Antioxidative effects of melatonin administration in elderly primary essential hypertension patients

Kędziora–Kornatowska, Kornelia; Szewczyk-Golec, Karolina; Czuczejko, Jolanta; Pawluk, Hanna; Lumen, Katarzyna van Marke de; Kozakiewicz, Mariusz; Bartosz, Grzegorz; Kędziora, J

doi:10.1111/j.1600-079x.2008.00592.x

Cited by 49 publications

(37 citation statements)

References 56 publications

(79 reference statements)

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“…Melatonin consumption (5 mg/ day for 30 days) in type 2 diabetic patients resulted in a significant rise in SOD-1 activity and a reduction in the MDA level [31]. Moreover, 5 mg/day melatonin supplementation for 30 days in primary essential hypertension patients significantly increased SOD-1 and catalase activity and reduced products of lipid peroxidation [34]. A very large body of evidences indicates that melatonin is a major scavenger of both oxygen-and nitrogenbased reactive molecules [15,35].…”

Section: Discussionmentioning

confidence: 96%

A Double-Blind, Placebo-Controlled Trial Related to the Effects of Melatonin on Oxidative Stress and Inflammatory Parameters of Obese Women

et al. 2014

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Section: Discussionmentioning

confidence: 96%

A Double-Blind, Placebo-Controlled Trial Related to the Effects of Melatonin on Oxidative Stress and Inflammatory Parameters of Obese Women

et al. 2014

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“…Beneficial antioxidant effects of melatonin have been recently shown in clinical settings for several chronic diseases, including patients with rheumatoid arthritis 52 , elderly patients with primary essential hypertension 53 , and females with infertility 54 . Melatonin has been administered in both physiological and pharmacological amounts to humans and animals, and there is widespread agreement that it is a non-toxic molecule 55 .…”

Section: Discussionmentioning

confidence: 99%

Melatonin attenuates methotrexate‐induced oxidative stress and renal damage in rats

Abraham

Kolli

Rabi³

2010

Cell Biochemistry & Function

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Nephrotoxicity is an adverse side effect of methotrexate (MTX) chemotherapy. The present study verifies whether melatonin, an endogenous antioxidant prevents MTX-induced renal damage. Adult rats were administered 7 mg/kg body weight MTX intraperitoneally for 3 days. In the melatonin pretreated rats, 40 mg/ kg body weight melatonin was administered daily intraperitoneally 1 h before the administration of MTX. The rats were killed 12 h after the final dose of MTX/vehicle. The kidneys were used for light microscopic and biochemical studies. The markers of oxidative stress were measured along with the activities of the antioxidant enzymes and myeloperoxidase activity in the kidney homogenates. Pretreatment with melatonin reduced MTX induced renal damage both histologically and biochemically as revealed by normal plasma creatinine levels. Melatonin pretreatment reduced MTX induced oxidative stress, alteration in the activity of antioxidant enzymes as well as elevation in myeloperoxidase activity. The results suggest that melatonin has the potential to reduce MTX induced oxidative stress, neutrophil infiltration as well as renal damage. As melatonin is an endogenous antioxidant and is non-toxic even in high doses it is suggested that melatonin may be beneficial in minimizing MTX induced renal damage in humans.

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“…In these in vivo studies, melatonin was more effective than vitamin E (66-68), β-carotene (69), and vitamin C (69-71), and superior to garlic oil (72). Beneficial antioxidant effects of melatonin have been recently shown in clinical settings for several chronic diseases, including patients with rheumatoid arthritis (73), elderly patients with primary essential hypertension (74), and females with infertility (75). Several antioxidants reportedly preserve the activities of SOD and/or GSH-Px.…”

Section: Melatonin: a Versatile Antioxidantmentioning

confidence: 99%

Melatonin: An Established Antioxidant Worthy of Use in Clinical Trials

Korkmaz

Reíter

Topal

et al. 2009

Mol Med

258

181

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Oxidative stress plays a key role in the pathogenesis of aging and many metabolic diseases; therefore, an effective antioxidant therapy would be of great importance in these circumstances. Nutritional, environmental, and chemical factors can induce the overproduction of the superoxide anion radical in both the cytosol and mitochondria. This is the first and key event that leads to the activation of pathways involved in the development of several metabolic diseases that are related to oxidative stress. As oxidation of essential molecules continues, it turns to nitrooxidative stress because of the involvement of nitric oxide in pathogenic processes. Once peroxynitrite forms, it damages via two distinctive mechanisms. First, it has direct toxic effects leading to lipid peroxidation, protein oxidation, and DNA damage. This mechanism involves the induction of several transcription factors leading to cytokine-induced chronic inflammation. Classic antioxidants, including vitamins A, C, and E, have often failed to exhibit beneficial effects in metabolic diseases and aging. Melatonin is a multifunctional indolamine that counteracts virtually all pathophysiologic steps and displays significant beneficial actions against peroxynitrite-induced cellular toxicity. This protection is related to melatonin′s antioxidative and antiinflammatory properties. Melatonin has the capability of scavenging both oxygen-and nitrogenbased reactants, including those formed from peroxynitrite, and blocking transcriptional factors, which induce proinflammatory cytokines. Accumulating evidence suggests that this nontoxic indolamine may be useful either as a sole treatment or in conjunction with other treatments for inhibiting the biohazardous actions of nitrooxidative stress.

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Antioxidative effects of melatonin administration in elderly primary essential hypertension patients

Cited by 49 publications

References 56 publications

A Double-Blind, Placebo-Controlled Trial Related to the Effects of Melatonin on Oxidative Stress and Inflammatory Parameters of Obese Women

A Double-Blind, Placebo-Controlled Trial Related to the Effects of Melatonin on Oxidative Stress and Inflammatory Parameters of Obese Women

Melatonin attenuates methotrexate‐induced oxidative stress and renal damage in rats

Melatonin: An Established Antioxidant Worthy of Use in Clinical Trials

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