Antioxidative mechanisms and anticolitic potential of Desmodium styracifolium (Osb.) Merr. in DSS-induced colitic mice

Li, Xia; Liu, Chengxin; Liang, Jun; Zhou, Li; Li, Jing; Jiang, Tiemin; Guan, Yuan; Khoo, Hock Eng

doi:10.1016/j.jff.2022.105077

Cited by 8 publications

(25 citation statements)

References 30 publications

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“…Anthocyanins have been reported to scavenge free radicals via electron transfer reaction pathway, and the mechanism involves regulation of antioxidant enzyme such as SOD ( Khoo et al, 2017 ). Bioactive compounds containing catechol group have higher antioxidant activities ( Li et al, 2022 ). These phytochemicals found in litchi peels help to retard the fruit senescence besides the exogenous melatonin.…”

Section: Discussionmentioning

confidence: 99%

Melatonin treatment improves postharvest quality and regulates reactive oxygen species metabolism in “Feizixiao” litchi based on principal component analysis

et al. 2022

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Postharvest quality of litchi reduces rapidly during storage at room temperature. This study aimed to investigate the effect of melatonin treatment on postharvest quality and oxidative stress markers of litchi fruit during cold storage. The “Feizixiao” litchi was treated with melatonin solution concentrations of 0.2 and 0.6 mmol·L−1 and then stored at 4°C for 12 days. The results confirmed that the melatonin treatment effectively maintained the appearance and color of the litchi fruit, suppressed the peel browning, and improved the litchi quality. The treatment also significantly enhanced the levels of endogenous melatonin, antioxidant components (total phenolics, flavonoids, and anthocyanin), and antioxidant enzyme activities of the fruit. It also inhibited the other oxidative stress markers, such as O2−, H2O2, MDA, and protein carbonyl content, and upregulated the expressions of antioxidant and Msr-related genes. Correlation and principal component analyses further confirmed that the melatonin treatment effectively delayed the fruit senescence by enhancing the antioxidant enzyme activities and modulating peel browning and reactive oxygen species metabolism of the litchi fruit via regulating gene expression of the related enzymes (SOD and PPO). These findings suggested that the exogenous application of melatonin to litchi during the postharvest is an ideal way to preserve the fruit quality and delay fruit senescence.

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Section: Discussionmentioning

confidence: 99%

Melatonin treatment improves postharvest quality and regulates reactive oxygen species metabolism in “Feizixiao” litchi based on principal component analysis

et al. 2022

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“…Polyphenols and alkaloids are considered the primary components responsible for the majority of the pharmacological effects of plants in this genus [ 5 , 15 , [20] , [21] , [22] ]. Table 2 demonstrates a list of compounds isolated from plants of the D. styracifolium species, according to literature data [ 5 , 14 , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] ]. The greatest importance in the phamacological action of D. styracifolium have following polyphenols: apigenin (IUPAC: 5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one), genistein (IUPAC: 5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one), kaemferol (IUPAC: 3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one), luteolin (IUPAC: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one), quercetin (IUPAC: 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one), and shaftoside (IUPAC: 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-[(2R,3R,4R,6S, 7R)-3,4,6-trihydroxy-7-(hydroxymethyl)oxan-2-yl]-8-[(2S,3R,4S, 6S)-3,4,6-trihydroxyoxan-2-yl]chromen-4-one).…”

Section: Phytochemical Studiesmentioning

confidence: 99%

“… Ambonin Aerial parts [ 7 , 37 ] 11. Apigenin Whole plant/Aerial parts [ 7 , 26 , 28 , 29 ] 12. Astragalin Aerial parts [ 7 , 37 ] 13.…”

Section: Phytochemical Studiesmentioning

confidence: 99%

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Desmodium styracifolium: Botanical and ethnopharmacological insights, phytochemical investigations, and prospects in pharmacology and pharmacotherapy

Opryshko,

Prokhach,

Akimov

et al. 2024

Heliyon

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“…Moreover, the comparison of double BDE with BDE indicated that in the gas phase, 3-OH can be activated by 4′-O⋅ to scavenge free radicals through the double HAT mechanism [39,40]. Furthermore, IPs were greatly affected by the solvent effect, and in the polar solvent (ethanol and water) systems, the IP values were significantly lower than BDEs and PAs, indicating that the SET-PT mechanism was more likely to occur [41]. By comparing PA and proton dissociation enthalpy, it can be found that the proton transfer ability of neutral molecules was worse than that of phenoxy cationic radicals.…”

Section: Theoretical Mechanismmentioning

confidence: 99%

Elution–extrusion counter‐current chromatographic separation and theoretical mechanism of antioxidant from Robinia pseudoacacia flower

Liu

Zhang

Tang

et al. 2023

J of Separation Science

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Robinia pseudoacacia flowers have attracted much attention because of numerous bioactivities. In this study, its extract showed the potential scavenging ability for 2,2′-azinobis-(3-ethylbenzthiazoline-6-sulphonate) and 1,1-diphenyl-2-picrylhydrazyl free radicals. Under the guidance of antioxidant activity, the antioxidant extract was enriched by liquid-liquid extraction. The partition coefficients of the two main components in antioxidant extracts differed greatly, so in this study, elution-extrusion counter-current chromatography with the solvent system of n-hexane-ethyl acetate-methanol-water (2.5:5:2.5:5, v/v) was used to enhance the separation efficiency, and the two main components were successfully obtained. Among them, kaempferol showed strong antioxidant activity, which can be responsible for the activity of the extract. In order to deeply understand the antioxidant mechanism of kaempferol, the thermodynamics, frontier molecular orbital, and kinetics of scavenging free radicals were investigated by density functional theory. The results showed that 4′-OH in kaempferol was the most active group, which can scavenge free radicals by hydrogen atom transfer in non-polar solvents and activate 3-OH to generate double hydrogen atom transfer in the gas phase. But in polar solvents, it was more inclined to clear radicals through single electron transfer and proton transfer. The kinetic result showed that kaempferol needed 9.17 kcal/mol of activation energy to scavenge free radicals.

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Antioxidative mechanisms and anticolitic potential of Desmodium styracifolium (Osb.) Merr. in DSS-induced colitic mice

Cited by 8 publications

References 30 publications

Melatonin treatment improves postharvest quality and regulates reactive oxygen species metabolism in “Feizixiao” litchi based on principal component analysis

Melatonin treatment improves postharvest quality and regulates reactive oxygen species metabolism in “Feizixiao” litchi based on principal component analysis

Desmodium styracifolium: Botanical and ethnopharmacological insights, phytochemical investigations, and prospects in pharmacology and pharmacotherapy

Elution–extrusion counter‐current chromatographic separation and theoretical mechanism of antioxidant from Robinia pseudoacacia flower

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