Antioxidative effects of Rooibos tea on workers occupationally exposed to lead

Effects of rooibos (Aspalathus linearis) on oxidative stress and biochemical parameters in adults at risk for cardiovascular disease

“…However, the mechanisms may differ, since a notable increase in GSH was also seen with rooibos but not with Camellia sinensis in that study (Marnewick et al, 2003). Results from the current study concur with this, and also with another human study reporting a significant increase (47.8%) in the levels of GSH (Nikolova et al, 2007). Reduced glutathione is a powerful intracellular antioxidant that plays a vital role in stabilizing various enzymes and can also be considered a good marker for tissue antioxidant capacity (Van Acker et al, 2000;Wang and Jiao, 2000).…”

“…Rooibos has been shown to be antimutagenic (Marnewick et al, 2000(Marnewick et al, , 2004, cancer modulating (Marnewick et al, 2005 and to regenerate coenzyme Q10 with the resultant inhibition of lipid peroxidation in rat liver (Kucharska et al, 2004). More recently, an 8-week randomized placebo-controlled intervention study reported on the antioxidant status of lead factory workers after drinking traditional, fermented rooibos (Nikolova et al, 2007). Modulation of the redox status of these workers was shown by a decreased level of lipid peroxidation [measured as malondialdehyde (MDA) in the plasma] and an increased level of blood glutathione (GSH).…”

Protective Effects of Rooibos (Aspalathus Linearis) and/or Red Palm Oil (Elaeis Guineensis) Supplementation on Tert-Butyl Hydroperoxide-Induced Oxidative Hepatotoxicity in Wistar Rats

“…Previous reports have indicated that rooibos reduced age-related lipid peroxide accumulation (measured as TBARS) in the brain of overage rats consuming the tea for 21 months and inhibited MDA formation in rat tissues and liver microsomal preparations [31,72,92,96]. Recent reports in humans also revealed that rooibos consumption significantly decreased plasma MDA levels in lead factory workers [27] and also significantly lowered plasma CD and MDA levels in adults at the risk for cardiovascular diseases taking 6 cups of rooibos per day for 6 weeks [28]. The ability of rooibos to protect against lipid peroxidation may involve one or more of several different antioxidant properties exhibited by rooibos or synergistic interactions of its different phenolic constituents.…”

“…Its antioxidant [25,71], anti-inflammatory [34], anti-diabetic [35], and abilities to modulate oxidative stress [27,28,37,72] have been demonstrated in animal models and human studies. Red palm oil is rich in cocktail of lipid soluble antioxidants such as -and -carotene, lycopene, tocopherols ( , , , and isoforms), tocotrienols ( , , , and isoforms) and coenzyme Q 10 [47,73].…”

“…Polyphenolic constituents identified in rooibos include aspalathin (major polyphenol and unique only to rooibos), nothofagin, quercetin, rutin, isoquercitrin, orientin, luteolin, vitexin, and chrysoeriol [23,24]. The antioxidant properties of rooibos have been confirmed both in vitro and in vivo [25][26][27][28]. Rooibos has been shown to be antimutagenic [29,30], cancer modulating [31][32][33], antiinflammatory [34], antidiabetic [35], cardioprotective [36], and modulating oxidative stress [27,28,37].…”