Antioxidative, Tyrosinase Inhibiting and Antibacterial Activities of Leaf Extracts from Medicinal Ferns

Lai, How Yee; Lim, Yau Yan; Tan, Shiau Pin

doi:10.1271/bbb.90018

Cited by 76 publications

(47 citation statements)

References 23 publications

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“…Similar observations were made in other studies which evaluated the antibacterial efficacy of ferns and other plants (Chew et al2009; Lai et al2009). The insensitivity of Gram-negative bacteria against antibacterial agents is attributable to the permeability barrier posed by the outer membrane of the bacteria and efficient multidrug efflux pumps traversing the bacterial membranes (Delcour2009; Li and Nikaido2009).…”

Section: Discussionsupporting

confidence: 87%

Antibacterial, anti-glucosidase, and antioxidant activities of selected highland ferns of Malaysia

et al. 2013

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BackgroundFerns contain natural products with potential therapeutic applications. Current knowledge of the pharmacological properties of ferns, specifically those growing at high altitudes, is limited. This study aimed to evaluate the phytochemical contents as well as antibacterial, anti-glucosidase, and antioxidant activities of four highland ferns in Malaysia.ResultsAqueous extracts of the leaves and rhizomes of Cyathea latebrosa, Dicranopteris curranii, Gleichenia truncata, and Phymatopteris triloba were analysed. P. triloba leaf extract had the highest contents of total flavonoids (118.6 mg/g dry matter), hydroxycinnamic acids (69.7 mg/g dry matter), and proanthocyanidins (29.4 mg/g dry matter). P. triloba leaf and rhizome extracts as well as G. truncata leaf extract inhibited the growth of both Gram-positive and Gram-negative bacteria. P. triloba leaf extract produced a minimum inhibitory concentration (MIC) value of 0.78 mg dry matter/mL when tested against Pseudomonas aeruginosa, which is 2.5-fold higher than that of ampicillin. Among all extracts, P. triloba leaf extract had the highest anti-glucosidase activity (EC50 = 56 μg dry matter/mL) and also the highest antioxidant potential based on DPPH radical scavenging and Ferric Reducing Antioxidant Power assays. Antioxidant activities of both the leaf and rhizome extracts correlated positively with total flavonoid and hydroxycinnamic acid contents (R2 = 0.80–0.95). On the other hand, anti-glucosidase activity correlated with total proanthocyanidin contents in both the leaf and rhizome extracts (R2 = 0.62–0.84).ConclusionsIn conclusion, highland ferns are potential sources of antibacterial agents, glucosidase inhibitors, and antioxidants.Electronic supplementary materialThe online version of this article (doi:10.1186/1999-3110-54-55) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 87%

Antibacterial, anti-glucosidase, and antioxidant activities of selected highland ferns of Malaysia

et al. 2013

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“…The higher susceptibility of gram positive bacteria to plant extracts is consistent with previous findings (Lai et al, 2009;Johnson et al, 2012;Ahmad et al, 1998).…”

Section: Discussionsupporting

confidence: 92%

Antimicrobial activity of ethanolic and aqueous extracts of medicinally used tree ferns Alsophila cuspidata and Cyathea microdonta

