Antioxidative Effects of Exercise Training in Patients With Chronic Heart Failure

Linke, Axel; Adams, Volker; Schulze, P. Christian; Erbs, Sandra; Gielen, Stephan; Fiehn, Eduard; Möbius‐Winkler, Sven; Schubert, Andreas; Schuler, Gerhard; Hambrecht, Rainer

doi:10.1161/01.cir.0000165503.08661.e5

Cited by 278 publications

(274 citation statements)

References 37 publications

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“…Similar results have been reported regarding the effect of regular exercise training, for example 12 weeks of moderate intensity aerobic exercise performed 3 days a week on antioxidant defence mechanisms resulted in an up-regulation in antioxidant enzymes, evident by an increase in the activity of superoxide dismutase, GPx and catalase [19].…”

Section: Discussionsupporting

confidence: 86%

Efficacy of selected treadmill training programme on oxidative stress in adolescents with Down syndrome

Meguid¹,

Eltohamy

Anwar³

et al. 2013

East Mediterr Health J

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The aim of this study was to assess the efficacy of an electronic treadmill exercise training programme on malondialdehyde (MDA) as a marker for lipid peroxidation and the antioxidant enzyme glutathione peroxidase (GPx) in adolescents with Down syndrome. The study was carried out on 30 adolescent males with Down syndrome, ranging in age from 15 to 18 years, with 30 healthy subjects as a control group. Clinical examination, anthropometric measurements and determination of GPx activity and MDA before and after exercise were done. A treadmill training programme was performed for 12 weeks. Our data showed a significant increase in GPx activity and decrease in serum level of MDA in Down syndrome individuals after treadmill exercise for 3 months. Exercise promotion for adolescents with Down syndrome requires attention to motivators and facilitators of exercise adherence as it may limit risk of increased neurological consequences associated with oxidative stress and improve quality of life. ‫داون‬ ‫بمتالزمة‬ ‫املصابني‬ ‫املراهقني‬ ‫يف‬ ‫التأكسدى‬ ‫اإلجهاد‬ ‫عىل‬ ‫الكهربائية‬ ‫املشاية‬ ‫بجهاز‬ ‫خمتار‬ ‫تدريبى‬ ‫برنامج‬ ‫إستخدام‬ ‫فعالية‬

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Section: Discussionsupporting

confidence: 86%

Efficacy of selected treadmill training programme on oxidative stress in adolescents with Down syndrome

Meguid¹,

Eltohamy

Anwar³

et al. 2013

East Mediterr Health J

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“…It has been reported that ET in CR improved NO production by increasing phosphorylation of endothelial NO synthase 22) and suppressed oxidative stress by increasing radical scavenger enzyme activity. 23) Taken together, the results suggest that supervised ET protects glomerular endothelial cells by improvement in the balance between NO bioavailability and oxidative stress, leading to a decrease in urinary albumin excretion. eGFR: In the current study, eGFR remained unchanged in the supervised group, whereas it deteriorated in the non-supervised group.…”

Section: Discussionmentioning

confidence: 82%

Impact of Supervised Cardiac Rehabilitation on Urinary Albumin Excretion in Patients With Cardiovascular Disease

et al. 2015

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SummaryUrinary albumin excretion is a predictor of cardiovascular death. Cardiac rehabilitation (CR) with exercise training (ET) has been shown to improve exercise capacity and prognosis in patients with cardiovascular disease (CVD). However, it remains unclear whether CR reduces urinary albumin excretion in CVD patients. We performed a retrospective, observational study using data obtained from 98 male CVD patients without macroalbuminuria and estimated glomerular filtration rate (eGFR) < 30 mL/minute/1.73 m 2 who participated in CR with ET during hospitalization. Twenty-three patients continued supervised ET for 6 months (supervised group) and 75 patients quit supervised ET (non-supervised group). The supervised ET program consisted of 60 minutes of supervised sessions 1-3 times a week and 30-60 minutes of home exercise at least twice a week. Urinary albumin/creatinine ratio (ACR) was significantly decreased in the supervised group at 6 months after enrollment (43 ± 71 mg/g to 17 ± 20 mg/g creatinine, P < 0.05) but not in the non-supervised group. eGFR was unchanged in the supervised group but was significantly decreased in the non-supervised group (72 ± 18 mL/minute/1.73 m 2 to 67 ± 17 mL/minute/1.73 m 2 , P < 0.001). The results of multiple regression analysis showed that only supervised ET was an independent contributor to ΔACR. CR with supervised ET decreased urinary albumin excretion without deterioration of renal function. These findings suggest that continuation of a supervised ET program is associated with reduction in the development of CVD and reduction in cardiovascular morbidity and mortality in CVD patients. (Int Heart J 2015; 56: 105-109) Key words: Supervised exercise training U rinary albumin excretion has long been recognized as a risk factor for progression to end-stage renal failure in individuals in the general population as well as individuals with hypertension or diabetes mellitus. Recently, urinary albumin excretion has been shown to be associated with an increased incidence of all-cause and cardiovascular morbidity and mortality in general populations and in patients with hypertension or diabetes mellitus. [1][2][3] In addition, low levels of urinary albumin excretion well below the current microalbuminuria threshold have been shown to predict the development of CVD. 4,5) CR with ET has been shown to improve exercise capacity and prognosis in CVD patients.6) Medications such as angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), and statins have also been reported to improve prognosis in CVD patients. In addition, these medications reduce urinary albumin excretion.7-9) However, it remains unclear whether CR ameliorates albuminuria in patients with CVD.The purpose of the present study was to clarify the effect of CR on urinary albumin excretion in patients with CVD.

