Antioxidative Effects of Monoterpenes (1.8-Cineol) Compared with Budesonide (BUD) on Superoxide (O<sub>2</sub><sup>-</sup>) Production in Human Monocytes: New Evidence for Co-Medication in COPD and Sinusitis.

Ur, Juergens; Racké, Kurt; Tuleta, Izabela; Skowasch, Dirk; Stöber, Meinolf; Gillissen, Adrian; Nickenig, Georg

doi:10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a4584

Cited by 2 publications

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“…The GC/MS analysis showed tairin and shima EOs contain the major components of monoterpenes and sesquiterpenes. Previous studies have been reported that monoterpenes, such as terpinen-4-ol, 1,8-cineol, and γ-terpinene, showed anti-oxidant activities [11,12,25,26]. The strong anti-oxidant activity from tairin and shima EOs may be attributed from these components.…”

Section: Resultsmentioning

confidence: 99%

Anti-Oxidant, Anti-Aging, and Anti-Melanogenic Properties of the Essential Oils from Two Varieties of Alpinia zerumbet

Tawata

2015

Molecules

100

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Here, we investigated the anti-oxidant and anti-aging effects of essential oils (EOs) from the leaves of Alpinia zerumbet (tairin and shima) in vitro and anti-melanogenic effects in B16F10 melanoma cells. The anti-oxidant activities were performed with 2,2-diphenyl-1-picrylhydrazyl (DPPH); 2,2ʹ-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS); nitric oxide; singlet oxygen; hydroxyl radical scavenging; and xanthine oxidase. The inhibitory activities against collagenase, elastase, hyaluronidase, and tyrosinase were employed for anti-aging. The anti-melanogenic was assessed in B16F10 melanoma cells by melanin synthesis and intracellular tyrosinase inhibitory activity. The volatile chemical composition of the essential oil was analyzed with gas chromatography-mass spectrometry (GC/MS). The EO was a complex mixture mainly consisting of monoterpenes and sesquiterpenes. The results revealed that tairin and shima EOs showed strong anti-oxidant activities against DPPH and nitric oxide, hydroxyl radical scavenging activity, and xanthine oxidase inhibition. Compared to shima EO; tairin EO exhibited strong anti-aging activity by inhibiting collagenase, tyrosinase, hyaluronidase, and elastase (IC50 = 11 ± 0.1; 25 ± 1.2; 83 ± 1.6; and 213 ± 2 μg/mL, respectively). Both EOs inhibited intracellular tyrosinase activity; thus, reducing melanin synthesis. These results suggest that tairin EO has better anti-oxidant/anti-aging activity than shima EO, but both are equally anti-melanogenic.

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Section: Resultsmentioning

confidence: 99%

Anti-Oxidant, Anti-Aging, and Anti-Melanogenic Properties of the Essential Oils from Two Varieties of Alpinia zerumbet

Tawata

2015

Molecules

100

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“…Among them, terpinen-4-ol (17.32%), 1,8-cineol (22.40%), c-terpinene (11.42%) and sabinene (9.90%) were the major compounds (Table 1). There are reports that these monoterpenes show antioxidant activities (Grassmann, 2005;Juergens et al, 2009), and thus, it is likely that these compounds also contribute to the antioxidant effect of EO.…”

Section: Discussionmentioning

confidence: 99%

Genetic toxicology evaluation of essential oil of Alpinia zerumbet and its chemoprotective effects against H2O2-induced DNA damage in cultured human leukocytes

Cavalcanti

Ferreira

Cabral

et al. 2012

Food and Chemical Toxicology

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Essential oil (EO) of Alpinia zerumbet leaves, at non-toxic concentrations (50-300 μg/mL), did not induce genotoxicity in human leukocytes. However, at the highest concentration (500 μg/mL) tested caused a reduction in cell proliferation and viability, and an increase in DNA damage. Moreover, in vivo experiments showed that EO (400 mg/kg) did not exert mutagenicity on peripheral blood cells and bone marrow in mice. In DPPH test, EO showed scavenging effects against DPPH radicals, and other free radicals (determination of intracellular GSH and lipid peroxidation assays). Furthermore, EO was able to reduce the intracellular levels of ROS, and prevented leukocytes DNA against oxidative damage. The ability of EO to reduce H(2)O(2) toxicity was observed only when cells were treated with EO during and after exposure to H(2)O(2). With the co- and post-treatment procedures, EO decreased the frequency of apoptotic and micronucleated leukocytes as well DNA strand breaks. However, a synergistic effect was observed in cultures exposed to 500 μg/mL EO. In conclusion, EO at concentrations up to 300 μg/mL or doses up to 400mg/kg are not mutagenic in leukocytes and in mice, but do have antioxidative and protective effects against the cytotoxicity and clastogenesis induced by H(2)O(2).

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Antioxidative Effects of Monoterpenes (1.8-Cineol) Compared with Budesonide (BUD) on Superoxide (O₂^-) Production in Human Monocytes: New Evidence for Co-Medication in COPD and Sinusitis.

Cited by 2 publications

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Anti-Oxidant, Anti-Aging, and Anti-Melanogenic Properties of the Essential Oils from Two Varieties of Alpinia zerumbet

Anti-Oxidant, Anti-Aging, and Anti-Melanogenic Properties of the Essential Oils from Two Varieties of Alpinia zerumbet

Genetic toxicology evaluation of essential oil of Alpinia zerumbet and its chemoprotective effects against H2O2-induced DNA damage in cultured human leukocytes

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Antioxidative Effects of Monoterpenes (1.8-Cineol) Compared with Budesonide (BUD) on Superoxide (O2-) Production in Human Monocytes: New Evidence for Co-Medication in COPD and Sinusitis.

Cited by 2 publications

References 0 publications

Anti-Oxidant, Anti-Aging, and Anti-Melanogenic Properties of the Essential Oils from Two Varieties of Alpinia zerumbet

Anti-Oxidant, Anti-Aging, and Anti-Melanogenic Properties of the Essential Oils from Two Varieties of Alpinia zerumbet

Genetic toxicology evaluation of essential oil of Alpinia zerumbet and its chemoprotective effects against H2O2-induced DNA damage in cultured human leukocytes

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Product

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Antioxidative Effects of Monoterpenes (1.8-Cineol) Compared with Budesonide (BUD) on Superoxide (O₂^-) Production in Human Monocytes: New Evidence for Co-Medication in COPD and Sinusitis.