Antiparasitic agents

Martins, Maurício Laterça; Jerônimo, Gabriela Tomas; Brum, Aline; Tancredo, Karen Roberta; Bertaglia, Elisabeth A.; Furtado, William Eduardo; Lehmann, Nicollas Breda; Azevedo, Patricia Floriano Oreano de; Mouriño, José Luiz Pedreira

doi:10.1016/b978-0-12-821339-1.00002-7

Cited by 5 publications

(2 citation statements)

References 214 publications

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“…Previous studies have shown that this type of basil has anaesthetic, anti-stress, anti-inflammatory, anthelminthic, antidiarrhoeal ( Offiah and Chikwendu, 1999 ), antipyretic, anti-mutagenic, anti-ulcerative, gastroprotective, hepatoprotective, sedative, and fungicidal properties, validating its widespread medical use ( Priyanka et al., 2018 ; Martins et al., 2021 ). O .…”

Section: Botanical Description Distribution and Taxonomymentioning

confidence: 88%

A review on the traditional uses, phytochemistry, and pharmacological activities of clove basil (Ocimum gratissimum L.)

Ugbogu

Emmanuel

Agi

et al. 2021

Heliyon

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In traditional medicine, Ocimum gratissimum (clove basil) is used in the treatment of various diseases such as diabetes, cancer, inflammation, anaemia, diarrhoea, pains, and fungal and bacterial infections. The present study reviewed the phytochemicals, essential oils, and pharmacological activities of O. gratissimum . The bioactive compounds extracted from O. gratissimum include phytochemicals (oleanolic acid, caffeic acid, ellagic acid, epicatechin, sinapic acid, rosmarinic acid, chlorogenic acid, luteolin, apigenin, nepetoidin, xanthomicrol, nevadensin, salvigenin, gallic acid, catechin, quercetin, rutin, and kaempfero) and essential oils (camphene, β-caryophyllene, α- and β-pinene, α-humulene, sabinene, β-myrcene, limonene, 1,8-cineole, trans-β-ocimene, linalool, α- and δ-terpineol, eugenol, α-copaene, β-elemene, p-cymene, thymol, and carvacrol). Various in vivo and in vitro studies have shown that O. gratissimum and its bioactive constituents possess pharmacological properties such as antioxidant, anti-inflammatory, anticancer, hepatoprotective, antidiabetic, antihypertensive, antidiarrhoeal, and antimicrobial properties. This review demonstrated that O. gratissimum has a strong preventive and therapeutic effect against several diseases. The effectiveness of O. gratissimum to ameliorate various diseases may be attributed to its antimicrobial and antioxidant properties as well as its capacity to improve the antioxidant systems. However, despite the widespread pharmacological activities of O. gratissimum , further experiments in human clinical trial studies are needed to establish effective and safe doses for the treatment of various diseases.

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Section: Botanical Description Distribution and Taxonomymentioning

confidence: 88%

A review on the traditional uses, phytochemistry, and pharmacological activities of clove basil (Ocimum gratissimum L.)

Ugbogu

Emmanuel

Agi

et al. 2021

Heliyon

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“…It is a perennial climbing plant whose main commercial output is its fruit, while traditional medicine also uses its roots, seeds, stem bark, and leaves. [1] According to [2] It is a West African spice that goes by the names Ashanti pepper, Iyere in Yoruba, and Uziza in Igbo. Other frequent names are false cubeb, Guinea pepper, and Benin pepper [2].…”

Section: Introductionmentioning

confidence: 99%

The effect of methanol extract of Piper guineense on paracetamol induced toxicity

Maryann Ugochinyere Udebunu,

Aloysius Chinedu Ene,

Cosmas Oyedikachi Ujowundu

et al. 2023

World J. Adv. Res. Rev.

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Methanol extract of Piper guineense seed was administered to Swiss albino rats to asses the effect on paracetamol induced toxicity. Thirty-six albino rats were divided into six groups of six animals per group. Four groups were administered in increasing doses of the extract 50, 100, 150, 200 mg/body weight where as the fifth group was administered 500kg/kg of paracetamol as the positive control, while the sixth group was used as normal control. The duration of the experiment was two weeks. This study revealed that the paracetamol increased the biochemical parameters. This was attenuated by the co-administration of Piper guineense extract by oral gavage (50, 100, 150, 200mg/kg b.w). The biochemical parameter studied showed consistent changes. The chronic administration of paracetamol 500 kg/b,w showed an elevation in ALT, AST, MDA, total protein, total bilirublin, total protein, globulin And a depletion of SOD(superoxide dismutase), catalase, ALP, Albumin and Albumin/ globulin GSH (reduced glutathione),levels. Administration of methanol extract of Piper guineense attenuated the levels ALT, AST, GSH( reduced glutathione), SOD(superoxide dismutase),total protein, total bilirublin, total protein, globulin levels. Piper guineense ameliorated MDA, catalase, urea, ALP, Albumin and Albumin/ globulin levels restoring it significantly. The histopathology results of the effect methanol extract of Piper guineense on paracetamol induced toxicity. It Concurs with the result of the biochemical parameters. From this study it can be concluded that methanol extract of Piper guineense possess some potent antioxidants which can ameliorate damage associated with chronic exposure to paracetamol exposure in rat models.

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Plastics, Food Security, and Sustainable Urbanization

Olatunji

2024

Re-Envisioning Plastics Role in the Global Society

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Antiparasitic agents

Cited by 5 publications

References 214 publications

A review on the traditional uses, phytochemistry, and pharmacological activities of clove basil (Ocimum gratissimum L.)

A review on the traditional uses, phytochemistry, and pharmacological activities of clove basil (Ocimum gratissimum L.)

The effect of methanol extract of Piper guineense on paracetamol induced toxicity

Plastics, Food Security, and Sustainable Urbanization

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