Antiparasitary and antiproliferative activities in vitro of a 1,2,4-oxadiazole derivative on Trypanosoma cruzi

Chemical representation learning for toxicity prediction

“…Some of these fragments can be linked to tremendous recent literature, for example bit 388 corresponds to a 1,2,4-oxadiazole ring. 1,2,4-Oxadiazole-derivatives have been largely neglected by medicinal chemistry until 2005, but in the past 15 years, research has grown exponentially 113 and only in 2022 researchers reported cytotoxic, 114 fungicidal, 115 anti-inflammatory, 114 antiparasitary and antiproliferative 116 effects of 1,2,4-oxadiazole derivatives.…”