Longtine¹,

Tejedor²

2018

abm

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Resumen Actividad antimicrobiana de extractos en etanol y agua de los helechos arborescentes usados medicinalmente Alsophila cuspidata y Cyathea microdontaLas plantas medicinales son componentes importantes de farmacologías tradicionales y fuentes de compuestos antimicrobianos que pueden combatir patógenos resistentes a antibióticos comerciales. Este estudio examinó la actividad antimicrobiana de extractos en etanol y agua de dos helechos aborescentes Neotropicales usados medicinalmente (Alsophila cuspidata y Cyathea microdonta) frente a bacterias grampositivas y gramnegativas usando el método de difusión de Kirby-Bauer. La mayor actividad antimicrobiana se observó en extractos en etanol y frente a bacterias grampositivas. No hubo diferencias entre especies de helechos o entre extractos obtenidos de frondes, peciolos, o troncos. Estos resultados sugieren que el uso tradicional del mucílago de helechos arborecentes como agente tópico en cortes y lesiones de leishmaniasis pueden reducir el riesgo de infecciones con bacterias cutáneas como Staphylococcus aureus y que las Cyatheaceae Neotropicales son una fuente potencial de compuestos antimicrobianos novedosos.Palabras clave: Helechos arborescentes, medicina tradicional, Amazonia peruana, Kirby-Bauer. AbstractMedicinal plants are important components of traditional medicine and sources of novel antimicrobial compounds against drug resistance pathogen strains. This study tested the antimicrobial activity of ethanolic and aqueous extracts of medicinally used Neotropical tree ferns Cyathea microdonta and Alsophila cuspidata against gram positive bacteria and gram negative bacteria using the Kirby-Bauer disc diffusion method. Highest antimicrobial activity was observed in ethanolic extracts, and extracts were more active against gram positive bacteria than gram negative bacteria. No difference was observed in antimicrobial activity between species or between extracts made from the leaves, stipe, or caudex. These results suggest that the traditional use of tree fern mucilage as a topical agent for cuts and leishmaniasis lesions may reduce risk of secondary infection with skin bacteria such as Staphylococcus aureus, and that Neotropical Cyatheaceae are a potential source of novel antimicrobial compounds.

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“…To the best of our knowledge, this is the first record of mangiferin and mangiferin glucoside in gametophytes of ferns in general. In the recent years, much attention has been devoted to ferns as potential sources of natural antioxidants, and several Asplenium species have been evaluated for their antioxidant potential (Lai et al, 2009;Talukdar et al, 2011;Ondo et al, 2013;Andrade et al, 2014). High superoxide anion and nitric oxide radical scavenging activities have been determined for A. ceterach, as well as significant radical scavenging activity against DPPH radical (Berk et al, 2011;Karadeniz et al, 2015).…”

Section: Resultsmentioning

confidence: 99%

Phytochemical characterization and antioxidant potential of rustyback fern (Asplenium ceterach L.)

Živković¹,

Škorić²,

Šiler³

et al. 2017

Lek sirovine

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Asplenium ceterach L. (syn. Ceterach officinarum Willd.) or rustyback fern is a plant species traditionally used in Mediterranean countries as an expectorant, diuretic, against spleen complaints, kidney stones and hemorrhoids. Phytochemical analysis of gametophytes and sporophytes of A. ceterach was performed, followed by comparative analysis of phenolic composition and the antioxidant properties of the extracts (scavenging capacities against ABTS• + and DPPH•). Totally 16 phenolic compounds belonging to the classes of phenolic acids (hydroxybenzoic and hydroxycynnamic acids), flavonoids (flavan-3-ols, flavonols), and xanthones were identified using UHPLC/DAD/-HESI-MS/MS analysis. Different phenolics' composition of the two phases of the life cycle of this fern was observed which significantly determined their radical scavenging activities. In sporophytes of A. ceterach considerably high amounts of chlorogenic acid were found (~21 µg 100 mg -1 fresh weight), while xanthones were the most abundant in gametophytes (mangiferin glucoside, reaching 2.54 µg 100 mg -1 fresh weight), recommending this fern species as a valuable source of bioactive compounds.

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Antioxidative, Tyrosinase Inhibiting and Antibacterial Activities of Leaf Extracts from Medicinal Ferns

Cited by 76 publications

References 23 publications

Antibacterial, anti-glucosidase, and antioxidant activities of selected highland ferns of Malaysia

Antibacterial, anti-glucosidase, and antioxidant activities of selected highland ferns of Malaysia

Antimicrobial activity of ethanolic and aqueous extracts of medicinally used tree ferns Alsophila cuspidata and Cyathea microdonta

Phytochemical characterization and antioxidant potential of rustyback fern (Asplenium ceterach L.)

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