Antiparasitic effect of the Psidium guajava L. (guava) and Psidium brownianum MART. EX DC. (araçá-de-veado) extracts

Machado, Antônio Júdson Targino; Santos, Antônia Thassya Lucas dos; Martins, Gioconda M.A.B.; Cruz, Rafael Pereira da; Costa, Maria do Socorro; Campina, Fábia F.; Freitas, Maria Audilene de; Bezerra, Camila Fonseca; Leal, Antônio Linkoln Alves Borges; Carneiro, Joara Nályda Pereira; Coronel, Cathia; Rolón, Míriam; Gómez, Celeste Vega; Coutinho, Henrique Douglas Melo; Morais-Braga, Maria Flaviana Bezerra

doi:10.1016/j.fct.2018.03.018

Cited by 19 publications

(5 citation statements)

References 26 publications

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“…Only the hydroethanolic extracts at 1000 µg/mL of P. brownianum had antiparasitic effectiveness on L. braziliensis (58.46%) and L. infantum (37.16%). 28 In this study, it was confirmed that the ethanolic extract of P. guajava did not have a significant efficiency on cell death, which was 22.58%. Additionally, cytotoxicity of the ethanolic extract of P. guajava leaves was tested and its low toxicity on fibroblasts was demonstrated, indicating that only high concentrations of the extracts would be the most effective (1000 µg/mL) and that the ethanolic extract was more effective than its metabolic fractions, so the metabolites could synergize in their parasitic activity against the promastigotes of L. brazilensis and L. infantum.…”

Section: Discussionmentioning

confidence: 51%

Antiparasitic effect of Psidium guajava on promastigotes and axenic amastigotes of Leishmania

Rojas‐Jaimes¹,

Mesía-Guevara²,

Rojas-Puell³

et al. 2023

Pharmacogn J.

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Background: Leishmaniasis is a stigmatic and mutilating disease due to pathogenic species of the genus Leishmania which, depending on the species and the individual's immune status, may vary clinically from a cutaneous, mucosal, and visceral form, and for which there is no suitable treatment without significant side effects. Objectives: To measure the effect of ethanolic and aqueous extracts of Psidium guajava against axenic promastigotes and amastigotes of Leishmania spp. Methods: The method of [3-(3,4 -dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] was used to study the antiparasitic effects of ethanolic (100mg/mL) and aqueous (100mg/mL) extracts of Psidium guajava on axenic amastigotes cultures (8.1 x10 3 parasite/mL) and promastigotes (12 x 10 4 parasite/mL) obtained from a patient with cutaneous leishmaniasis, and the percentage of parasite death was evaluated in comparison with Glucantime (300mg/mL) and untreated parasite cultures. Results: Regarding parasite death in promastigotes, the ethanolic and aqueous extracts had a percentage of 22.58% and -45.16%, respectively, with no significant difference between treatments (N=3) (p= 0.058). In contrast, the ethanolic and aqueous extracts had an antiparasitic percentage of 91.67% and -70.83%, respectively, with a significant difference between treatments (N=3) (p<0.05). Conclusions: Our study showed high and significant effectiveness in parasite death (91.67%) of Leishmania axenic amastigotes of the ethanolic extract (100mg/mL) of Psidium guajava, being this result promising and the basis for in vivo studies, using the ethanolic extraction of P. guajava.

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Section: Discussionmentioning

confidence: 51%

Antiparasitic effect of Psidium guajava on promastigotes and axenic amastigotes of Leishmania

Rojas‐Jaimes¹,

Mesía-Guevara²,

Rojas-Puell³

et al. 2023

Pharmacogn J.

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“…Essential oil obtained from leaves of P. guajava was evaluated for its antiproliferative activity against human gliobastoma (M059J), human cervical adenocarcinoma (HeLa), breast adenocarcinoma (MCF-7) and normal human GM07492A cell lines, whereas lung fibroblasts cell line was used as control. The reported results showed that the oil exhibited significant IC 50 values for M059J and MCF-7 compared to normal line as presented in Table 8 [ 61 ].…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

