Antioxydant and Endotheliotropic Properties 4-Hydroxy-3,5-Di-Tret-Butyl Cinnamic Acid under Conditions of Experimental Brain Ischemia

DI, Pozdnyakov Pozdnyakov; Av, Voronkov; DS, Zolotych Zolotych; Av, Arl't

doi:10.5530/jyp.2018.10.43

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…Similar activities (metabolic and antioxidant effects) have been described for 4-hydroxy-3,5-ditert-butyl cinnamic acid. For instance, Pozdnyakov et al (2018) noted that under conditions of cerebral ischemia, the use of ATACL at a dosage of 100 mg/ kg contributed to the normalization of pro/antioxidant equilibrium by increasing the activity of superoxide dismutase, catalase and glutathione peroxidase, as well as by suppressing free radical lipid oxidation reactions, which can indicate a decrease in the concentration of diene adducts and TBA-active compounds, when using 4-hydroxy-3,5-di-tert-butyl cinnamic acid. In this case, the metabolic action of the ATACL compound can be aimed at stabilizing the mitochondrial function, which is realized through the normalization of the activity of mitochondrial subcomplexes V (F 1 F 0 ATP synthase) and IV (cytochrome c oxidase) (Voronkov et al 2018).…”

Section: Discussionmentioning

confidence: 99%

Study of dose-dependent actoprotective effect of ATACL on physical performancend psychoemotional status of animals under exhausting exercise

Gerashchenko¹,

Поздняков²,

Voronkov³

2022

RRP

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Introduction: The aim of the study was to investigate the dose-dependent actoprotective effect of ATACL on physical performance and psychoemotional status of animals under conditions of exhausting exercise. Materials and methods: Outbred male mice (23–25 g) were used in the experiment. The test compound in various dosages, as well as the reference drug, were administered intragastrically 60 minutes before the forced swimming test for 10 days of the experiment. At the end of the physical activity, the psychoemotional status of the animals was assessed in the Open Field (OF) and Elevated plus maze (EPM) tests. Results and discussion: In the course of the experiment, it was found that under conditions of exhausting physical execise, a smooth increase in performance was observed in the group that had received the test compound 4-hydroxy-3,5-di-tert butyl cinnamic acid (ATACL) at a dosage of 100 mg/kg for 10 days. The peak of performance was recorded on the 8th day, which was 47.3% (p<0.05) higher than the physical activity of the mice treated with the reference drug ethylthiobenzimidazole hydrobromide (EBH). When assessing changes in the Open Field test, it was found that the test compound ATACL at a dosage of 100 mg/kg is also a leader in stabilizing the psychoemotional status of the animals, which is reflected in the improvement of the motor activity (the number of sectors crossed by 4.7 times (p< 0.05)), exploratory activity (an increase in the number of «peeps» and rearings by 8.5 times (p<0.05) and 12.7 times (p<0.05), respectively) and changes in the level of anxiety (a 2.5-time decrease in the number of short-term grooming acts (p<0.05)) in comparison with the negative control (NC) group. The results obtained in the EPM test are completely consistent with the results of the OF test; the most pronounced activity was observed for the ATACL compound at a dosage of 100 mg/kg. Conclusion: Based on the combination of reproducible methods, it can be concluded that the most pronounced actоprotective effect is exerted by the compound at a dosage of 100 mg/kg, not inferior, at the same time, to the reference drug EBН. Graphical abstract:

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Section: Discussionmentioning

confidence: 99%

Study of dose-dependent actoprotective effect of ATACL on physical performancend psychoemotional status of animals under exhausting exercise

Gerashchenko¹,

Поздняков²,

Voronkov³

2022

RRP

View full text Add to dashboard Cite

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Neuroprotective Activities of Cinnamic Acids and their Derivatives

Biswas

Yadav

Jain

2023

Frontiers in Clinical Drug Research - CNS and Neurological Disorders

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Neurodegenerative disorders are considered major global health problems associated with nervous system dysfunction, progressive neuronal cell loss with aging, and several pathological and sporadic factors. Parkinson’s disease, Alzheimer’s disease, Prion disease, Huntington’s disease, and multiple sclerosis are the main neurodegenerative diseases that raise significant concern among health scientists. The etiology of different neurodegenerative diseases is different, and they majorly affect the nervous system, including the brain, spinal cord, and peripheral nervous system. Neurodegenerative diseases are linked with motor dysfunction, anxiety, memory loss, depression, cognitive impairments, etc. These diseases can be hereditary or caused by toxicity, metabolic disorders, or pathological changes in the brain. Therefore, interest has been growing in the development of different neuroprotective agents of natural origin that could work effectively against these diseases. In that aspect, phytochemicals have shown high potential with minimal side effects in various in vitro and in vivo studies. Cinnamic acids with phenylpropenoic moiety are abundant in many natural resources. These are available in many forms, such as ferulic acid, caffeic acid, etc. They also have a variety of pharmacological properties, including anti-inflammatory, anti-oxidant, anti-amyloid, and neuroprotective properties. This chapter summarizes the role of naturally occurring cinnamic acids and their derivatives to develop the mechanistic aspects of neuroprotective therapeutics in neurodegenerative diseases. Future challenges are also discussed to provide beneficial information and therapeutic strategies.

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Antioxydant and Endotheliotropic Properties 4-Hydroxy-3,5-Di-Tret-Butyl Cinnamic Acid under Conditions of Experimental Brain Ischemia

Cited by 2 publications

References 6 publications

Study of dose-dependent actoprotective effect of ATACL on physical performancend psychoemotional status of animals under exhausting exercise

Study of dose-dependent actoprotective effect of ATACL on physical performancend psychoemotional status of animals under exhausting exercise

Neuroprotective Activities of Cinnamic Acids and their Derivatives

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