Antioxidative components of Psoralea corylifolia (Leguminosae)

Haraguchi, Hiroyuki; Inoue, Junji; Tamura, Yukiyoshi; Mizutani, Kenji

doi:10.1002/ptr.972

Cited by 144 publications

(79 citation statements)

References 43 publications

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“…This category of flavonoids displays a broad spectrum of bioactivities such as anticancer, antifungal, antibacterial, anti-inflammatory, analgesic, and antioxidative activities. [22][23][24] In a previous study, panduratin A showed significant anti-inflammatory activity, 12,13) however, antioxidative activity of panduratin A has not yet been examined. This study aimed to investigate the protective effects of panduratin A against oxidative stress and the mechanisms involved in the human hepatoma cell line, HepG2.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Panduratin A against Oxidative Damage of tert-Butylhydroperoxide in Human HepG2 Cells

Sohn

Han

Lee

et al. 2005

Biological & Pharmaceutical Bulletin

104

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Reactive oxygen species (ROS) act as subcellular messengers in such complex cellular processes as mitogenic signal transduction, gene expression, and regulation of cell proliferation.1) Excessive production of ROS may, however, cause oxidative stress, loss of cell function, and ultimately apoptosis or necrosis.2) Fortunately, cells possess antioxidant molecules which can neutralize ROS before they induce damage on vital components. However, oxidative stress occurs when antioxidant systems are overwhelmed by ROS. Oxidative stress is considered to play a prominent role in the causation of many diseases including aging, cardiovascular disease, cancer and liver injury. 3,4) tert-Butylhydroperoxide (t-BHP) is an organic hydroperoxidant that can be metabolized to free radical intermediates, which can subsequently initiate lipid peroxidation, affect cell integrity, and form covalent bonds with cellular molecules resulting in cell injury. 5) t-BHP causes leakage of lactate dehydrogenase (LDH) and formation of malondialdehyde (MDA) in hepatocytes, 6) and also mediates DNA base damage in mammalian cells. 7) These phenomena are similar to the oxidative stress occurring in the cell and/or tissue.Because of its unique metabolism and relationship to the gastrointestinal tract, the liver is an important target of the toxicity of drugs, xenobiotics, and oxidative stress. 8) Reactive oxygen species derived from chemicals or drugs exposed to liver cells seem to mediate liver injury, although the mechanisms of free radical toxicity are not well understood. 9)Therefore, primary importance is to understand the role of antioxidants which can reduce the oxidative stress induced by reactive intermediates from various chemicals and drugs. We have investigated hepatoprotective drugs, based on the measurement of cytotoxicity of t-BHP against human-liver-derived HepG2 cells. HepG2 cells have been suggested to be a useful in vitro model for investigation of the metabolism and toxicity of drugs compared with animal cells, since HepG2 cells retain many of the specialized functions which are characteristics of normal human hepatocytes, including the synthesis and secretion of plasma proteins. 10)Kaempferia pandurata ROXB. is a perennial herb of the family Zingiberaceae cultivated in some tropical countries, including Thailand and Indonesia. Its rhizome has been used as a food ingredient, an aphrodisiac, and a folk medicine for the treatment of colic disorder, fungal infections, dry cough, rheumatism, and muscular pains.11,12) Panduratin A (Fig. 1A) is a chalcone derivative isolated from K. pandurata. It was recently reported that panduratin A possessed significant topical anti-inflammatory activity in murine macrophages, 12) and in the TPA-induced ear edema in rats. 13)The objective of the current study was to examine the ability of panduratin A to protect hepatocytic injury induced by t-BHP and to characterize the mechanisms involved. For this purpose, we have studied the cell viability, lipid peroxidation, glutathione (GSH) level, and ROS le...

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Section: Discussionmentioning

confidence: 99%

Protective Effects of Panduratin A against Oxidative Damage of tert-Butylhydroperoxide in Human HepG2 Cells

Sohn

Han

Lee

et al. 2005

Biological & Pharmaceutical Bulletin

104

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“…This category of flavonoids has a broad bioactive spectrum such as anticancer, antibacterial, antifungal activities, etc. [10][11][12] In previous studies, chalcone compounds in K.…”

Section: )mentioning

confidence: 99%

“…This category of flavonoids has a broad bioactive spectrum such as anticancer, antibacterial, antifungal activities, etc. [10][11][12] In previous studies, chalcone compounds in K.pandurata showed anticancer, antioxidative, antimutagenic, and antibacterial activities. [13][14][15] However, their depigmenting effect has not yet been examined.…”

mentioning

confidence: 99%

Depigmentation of Melanocytes by Isopanduratin A and 4-Hydroxypanduratin A Isolated from Kaempferia pandurata ROXB.

