Antiparasitic activity of a triphenyl tin complex against Leishmania donovani

Raychaudhury, Bikramjit; Banerjee, Shouvik; Gupta, Shreedhara; Singh, Rajbir; Datta, Soma

doi:10.1016/j.actatropica.2005.03.008

Cited by 23 publications

(6 citation statements)

References 28 publications

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“…The metal complexes of coumarins and its derivatives are potential agents against various bacterial and fungal strains (Rehman et al, 2005 ). The tin complexes of different compounds are potential complexes in the management of leishmaniasis, free radicals scavenging, DNA interaction and as antimicrobial (Raychaudhury et al, 2005 ; Raza et al, 2016 ). The complexes of antimony have also a vital role in antimicrobial, antioxidant and anticancer activities (Viswanathan et al, 2000 ; Ejidike and Ajibade, 2015 ; Neelofar et al, 2016 ).…”

Section: Resultsmentioning

confidence: 99%

Ursolic Acid Hydrazide Based Organometallic Complexes: Synthesis, Characterization, Antibacterial, Antioxidant, and Docking Studies

et al. 2018

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In thecurrent research work,eleven metal complexes were synthesized from the hydrazide derivative of ursolic acid. Metal complexes of tin, antimony and iron were synthesized and characterized by FT-IR and NMR spectroscopy. The antibacterial and antioxidant activities were performed for these complexes, which revealed that the metal complexes synthesized are more potent than their parent compounds. We observed that antioxidant activity showed by triphenyltin complex was significant and least activity have been shown by antimony trichloride complex. The synthesized metal complexes were then evaluated against two Gram-negative and two Gram-positive bacterial strains. Triphenyl tin complex emerged as potent antibacterial agent with MIC value of 8 μg/ml each against Shigellaspp, Salmonella typhi and Staphylococcus aureus. While, the MIC value against Streptococcus pneumoniae is 4 μg/ml. Computational docking studies were carried out on molecular targets to interpret the results of antioxidant and antibacterial activities. Based on the results, it may be inferred that the metal complexes of ursolic acid are more active as compared to the parent drug and may be proved for some other pharmacological potential by further analysis.

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Section: Resultsmentioning

confidence: 99%

Ursolic Acid Hydrazide Based Organometallic Complexes: Synthesis, Characterization, Antibacterial, Antioxidant, and Docking Studies

et al. 2018

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“…21) [175] and (terpyridine)-platinum(II) complexes such as 79, which are effective against L. donovani (100% inhibition at 1 mM), T. cruzi (65% inhibition at 1 mM), and T. b. brucei (100% inhibition at 30 nM) [176]. The triphenyltin complex 80 also has antileishmanial activity, and depletes amastigotes in cultured hamster macrophages to undetectable levels at a concentration of 10 mg/L [177]. A wide variety of natural products have been isolated that exhibit antileishmanial activity, but few have been subjected to systematic SAR studies [178].…”

Section: Potential New Therapies For Leishmaniasismentioning

confidence: 96%

Antiprotozoal/Antiparasitic Agents

Woster

2010

Burger's Medicinal Chemistry and Drug Discovery

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Collectively, diseases caused by parasitic protozoa, including human African trypanosomiasis ( HAT ), Chagas' disease and leishmaniasis, threaten more than 550 million people worldwide and cause nearly 150,000 deaths annually. The causative organisms for these diseases are unicellular trypanosomatid parasites of the genera Trypanosoma brucei , Trypanosoma cruzi , and Leishmania sp., respectively. Drug therapies available for these diseases have not changed significantly in the past 50 years, and currently used agents are far less than satisfactory due to extreme toxicity, and because resistant parasitic strains are becoming more prevalent. These diseases are confined to impoverished or rural areas of Mexico, Central America, South America, sub‐Saharan Africa, the Middle East, Indonesia, and India. As such, drug discovery efforts against trypanosomatid diseases are limited because patients in underdeveloped areas cannot afford therapy, and because the infected population is too small to justify the required research expenditures. In addition, antiparasitic research in Third World nations is often hampered by economic issues and political turmoil, virtually assuring that the world's most impoverished people will continue to bear the major burden of parasitic disease. Clearly, there is a need for new anti‐infective agents that are potent, nontoxic and inexpensive to manufacture. In this chapter, the etiology of these diseases and their current treatment are described. The chapter also deals with medicinal chemistry aspects of efforts to identify new drug targets for parasitic diseases, and to produce novel inhibitors of trypanosomatid growth for use as antiparasitic agents.

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“…As an example, Triphenyl Tin salicylanilide thiosemicarbazone (TTST, 30), an organometallic complex of triphenyl tin, having chemical formula Ph 3 Sn(OSal$TSCZH, 30), was reported to have anti-leishmanial activity [54]. This complex was effective both in vitro and in vivo at lower concentrations compared to the existing toxic drugs available.…”

Section: Tin Complexesmentioning

confidence: 98%

Importance of metal complexes for development of potential leishmanicidal agents

Tahghighi

2014

Journal of Organometallic Chemistry

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Antiparasitic activity of a triphenyl tin complex against Leishmania donovani

Cited by 23 publications

References 28 publications

Ursolic Acid Hydrazide Based Organometallic Complexes: Synthesis, Characterization, Antibacterial, Antioxidant, and Docking Studies

Ursolic Acid Hydrazide Based Organometallic Complexes: Synthesis, Characterization, Antibacterial, Antioxidant, and Docking Studies

Antiprotozoal/Antiparasitic Agents

Importance of metal complexes for development of potential leishmanicidal agents

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