“…The essential oil has shown moderate activity for various genus of Streptococcus . The activity was described in terms of MIC values S. sobrinus has MIC value of 100 µg/mL, S. mitis has MIC value of 200 µg/mL, S. mutans has MIC value of 200 µg/mL), S. salivarius has MIC value of 200 µg/mL and sanguinis has MIC value of 400 µg/mL [ 61 ]. The crude extracts obtained from P. guajava leaves were evaluated for antimicrobial activities by Priscilla Alexander et al 2019 have evaluated the antimicrobial activities.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Psidium guajava L. An Incalculable but Underexplored Food Crop: Its Phytochemistry, Ethnopharmacology, and Industrial Applications

et al. 2022

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Psidium guajava L. (guava) is a small tree known for its fruit flavor that is cultivated almost around the globe in tropical areas. Its fruit is amazingly rich in antioxidants, vitamin C, potassium, and dietary fiber. In different parts of the world, this plant holds a special place with respect to fruit and nutritional items. Pharmacological research has shown that this plant has more potential than just a fruit source; it also has beneficial effects against a variety of chronic diseases due to its rich nutritional and phytochemical profile. The primary goal of this document is to provide an updated overview of Psidium guajava L. and its bioactive secondary metabolites, as well as their availability for further study, with a focus on the health benefits and potential industrial applications. There have been several studies conducted on Psidium guajava L. in relation to its use in the pharmaceutical industry. However, its clinical efficacy and applications are still debatable. Therefore, in this review a detailed study with respect to phytochemistry of the plant through modern instruments such as GC and LC-MS has been discussed. The biological activities of secondary metabolites isolated from this plant have been extensively discussed. In order to perform long-term clinical trials to learn more about their effectiveness as drugs and applications for various health benefits, a structure activity relationship has been established. Based on the literature, it is concluded that this plant has a wide variety of biopharmaceutical applications. As a whole, this article calls for long-term clinical trials to obtain a greater understanding of how it can be used to treat different diseases.

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“…As for American trypanosomiasis, it is known in Brazil as "Chagas disease", and it is an infection caused by flagellated protozoa of the species Trypanosoma cruzi being transmitted mainly by female triatomines belonging to the genus Triatoma, Panstrongyluse and Rhodnius during blood meal. In addition to this form of transmission, strains are transmitted through blood, vertical, oral and accidental routes (Coura, 2015;Machado et al, 2018). It is estimated that around 8 million people are chronically infected by the protozoan with an annual rate of 12 thousand deaths, and in Brazil the highest prevalence occurs in the Research, Society and Development, v. 9, n. 9, e889997967, 2020 (CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org/10.33448/rsd-v9i9.7967…”

Section: Introductionmentioning

confidence: 99%

“…The second drug, Benzonidazole, has some restrictions in the treatment of disease and has low efficacy during the chronic phase of the disease and high rates of treatment interruption due to subsequent side effects. Such a drug acts by inhibiting the synthesis of proteins and RNA in extracellular and intracellular forms present in the parasitized host (Cruz et al, 2016;Ferreira, 1990;Machado et al, 2018;Pedra et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Antiparasitary potential and cytotoxic effect of Spondias tuberosa Arruda (Anacardiaceae)

Gómez¹,

Rolón²,

Coronel³

et al. 2020

RSD

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The objective of this work was to evaluate the antiparasitic potential and cytotoxic effect of extracts by the leaves and roots of S. tuberosa. The results show that the extracts of S. tuberosa have low antipromastigote activity against strains of L. braziliensis, since there was no action at concentrations ≤ 500 µg/mL. While for L. infantum there was a significant action of the hydroalcoholic extract of the roots against promastigote forms, since there was 29.33 ± 1.94% of mortality for the treatment of 1000 µg/mL. The same extract showed antiepimastigote action against T. cruzi at a concentration ≥ 1000 µg/mL. Despite the low antiparasitic activities, it is possible to observe that the extracts of S. tuberosa have no cytotoxic action, except the hydroalcoholic extract of the roots. In this extract there was a total of 27.85 ± 2.41% of cytotoxicity against fibroblastic cells, in the highest concentration evaluated (1000 µg/mL).

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Antiparasitic effect of the Psidium guajava L. (guava) and Psidium brownianum MART. EX DC. (araçá-de-veado) extracts

Cited by 19 publications

References 26 publications

Antiparasitic effect of Psidium guajava on promastigotes and axenic amastigotes of Leishmania

Antiparasitic effect of Psidium guajava on promastigotes and axenic amastigotes of Leishmania

Psidium guajava L. An Incalculable but Underexplored Food Crop: Its Phytochemistry, Ethnopharmacology, and Industrial Applications

Antiparasitary potential and cytotoxic effect of Spondias tuberosa Arruda (Anacardiaceae)

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