Antioxidative effects of hesperetin against lead acetate-induced oxidative stress in rats

Wang, Jicang; Zhu, Huanfeng; Zhou, Yang; Liu, Zongping

doi:10.4103/0253-7613.115015

Cited by 90 publications

(54 citation statements)

References 20 publications

(26 reference statements)

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“…Exposure to lead may alter antioxidant defense mechanism, which results in an imbalance Groups between radical-generating and radical-scavenging activities, and consequently, the formation of oxidation products. The finding of elevation in MDA concentration in lead exposed animals is consistent with the result obtained in previous studies (Aksu et al, 2012;Nisar et al, 2013;Wang et al, 2013;Okediran et al, 2017), verifying that exposure to lead causes an increase in MDA concentration. The significant increase in MDA concentration produced by exposure to lead suggests an increase in lipid peroxidation, which is an indicator to increased levels of free radicals in the serum and tissues of lead exposed rats.…”

Section: Discussionsupporting

confidence: 92%

Lead-induced increase in erythrocyte osmotic fragility and malondialdehyde concentration in Wistar rats: Chemo-protective effects of flavonoid mixture

Yusuf¹,

Akefe²,

Mohammed³

et al. 2018

Biochem Biotechnol Res

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Lead has been affirmed as a potent toxicant impairing physiological functions and causing innumerable perturbations at cellular and tissue levels. Daflon ® 500 mg is a flavonoid fraction of Rutaceae aurantiae comprising 90% diosmin and 10% hesperidin. The aim of this study was to evaluate the effect of flavonoid mixture against cellular injury caused by lead-induced generation of free radicals. Forty adult male Wistar rats divided into five groups of eight animals each were used for the experiment. Group I was administered distilled water only. Group II: lead (250 mg/kg BW), group III: lead (250 mg/kg BW) followed by dimercaptosuccinic acid (DMSA) (10 mg/kg BW), group IV: lead (250 mg/kg BW) followed by Daflon ® (100 mg/kg BW) and group V: lead (250 mg/kg BW) followed by Daflon ® (100 mg/kg BW) and DMSA (10 mg/kg BW). The xenobiotics were all administered orally. At the end of four weeks, EDTA-blood samples and serum samples were collected from the rats, and were used to evaluate changes in erythrocyte osmotic fragility and lipid peroxidation, respectively. Experimental exposure of rats to lead caused an increase in erythrocyte osmotic fragility (EOF) and lipid peroxidative changes, while administration of Daflon ® ameliorated the ensued damages. In conclusion, is plausible that the flavonoid mixture alleviated the detrimental effects of lead toxicity via its membrane stabilization, cytoprotective and osmoregulatory potentials.

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Section: Discussionsupporting

confidence: 92%

Lead-induced increase in erythrocyte osmotic fragility and malondialdehyde concentration in Wistar rats: Chemo-protective effects of flavonoid mixture

Yusuf¹,

Akefe²,

Mohammed³

et al. 2018

Biochem Biotechnol Res

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“…Also, it can protect the cells from damage induced by I/R 74 . It has reported that HES treatment increased SOD, CAT and GSH-Px activities and reduced the tissue damage caused by oxidative stress-induced ischemia and I/R 75 . It was suggested that HES has positive effects on SOD, CAT and GSH-Px activities and has protective effects against oxidative stress in rat brain 76 .…”

Section: Resultsmentioning

confidence: 99%

A comparative study on the antioxidant effects of hesperidin and ellagic acid against skeletal muscle ischemia/reperfusion injury

Akdemir

Gülçın

Karagöz

et al. 2016

Journal of Enzyme Inhibition and Medicinal Chemistry

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The antioxidant effects of ellagic acid (EA) and hesperidin (HES) against skeletal muscle ischemia/reperfusion injury (I/R) were performed. Hindlimb ischemia has been induced by tourniquet occlusion for 2 h on left hindlimb. At the end of ischemia, the tourniquate has been removed and initiated reperfusion for 2 h. EA (100 mg/kg) has been applied orally before ischemia/reperfusion in the EA + I/R group. HES (100 mg/kg) has been given orally in the HES + I/R group. The left gastrocnemius muscle has been harvested and stored immediately at À80 C until assessed for the levels of MDA and antioxidant enzymes activities. MDA level has statistically increased in I/R group (p50.05) compared to other groups. The muscle tissue antioxidant enzymes activities were lower than the other groups in the I/R group (p50.05). EA and HES treatments significantly reversed the damage level in I/R, also activity of tissue SOD increased in the EA + I/R and HES + I/R groups.

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“…Therefore, BV aqueous extract could mitigate oxidative stress by increasing GSH level through scavenging H 2 O 2 as it was demonstrated by Gurer and Ercal [4] . BV polyphenols might be the potential agents in the chelating processes [40][41] .…”

Section: Resultsmentioning

confidence: 99%

Nephroprotective Effects of Berberis Vulgaris L. Total Extract on Lead Acetate-induced Toxicity in Mice

Laamech¹,

El-Hilaly²,

Fetoui³

et al. 2016

pharmaceutical-sciences

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Laamech, et al.: Berberis vulgaris Effect on Lead Nephrotoxicity in MiceThis study aimed to investigate the potential effects of Berberis vulgaris L. against lead acetate-induced nephrotoxicity in Swiss albino mice. Mice were exposed chronically to lead acetate, at a dose of 5 mg/kg, alone or in conjunction with B. vulgaris extract (25, 50, 100 and 150 mg/kg). Lead acetate administration increased lead burden in blood and kidneys, altered renal biomarkers (serum creatinine, urea and uric acid), increased malondialdehyde and protein carbonyls levels, and decreased reduced glutathione, glutathione peroxidase, catalase, and superoxide dismutase. Histological studies showed glomerular degeneration and hypercellularity. However, B. vulgaris extract co-treatment significantly and dose-dependently restored the renal parameters, antioxidant enzymes, and histopathological changes near to the normal status, mainly via its antioxidant properties and/or by preventing lead bioaccumulation. Therefore, B. vulgaris extract showed nephroprotective effects against lead-induced nephrotoxicity mainly through its antioxidant and metal chelating properties.

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Antioxidative effects of hesperetin against lead acetate-induced oxidative stress in rats

Cited by 90 publications

References 20 publications

Lead-induced increase in erythrocyte osmotic fragility and malondialdehyde concentration in Wistar rats: Chemo-protective effects of flavonoid mixture

Lead-induced increase in erythrocyte osmotic fragility and malondialdehyde concentration in Wistar rats: Chemo-protective effects of flavonoid mixture

A comparative study on the antioxidant effects of hesperidin and ellagic acid against skeletal muscle ischemia/reperfusion injury

Nephroprotective Effects of Berberis Vulgaris L. Total Extract on Lead Acetate-induced Toxicity in Mice

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