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“…Axel Linke et al 47 Avaliação da atividade enzimática da Catalase, Superóxido Dismutase e Glutationa Peroxidase no músculo esquelético através de biópsia.…”

Section: Autorunclassified

Insuficiência cardíaca e atividade física: o aumento de enzimas antioxidantes e a melhora da atividade nervosa simpática

Gonçalves

Valenti

Ferreira

et al. 2010

Arq. Bras. Ciên. Saúde

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ResumoA insuficiência cardíaca vem se tornando um problema cada vez maior em saúde pública, e uma das principais causas de internações hospitalares em todo o mundo.Mesmo com os progressos médicos e os avanços tecnológicos atuais, a prevalência da doença aumentou nas últimas cinco décadas. Estudos recentes com animais mostraram que existe uma relação entre hiperatividade simpática na insuficiência cardíaca e aumento do estresse oxidativo sistêmico e central. Este trabalho tem como objetivo analisar, por meio de revisão bibliográfica, os benefícios produzidos pela atividade física em pacientes portadores de insuficiência cardíaca. Foram revisados estudos relacionados ao estresse oxidativo, controle neural da circulação, insuficiência cardíaca e exercício físico entre outubro de 2009 e abril de 2010 nas bases de dados: Medline, Pubmed e Lilacs. As referências eram datadas de 1986 a 2010. Utilizaram-se os seguintes termos: "Oxidative Stress", "Chronic Heart Failure", "Baroreflex", "Nervous System" and "Exercise". Ratos com insuficiência cardíaca induzida possuem um aumento de espécies reativas de oxigênio na região rostroventrolateral do bulbo, assim como comprometimento na atividade simpática. Alguns estudos sugerem que a atividade física normaliza a atividade simpática por meio de seus mecanismos antioxidantes em seres humanos. Outro aspecto interessante é que a atividade física reduz os níveis plasmáticos de angiotensina II, regula a disfunção do baroreflexo arterial e promove o aumento de enzimas antioxidantes no músculo esquelético de pacientes com insuficiência cardíaca. Portanto, conclui-se que a atividade física é um regime terapêutico não-farmacológico de extrema importância para pacientes com insuficiência cardíaca.Palavras-chave: Insuficiência cardíaca; estresse oxidativo; exercício físico; sistema neural. AbstractHeart failure is an increasing problem in public health, and a major cause of hospitalization worldwide. Even with the medical progress and technological advances in the present, the prevalence of the disease increased in the last five decades. Recent animal studies have shown that there is a relationship between sympathetic hyperactivity in heart failure and increased oxidative stress, systemic and central. This paper aims to examine, through literature review, the benefits of physical activity in patients with heart failure. We reviewed studies related to oxidative stress, neural control of circulation, heart failure and exercise between October 2009 and April 2010, on the databases: Medline, Pubmed e Lilacs. The references dated from 1986 to 2010, and we used the following terms: "oxidative stress", "chronic heart failure", "baroreflex", "nervous system" and "exercise". Rats with induced heart failure have an increase of reactive oxygen species in the rostroventrolateral medula, and impairment of sympathetic activity. Some studies suggest that physical activity normalizes the sympathetic activity through its antioxidant mechanisms in the rostroventrolateral medulla. Some studies suggest that ...

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Antioxidative Effects of Exercise Training in Patients With Chronic Heart Failure

Cited by 278 publications

References 37 publications

Efficacy of selected treadmill training programme on oxidative stress in adolescents with Down syndrome

Efficacy of selected treadmill training programme on oxidative stress in adolescents with Down syndrome

Impact of Supervised Cardiac Rehabilitation on Urinary Albumin Excretion in Patients With Cardiovascular Disease

Insuficiência cardíaca e atividade física: o aumento de enzimas antioxidantes e a melhora da atividade nervosa simpática

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