Antioxidative in vitro and antiosteoporotic activities of Prinsepia utilis Royle in female rats

Goyal, Rohit; Bhattacharya, Shoumyo; Dhar, K.L.

doi:10.1016/j.eujim.2014.10.002

Cited by 23 publications

(18 citation statements)

References 29 publications

(30 reference statements)

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“…The surgical ovariectomy in female rodents is a valid method to characterize the symptoms of osteoporosis and used to test the efficacy of new therapeutic agents [ 39 , 40 ]. Surgical removal of both the ovaries in female rat causes decrease in estrogen level and the state is also attributed with an increase in body weight, decrease in bone mineral density, deterioration of bone integrity & architecture, increase in intertrabecular spaces or narrowing of bone marrow spaces as in ovariectomized animals.…”

Section: Discussionmentioning

confidence: 99%

“…No adverse or toxic symptoms were observed under behavioral and biochemical assessments for 1st day, 2, 4 and up to 14 days and both the extracts were found to be safe at 2000 and 5000 mg/kg. The methanolic extract of stem bark of B. ceiba has previously been reported to be safe orally in acute toxicity study conducted by our research group and found effective against high fat-induced obesity at 100 and 200 mg/kg in rodents [ 39 ]. In the present study, the two dose levels: 100 and 200 mg/kg p.o.…”

Section: Methodsmentioning

confidence: 99%

“…Osteoporosis was induced by a surgical ovariectomy method as described by Gupta et al [ 39 , 40 ]. Female Wistar albino rats were employed and divided into eight groups, each comprising six animals ( n = 6).…”

Section: Methodsmentioning

confidence: 99%

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In-vitro osteoblast proliferation and in-vivo anti-osteoporotic activity of Bombax ceiba with quantification of Lupeol, gallic acid and β-sitosterol by HPTLC and HPLC

Chauhan

Sharma

Upadhyay

et al. 2018

BMC Complement Altern Med

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BackgroundBombax ceiba is used traditionally to treat bone disorders, rheumatism, and joint pain. The aim of the study is to carry out osteogenic activity in-vitro and anti-osteoporotic activity in-vivo of stem bark of B. ceiba in surgical ovariectomy model in female rats.MethodsPlant drug: B. ceiba stem bark was extracted with solvents petroleum ether and methanol using Soxhlet extraction. In-vitro osteoblastic proliferation study was performed using UMR-106 cell lines. Both the extracts were undergone to acute toxicity study as per OECD423 guidelines. Female Wistar albino rats 180-240 g were used (n = 6). Surgical ovariectomy was performed under anesthesia to induce bone porosity and loss in all animals except normal control and sham control. Each extract was administered at two dose level: 100 and 200 mg/kg and the standard Raloxifene was given at 1 mg/kg orally for 28 days. The phytochemical study of both the extracts was performed using HPLC and HPTLC.ResultsA significant osteoblast cell proliferation and alkaline phosphatase activity were observed with B. ceiba extracts in UMR-106 cell lines. Surgical removal of ovaries produced significant (p < 0.05) decline in bone mineral density, bone breaking strength, serum ALP, calcium, phosphorus, and estradiol level and marked bone tissue destruction in histology. Administration of petroleum ether and methanolic extract for 28 days significantly (p < 0.05) ameliorated the consequences of ovariectomy induced bone porosity and restored the normal architecture of bone, as compared to OVX control. The phytochemical screening of both the extracts were also carried out. The quantification of phytoconstituents showed the presence of β-sitosterol and lupeol in petroleum ether extract, whereas the lupeol is also quantified in the methanolic extract. The presence of gallic acid was quantified in methanolic extract using HPLC.ConclusionB. ceiba: stem bark ameliorated the state of bone fragility and fracture possibly due to estrogenic modulation, as also confirmed by in-vitro osteogenic activity which may be due to the presence of lupeol, gallic acid and β-sitosterol constituents of the plant.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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In-vitro osteoblast proliferation and in-vivo anti-osteoporotic activity of Bombax ceiba with quantification of Lupeol, gallic acid and β-sitosterol by HPTLC and HPLC

Chauhan

Sharma

Upadhyay

et al. 2018

BMC Complement Altern Med

Self Cite

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“…It can protect the gastric mucosa and is a good treatment for dry skin. Thus, P. utilis has great potential for development as a raw material for natural skin care and health care products [56].…”