Yoon

Shim

Cho

et al. 2007

Biological & Pharmaceutical Bulletin

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Melanin is the phenolic biopolymer that is responsible for pigmentation. Although melanin plays a crucial role in absorbing free radicals from the cytoplasm and shielding from UV light, the overproduction and accumulation of melanin in the skin could be a serious skin disorder. 1) Current therapies for skin pigmentation disease are unsatisfactory. Thus the search for natural and synthetic chemical agents to modulate the metabolism of pigmentation is of great interest. 2)Melanin biosynthesis occurs in a cascade of enzymatic and spontaneous reactions that convert tyrosine to melanin pigments.3) The initial and rate-limiting step in melanin synthesis, the hydroxylation of tyrosine to dihydroxyphenylalanine (DOPA), is controlled by tyrosinase that is the key enzyme in the process. 4) Since the 1980s, skin cancer researchers have studied the melanin biosynthetic pathways, which led to the development of whitening cosmetics and medicines.5) Arbutin, kojic acid, hydroquinone and its derivatives were developed in 1980s.6) However, the clinical effects of those chemicals are unsatisfactory because of their low activity and cell toxicity. 7) Therefore there is a need for safe and effective whitening agents.Kaempferia pandurata ROXB. is a perennial herb of the Zingiberaceae family mainly cultivated in tropical countries, including Indonesia and Thailand. The fresh rhizome has been used as a food ingredient and as a folk medicine for the treatment of colic, dry cough, rheumatism, musle pain, and as an aphrodisiac.8) Several studies reported various activities of K. pandurata, including antiinflammatory, antitumor, antidiarrhea, antidysentery, antiflatulence, and antiepidermophytid effects. 9) Isopanduratin A and 4-hydroxypanduratin A (Fig. 1) are the typical chalcone compounds found in K. pandurata. Chalcones belong to a group of phenolic compounds in the flavonoid family and widely occur in nature as pigments. This category of flavonoids has a broad bioactive spectrum such as anticancer, antibacterial, antifungal activities, etc. [10][11][12] In previous studies, chalcone compounds in K.pandurata showed anticancer, antioxidative, antimutagenic, and antibacterial activities. [13][14][15] However, their depigmenting effect has not yet been examined. Therefore we focused on evaluating the inhibitory effects of chalcone compounds isolated from K. pandurata on melanin biosynthesis and tyrosinase. Seocheon-dong, Giheung-gu, Yongin-si, Gyeonggi-do 446-701, South Korea: and c R&D Center, Amore-Pacific Corporation; 314-1, Bora-dong, Kiheung-gu, Yongin-si, Kyounggi-do 449-729, South Korea. Received April 11, 2007; accepted July 20, 2007 This study was carried out to investigate the in vitro effects of isopanduratin A and 4-hydroxypanduratin A isolated from Kaempferia pandurata ROXB. on melanin biosynthesis and tyrosinase activity. Two chalcone compounds, isopanduratin A and 4-hydroxypanduratin A, were isolated from the ethyl acetate fraction of ethanol extract as the active principles. Compared with phenylthiourea (IC 50 ‫3.4...

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“…[17][18][19] 2 has been reported to show an antiallergic effect, 20) and 3 has been reported to show antioxidative and antiplatelet activities. 17,21) Recently, 2 and 3 were found to inhibit the activity of acyl-CoA: cholesterol acyltransferase (ACAT), 22) but, their inhibitory activities against melanin biosynthesis have not been reported before. In recent reports, several prenylated flavonoids isolated from Artocapus heterophyllus were found to suppress melanin biosynthesis without inhibiting tyrosinase activity.…”

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confidence: 99%

Inhibitory Effects of Bakuchiol, Bavachin, and Isobavachalcone Isolated fromPiper longumon Melanin Production in B16 Mouse Melanoma Cells

Ohno

Watabe

Nakamura

et al. 2010

Bioscience, Biotechnology, and Biochemistry

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Antioxidative components of Psoralea corylifolia (Leguminosae)

Cited by 144 publications

References 43 publications

Protective Effects of Panduratin A against Oxidative Damage of <i>tert</i>-Butylhydroperoxide in Human HepG2 Cells

Protective Effects of Panduratin A against Oxidative Damage of <i>tert</i>-Butylhydroperoxide in Human HepG2 Cells

Depigmentation of Melanocytes by Isopanduratin A and 4-Hydroxypanduratin A Isolated from <i>Kaempferia pandurata</i> R<small>OXB</small>.

Inhibitory Effects of Bakuchiol, Bavachin, and Isobavachalcone Isolated fromPiper longumon Melanin Production in B16 Mouse Melanoma Cells

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