps in the calves and difficulty in walking. Her ankles then became swollen. Extensive ecchymoses appeared on the lower limbs two weeks before admission. The patient thought that she had lost. 3. 4 inches in height in the past year, during which she had attended another hospital for low back pain. She had been provided with a plaster cast, and later a spinal brace, but these appliances had made her back stiffer and she had refused further treatment. She had also consulted an osteopath.The day before admission to hospital she had developed very se\'ere lumbar pain, • like a knife in my back'; her husband volunteered the information that the pain had been so severe that she had threatened to put her head in a gas oven.The patient was menopausal, menstruation having ceased at the age of 50. In her past history she had diphtheria at the age of 18, but nothing else of note apart from the exanthemata of childhood.The patient's husband's place of work was 40 miles away from home. He left at a very early hour in the morning and returned home late at night. The patient felt lonely and neglected and did not trouble to prepare cooked meals for herself. A dietary history showed that the patient's diet had been very deficient of vitamin C for about 3 years, although her intake of calcium and vitamin D had been reasonable (Table I). She had lived almost entirely on sandwiches. Vege• * Now senior medical registrar, _.,,_ddenbrookl''s Hospital, Cambridge TABLE I Calculate,d daily die1ary inlake ot patient Calories 1540 Carbohydrate (g.) 212 Fat (g.) 59 Protein (g.) 40 Calcium (mg.) 566 Iron (mg.) 8. Vilamin C (mg.) 3 Vitamin D (1.U.) 151The fundamental treatment for hay fever, asthma and other allergies is

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“…If this view is true, substances other than nicotinamide having a similar protective effect may have similar therapeutic effects. It may be noted in this connexion that Vilter & Spies [1939] have shown that quinolinic acid will cure pellagra and that Woolley et at. [1938] find that a variety of nicotinic acid derivatives will cure canine black tongue.…”

Section: -mentioning

confidence: 99%

“…[1938] find that a variety of nicotinic acid derivatives will cure canine black tongue. Moreover, as a result of the administration of quinolinic acid, there has been found [Vilter & Spies, 1939] an increase in concentration of cozymase in the blood. It is clear that further investigation is required of the types of molecules which will inhibit cozymase breakdown by mammalian tissues.…”

Section: -mentioning

confidence: 99%

Nicotinamide, Cozymase and Tissue Metabolism

Mann¹,

Quastel²

1941

Nature

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DURING the course of experiments on the respiratory activities of intact, minced and ground mammalian tissues we have found that there exists in brain and in liver a very active mechanism which accomplishes the breakdown of cozymase u'nder both aerobic and anaerobic conditions. We have also found that this mechanism can be inhibited in a specific manner by nicotinamide. A preliminary note incorporating these results has already been published [Mann & Quastel, 1941]. The following communication is concerned with a description in detail of these atid further results, together with observations on the effects of nicotinamide on the inhibitory activity of cobra venom in respiratory systems. TECHNIQUE Measurements of respiratory activity The Warburg apparatus has been used for the measurement of rates of 02 uptake, or of CO2 output when using the anaerobic technique of Quastel & Wheatley [1938]. The volume of'fluid in the respiratory vessel.was always maintained at 3 ml. and experiments were at 370 for periods usually not longer than 1 hr. Preparation of biological material Ground tissues. In our first experiments with ground brain, we used rat brain tissue (1 part brain to 10 parts 0-9 % NaCl) which had been finely ground in the wet-crushing mill of Booth & Green. This gave an excellent preparation having a high activity in breaking down cozymase. Subsequently, however, it was found unnecessary to use the wet-crushing mill, since a very active preparation could be made simply by grinding the tissue with sand in the presence of 0'9 % NaCl. The finely ground tissue was squeezed through muslin and the extract diluted with 09 % NaCl so that 10 ml. of the fluid contained 1 'g. of the

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Antipellagric Properties of Quinolinic Acid

Cited by 9 publications

References 4 publications

The Structure and Estimation of Natural Products Functionally Related to Nicotinic Acid.

The Structure and Estimation of Natural Products Functionally Related to Nicotinic Acid.

Scurvy, Megaloblastic Anaemia and Osteoporosis

Nicotinamide, Cozymase and Tissue Metabolism

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