Section: Commercial Potentialmentioning

confidence: 99%

Medicinal dietary plants of the Yi in Mile, Yunnan, China

Sun

Xiong

et al. 2020

J Ethnobiology Ethnomedicine

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Background: The Yi is the largest ethnic group in Yunnan Province (China), with a population of five million. The Yi people tend to live in mountainous areas, and their culture includes a unique dietary system for treating and protecting people against illnesses. Medicinal plants occupy an essential place in the Yi diet because they play a key role in health and the prevention and treatment of diseases. However, few studies have addressed these medicinal dietary plants and their importance in the Yi's daily lives. The aim of this study was to (1) investigate the medicinal dietary plants used by the Yi in Mile City, (2) document the traditional knowledge held about these plants, (3) identify species with important cultural significance to the Yi in Mile City, and (4) analyze the special preparation methods and consumption habits of these plants. Methods: Field investigations were performed in six villages in Mile City, Honghe Hani and Yi Autonomous Prefecture, Yunnan, from July 2017 to May 2018. Information was collected using direct observation, semi-structured interviews, key informant interviews, individual discussions, and focus group discussions. The use value (UV) and frequency of utilization index (FUI) of these plants were analyzed. Plant samples and voucher specimens were collected for taxonomic identification. Results: This study documented 124 species belonging to 62 families and 102 genera. These plants included angiosperms (117 spp.), gymnosperms (3), pteridophytes (2), lichen (1), and fungus (1). The 20 species with the highest UV were noted as being particularly important to the Yi people's daily life in Mile City. The primary medicinal preparation method for plants recorded in the study was decoction. The most commonly used plant parts were fruits and roots. The most frequently used edible parts were fruits, and the most frequently used medicinal parts were roots. The medicinal parts were used to treat diseases such as rheumatism, edemas, kidney deficiency, spleen deficiency, gastritis, parasites, and so on.

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“…can protect the gastric mucosa and is a good treatment for dry skin. Thus P. utilis has great potential for development as a raw material for natural skin-care and health-care products [42].…”

Section: Medicinal and Edible Plants Worldwidementioning

confidence: 99%

Ethnobotanical study on medicinal dietary plants used by the Yi people in southeastern Yunnan, China

Sun

Xiong

et al. 2020

Preprint

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Background With a population of more than 5 million, Yi is the largest of the 25 ethnic groups in Yunnan Province, China. Yi people tend to live in mountainous areas, and their culture includes a unique dietary system for treating illnesses and protecting people against them. Medicinal plants occupy an essential place in the Yi diet because they play a key role in health and the prevention and treatment of diseases. The objectives of this paper were to document the medicinal dietary plants and the traditional knowledge associated with them and describes this paper adequately. Methods Field investigations were carried out in six villages in Mile County, Honghe Hani and Yi Autonomous Prefecture, Yunnan, from July 2017 to May 2018. Information was collected using participatory rural appraisal (PRA), direct observation, semi-structured interviews, key informant interviews, individual discussions, focus group discussions, and questionnaires. Results The study documented 124 species belonging to 62 families and 102 genera. These included: angiosperms (117 spp.), gymnosperms (3), pteridophytes (2), lichens (1), and fungi (1). The most commonly used plant parts were fruits and roots. The most frequently used edible parts were fruits, and the most frequently used medicinal parts were roots. The medicinal parts were used to treat conditions such as cough, catarrh, rheumatism, swelling, kidney deficiency, spleen deficiency, gastric disease, and others. Some of the plants required special preparation. Several had good economic potential due to their significant effects. In addition, a number of these plants are scarce and require conservation. The use-value (UV) and frequency of utilization index (FUI) of medicinal dietary plant species were analyzed. The 20 species with the highest UV were noted as particularly important to the Yi people’s daily life in Mile county. Conclusion A wide variety of medicinal dietary plants is used by Yi people in Mile. These plants occupy an essential position in the Yi diet and medicine. These plants are not only nutritious but also have medicinal value and, by consuming them, the Yi people maintain health and treat diseases through their daily diet. Ethnobotanical surveys of medicinal dietary plants provide a theoretical reference for the conservation and sustainable use of these plant resources and can contribute to the protection of the Yi food culture and traditional medicine in Mile. In addition, this information provides a basis for the development and utilization of Yi ethnic medicine and health products.

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Antioxidative in vitro and antiosteoporotic activities of Prinsepia utilis Royle in female rats

Cited by 23 publications

References 29 publications

In-vitro osteoblast proliferation and in-vivo anti-osteoporotic activity of Bombax ceiba with quantification of Lupeol, gallic acid and β-sitosterol by HPTLC and HPLC

In-vitro osteoblast proliferation and in-vivo anti-osteoporotic activity of Bombax ceiba with quantification of Lupeol, gallic acid and β-sitosterol by HPTLC and HPLC

Medicinal dietary plants of the Yi in Mile, Yunnan, China

Ethnobotanical study on medicinal dietary plants used by the Yi people in southeastern Yunnan, China

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