Antioxidative effects and percutaneous absorption of five polyphenols

Alonso, Cristina; Rubió, Laura; Touriño, Sonia; Martı́, Meritxell; Barba, Clara; Fernández-Campos, Francisco; Coderch, L.; Parra, J. L.

doi:10.1016/j.freeradbiomed.2014.07.014

Cited by 44 publications

(42 citation statements)

References 36 publications

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“…Resveratrol dimers belong to a group of compounds called stilbenes, which along with proanthocyanidins, anthocyanins, catechins, and flavonols are natural phenolic compounds found in grapes and red wine. Stilbenes have a variety of structural isomers, all of which exhibit various biological properties, such as antioxidative properties , platelet aggregation inhibition , antimicrobial , and antiaging activities . Thus, effective preparative separation of bioactive isomer of resveratrol dimers from wine grapes is of great importance.…”

Section: Introductionmentioning

confidence: 99%

Isolation and purification of two antioxidant isomers of resveratrol dimer from the wine grape by counter‐current chromatography

Kong

Yin

et al. 2016

J of Separation Science

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Resveratrol dimers belong to a group of compounds called stilbenes, which along with proanthocyanidins, anthocyanins, catechins, and flavonols are natural phenolic compounds found in grapes and red wine. Stilbenes have a variety of structural isomers, all of which exhibit various biological properties. Counter-current chromatography with a two-phase solvent system composed of n-hexane/ethyl acetate/methanol/water (2:5:4:5, v/v/v/v) was applied to isolate and purify stilbene from the stems of wine grape. Two isomers of resveratrol dimers trans-ε-viniferin and trans-δ-viniferin were obtained from the crude sample in a one-step separation, with purities of 93.2 and 97.5%, respectively, as determined by high-performance liquid chromatography. The structures of these two compounds were identified by (1) H and (13) C NMR spectroscopy. In addition, their antioxidant activities were assessed by 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. The antioxidant activities of trans-δ-viniferin were higher than that of trans-ε-viniferin in this model. This work demonstrated that counter-current chromatography is a powerful and effective method for the isolation and purification of polyphenols from wine grape. Additionally, the DPPH radical assay showed that the isolated component trans-δ-viniferin exhibited stronger antioxidant activities than trans-ε-viniferin and a little bit weaker than vitamin E at the same concentration.

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Section: Introductionmentioning

confidence: 99%

Isolation and purification of two antioxidant isomers of resveratrol dimer from the wine grape by counter‐current chromatography

Kong

Yin

et al. 2016

J of Separation Science

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“…Clinical use of RSV as a depigmenting agent has been limited yet, but topical resveratryl triacetate—a prodrug of RSV—and resveratryl triglycolate—a hybrid compound of RSV and glycolic acid—were shown to exhibit a significant reduction in UV‐induced pigmentation . Topically applied 4nBR or RSV was reported to penetrate into the skin …”

Section: Discussionmentioning

confidence: 99%

“…9,10 Topically applied 4nBR or RSV was reported to penetrate into the skin. 19,20 We previously demonstrated that combination of 4nBR and RSV at a low dose synergistically reduced melanin synthesis in vitro. 11 Though 1μM of 4nBR and 1μM of RSV did not individually inhibit melanin synthesis, the combination of 4nBR and RSV at the same concentration significantly reduced melanin synthesis by lowering tyrosinase levels.…”

Section: Rsv Inhibits Melanogenesis Through Various Mechanisms Rsvmentioning

confidence: 99%

Efficacy of liposome‐encapsulated 4‐n‐butylresorcinol and resveratrol cream in the treatment of melasma

Kwon

Yang

Shin

et al. 2019

J of Cosmetic Dermatology

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Backgrounds We previously reported the efficacy of 0.1% 4‐n‐butylresorcinol (4nBR) cream in the treatment melasma and synergistic effect of 4nBR and resveratrol (RSV) to inhibit melanogenesis in vitro. Aims To evaluate efficacy and safety of a cream which contains liposome‐encapsulated 4nBR and RSV in the treatment of melasma. Patients/Methods A total of 21 female patients with melasma were treated with the cream for 4 weeks. At baseline, week 2, and week 4, melanin index (MI) of the lesional and preauricular nonlesional skin was measured and two blinded, independent dermatologists assessed the overall severity by 5‐point scale. Results The lesional MI was significantly decreased at weeks 2 and 4 compared with the baseline while no significant change in the nonlesional MI was observed throughout the study. The mean investigator's global assessment score was also significantly improved at weeks 2 and 4. In patient's self‐assessment, 8 (38.1%) and 11 (52.3%) patients answered moderate to significant improvement in their melasma at weeks 2 and 4, respectively. No serious adverse events were reported. Conclusion The cream containing liposome‐encapsulated 4nBR and RSV was shown to be effective and safe for the treatment of melasma with its effect appearing as early as 2 weeks.

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“…Previous EPR spectroscopy studies suggested that hydrophilic substances such as vitamin C will increase the antioxidant potential of the skin after 2 weeks of supplementation [61], while carotenoids as hydrophobic substances exert their effects fully only after 8 weeks [62]. Green tea polyphenols are intermediate in their hydrophobicity [71], with several components, including quercetin and epicatechin, considered to be rather lipophilic [57,72]. Therefore, further studies with a longer follow-up should be performed to investigate the kinetics of the cutaneous radical scavenging effects of green tea.…”

Section: Discussionmentioning

confidence: 99%

A Randomized Controlled Trial of Green Tea Beverages on the in vivo Radical Scavenging Activity in Human Skin

Megow¹,

Darvin²,

Meinke³

et al. 2017

Skin Pharmacol Physiol

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Background: Oxidative stress plays an important role in the pathogenesis of various skin diseases. Thus, the antioxidant network of the skin relies on the uptake of exogenous antioxidants to ensure cell protection against radical formation. Green tea is one of the main sources of polyphenolic antioxidant compounds, but only few data are available on its cutaneous antioxidant effects. Methods: The radical scavenging properties of Benifuuki and Yabukita green tea were investigated in the human skin. Thirty-two participants who met the inclusion criteria were randomized to consume 3 cups per day of either Benifuuki tea, Yabukita tea, or water (control group) for 2 weeks. Electron paramagnetic resonance (EPR) spectroscopy was applied to measure the radical scavenging capacity of the skin in vivo before and after the intervention. Results: Both Yabukita and Benifuuki tea led to an increase in the radical scavenging activity of the skin by 28 and 29%, respectively, and the difference was significant when compared to the control group. Benifuuki tea, previously reported to be superior in bioavailability due to a highly absorbable methylated catechin, did not prove to be more effective than the common Yabukita tea. Conclusion: The results show that green tea enhances the radical scavenging capacity of the skin and support the hypothesis that green tea may offer protection against cutaneous oxidative stress.

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Antioxidative effects and percutaneous absorption of five polyphenols

Cited by 44 publications

References 36 publications

Isolation and purification of two antioxidant isomers of resveratrol dimer from the wine grape by counter‐current chromatography

Isolation and purification of two antioxidant isomers of resveratrol dimer from the wine grape by counter‐current chromatography

Efficacy of liposome‐encapsulated 4‐n‐butylresorcinol and resveratrol cream in the treatment of melasma

A Randomized Controlled Trial of Green Tea Beverages on the in vivo Radical Scavenging Activity in Human Skin

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