Antioxidative and therapeutic potential of selected Australian plants: A review

Mani, Janice S.; Johnson, Joel B.; Hosking, Holly; Ashwath, Nanjappa; Walsh, Kerry B.; Neilsen, Paul M.; Broszczak, Daniel; Naiker, Mani

doi:10.1016/j.jep.2020.113580

Cited by 50 publications

(37 citation statements)

References 53 publications

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“…In recent years, some anti-cancer active ingredients in Nar have become research targets in the food and medical fields (10,25). They can inhibit the growth of cancer cells via different molecular mechanisms, such as triggering cell cycle arrest, apoptosis, necrosis and autophagy (26). Studies have found that Nar initiates the release of TNF by inducing lipopolysaccharides, reduces the incidence of liver cancer, induces cancer cell apoptosis and inhibits oncogene expression through anti-oxidative and anti-free radical effects (27,28).…”

Section: Discussionmentioning

confidence: 99%

Naringin induces apoptosis of gastric carcinoma cells via blocking the PI3K/AKT pathway and activating pro‑death autophagy

Huang

et al. 2021

Mol Med Rep

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Section: Discussionmentioning

confidence: 99%

Naringin induces apoptosis of gastric carcinoma cells via blocking the PI3K/AKT pathway and activating pro‑death autophagy

Huang

et al. 2021

Mol Med Rep

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“…Terpenoids are non-saponifiable lipids or simple lipids found in many plants and mushrooms across the world. They are made up of differing numbers of linked isoprene units, and may be classified as monoterpenes, diterpenes, triterpenes, sesquiterpenes, etc., depending on the number of isoprene units present in the molecule [139][140][141][142]. Terpenoids are one of the largest classes of phytochemicals [143] that have shown to have anti-cancer effects against various cancers, including hepatocellular carcinoma [144,145].…”

Section: Terpenoidsmentioning

confidence: 99%

Phytochemicals as an Alternative or Integrative Option, in Conjunction with Conventional Treatments for Hepatocellular Carcinoma

Rodriguez

Skeet

Mehmetoglu-Gurbuz

et al. 2021

Cancers

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Hepatocellular carcinoma (HCC) is the most abundant form of liver cancer. It accounts for 75–85% of liver cancer cases and, though it ranks globally as the sixth most common cancer, it ranks second in cancer-related mortality. Deaths from HCC are usually due to metastatic spread of the cancer. Unfortunately, there are many challenges and limitations with the latest HCC therapies and medications, making it difficult for patients to receive life-prolonging care. As there is clearly a high demand for alternative therapy options for HCC, it is prudent to turn to plants for the solution, as their phytochemicals have long been used and revered for their many medicinal purposes. This review explores the promising phytochemical compounds identified from pre-clinical and clinical trials being used either independently or in conjunction with already existing cancer therapy treatments. The phytochemicals discussed in this review were classified into several categories: lipids, polyphenols, alkaloids, polysaccharides, whole extracts, and phytochemical combinations. Almost 80% of the compounds failed to progress into clinical studies due to lack of information regarding the toxicity to normal cells and bioavailability. Although large obstacles remain, phytochemicals can be used either as an alternative or integrative therapy in conjunction with existing HCC chemotherapies. In conclusion, phytochemicals have great potential as treatment options for hepatocellular carcinoma.

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“…The plant phytochemicals have been sub-classified into hydrobenzoic acids, hydroxycinnamic acids, stilbenes, lignans and flavonoids. This latter group has been subcategorized into flavonoids, flavones, isoflavones, flavanones, anthocyanidins and chalcones (Fig 2a) Australia is one of 17 megadiverse countries in the world and has a wealth of unique plant species [2].Although a systematic survey of Australian native plants for chalcone compounds has yet to be undertaken, the presence of chalcones in Australian native plants was noted in a recent review of the PubMed, SciFinder, Web of Knowledge, Scopus, and Science Direct databases for medicinal compounds in Australian plants and shrubs [67].…”

Section: Historical Perspectives On Australian Native Plantsmentioning

confidence: 99%

The Unique Australian Flora, A Veritable Pandora’s Pharmacopeia of Compounds with Therapeutic Biomedical Potential: Are the Chalcones the Geni in The Box?

Melrose¹

2021

GJSFR

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The aim of this review was to highlight the unique biodiversity of the flowering plants and shrubs of Australia and their component chemicals that evolved during the separation of the Australian continent from Gondwanaland. The chemicals produced by these flowering plants provided protection ensuring the survival of the Australian flora which had to contend with often harsh Australian climatic conditions. The diversity of plant phytochemicals produced by these flowering plants reflects the unique diversity of the Australian Flora and these represent a Pharmacological goldmine. It was beyond the scope of this review to cover the full spectrum of these chemical compounds present in Australian plants instead we focused on the chalcones in this review. This compound has a special status in medicinal chemistry as a base intermediate for the synthesis of a large repertoire of polycyclic compounds that display anti-bacterial, antifungal, anti-viral and anti-tumour properties and these are thus of considerable interest in Biomedicine.

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Antioxidative and therapeutic potential of selected Australian plants: A review

Cited by 50 publications

References 53 publications

Naringin induces apoptosis of gastric carcinoma cells via blocking the PI3K/AKT pathway and activating pro‑death autophagy

Naringin induces apoptosis of gastric carcinoma cells via blocking the PI3K/AKT pathway and activating pro‑death autophagy

Phytochemicals as an Alternative or Integrative Option, in Conjunction with Conventional Treatments for Hepatocellular Carcinoma

The Unique Australian Flora, A Veritable Pandora’s Pharmacopeia of Compounds with Therapeutic Biomedical Potential: Are the Chalcones the Geni in The Box?

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