Antiparasitic activity of aqueous extract of Anethum graveolens against Entamoeba histolytica: In vitro and in vivo study

Abas, Al-Shimaa M.; Elagib, Somia M.

doi:10.1016/j.bcab.2021.102026

Cited by 1 publication

(5 citation statements)

References 24 publications

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“…This finding is consistent with numerous in vivo human and animal studies that clearly illustrated the preventative or therapeutic potential of one or more of these alternatives. 13 , 18 , 34 Logically recovery of intestinal integrity and decreased oocysts multiplication correlate with the ability of the parasite to cause the disease manifestations.…”

Section: Discussionmentioning

confidence: 99%

“…The study revealed very promising anti-protozoal effects in comparison to metronidazole effects. 13 The thorough mechanism by which dill seed oil exhibited antiparasitic effects is undetermined and needs further studies. However, it could be the dill chemical structure and its major components, such as dillapiole and anethole, that form hydrogen bonds with the active site of the target enzymes.…”

Section: Dovepressmentioning

confidence: 99%

“…Syzygium aromaticum and Anethum graveolens seeds essential oil and extracts exerted anti-inflammatory activity against various microorganisms, including Entamoeba histolytica and Helicobacter pylori . 13 , 18 …”

Section: Introductionmentioning

confidence: 99%

“…11,12 In recent decades, medicinal plants have gained greater recognition due to the awareness that these plants have lesser side effects and improved efficacy than their synthetic counterparts. 13 Several studies documented variable degrees of antibacterial, antiviral, anticarcinogenic, antifungal, and antiparasitic activities of different herbs, including cinnamon, oregano, clove, thyme, dill, garlic, black seed, and mint. 14,15 However, Syzygium aromaticum, popular as clove and Anethum graveolens known as dill, gained much attention among other spices due to its strong antimicrobial, including antiparasitic and antioxidant properties.…”

Section: Introductionmentioning

confidence: 99%

“…Syzygium aromaticum and Anethum graveolens seeds essential oil and extracts exerted antiinflammatory activity against various microorganisms, including Entamoeba histolytica and Helicobacter pylori. 13,18 Nitazoxanide (NTZ) is used to treat cryptosporidiosis. It has a broad-spectrum parasiticidal activity approved by the US FDA for treating diarrhea in both children and adults.…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Commercially Available Syzygium aromaticum, Anethum graveolens, Lactobacillus acidophilus LB, and Zinc as Alternatives Therapy in Experimental Mice Challenged with Cryptosporidium parvum

Gaber¹,

Galal²,

Farrag³

et al. 2022

IDR

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Background Waterborne cryptosporidiosis is the second cause of diarrhea in young children and immunocompromised hosts after rotavirus. Except for nitazoxanide (NTZ), there is no accredited cryptosporidiosis treatment to date. Therefore, there is an urgent need to find an effective and safe treatment for cryptosporidiosis. This study aimed to investigate the possible anti-protozoal effects of Syzygium aromaticum (clove) oil, Anethum graveolens (dill) seeds oil, Lactobacillus acidophilus LB, and zinc against Cryptosporidium parvum in comparison to NTZ. Methods Besides the negative control, mice from six experimental groups (T1–T6) were infected with Cryptosporidium parvum oocysts. On the seventh day post-infection (PID), mice from five groups were treated for 8 consecutive days with NTZ, clove oil, dill seed oil, Lactobacillus acidophilus LB, and zinc commercial forms (T2–T5). Oocysts shedding rate, differences of mice body weight, serum IL10, and TNF-α, cryptosporidial antigen, and cd3 at the intestinal mucosa were evaluated at the end of the experiment. Results The mean of the C. parvum oocysts’ shedding rate was significantly lower in all treated groups than in the non-treated group. The oocysts reduction rate was the highest in zinc-treated mice (98.3%), Lactobacillus acidophilus LB and dill-treated groups (95.77%), and the NTZ-treated group (91.55%). Clove oil was the least effective, with a 74.65% reduction rate. Excluding the clove oil-treated group, immunohistochemical analysis revealed the clearance of the Cryptosporidium antigen in the intestinal tissue in all treated groups. Conclusion The study has provided a rational basis for using these safe, cheap, and commercially available alternatives in treating cryptosporidiosis combined with NTZ.

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Section: Discussionmentioning

confidence: 99%

Section: Dovepressmentioning

confidence: 99%