Antioxidative activity of thiophane [bis(3-(3,5-di-tret-butyl-4-hydroxyphenyl)propyl)sulfide]

Ovchinnikova, L.P.; Rotskaya, Ulyana; Vasyunina, E. A.; Sinitsina, O. I.; Кандалинцева, Н. В.; Просенко, А. Е.; Nevinskii, G. A.

doi:10.1134/s1068162009030145

Cited by 9 publications

(4 citation statements)

References 27 publications

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“…Ascorbic acid was used as positive control. The antioxidant activity was determined as the percentage of inhibiting pyrogallol autoxidation, which was calculated from OD in the presence or absence of pyrogallol and samples 22–25.…”

Section: Methodsmentioning

confidence: 99%

Composition and antioxidant and antimicrobial activities of white apricot almond (Amygdalus communis L.) oil

Tian¹,

Zhang²,

Zhan³

et al. 2011

Euro J Lipid Sci & Tech

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In order to improve the level of comprehensive utilization and to promote the development of functional products, the chemical composition of white apricot almond oil was analyzed by capillary GC-MS and interpreted based on the standard mass spectral data, and biological activities were evaluated. Seven components of white apricot almond oil were identified. The scavenging capacity of white apricot almond oil in the superoxide anion radical system and hydroxyl radical system had a good performance. The IC 50 of white apricot almond oil to superoxide anion radical system and hydroxyl radical were 5.8 mg/mL and 0.17 mg/mL, respectively, and were stronger than that of ascorbic acid. In DPPH system, the IC 50 value of white apricot almond oil was 0.2 mg/mL and the IC 50 value of ascorbic acid was 0.07 mg/mL, but within the selected dosage, the highest scavenging capacity of white apricot almond oil was higher than that of ascorbic acid. White apricot almond oil was found to be a more effective antimicrobial agent than grape seed oil, fuji apple seed oil and mulberry seed oil. The minimum inhibitory concentration (MIC) of white apricot almond oil ranged from 0.2 to 0.4 mg/mL. The observed biological activities showed that the oil has a good potential for use in the food industry and pharmacy.

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Section: Methodsmentioning

confidence: 99%

Composition and antioxidant and antimicrobial activities of white apricot almond (Amygdalus communis L.) oil

Tian¹,

Zhang²,

Zhan³

et al. 2011

Euro J Lipid Sci & Tech

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“…The effect of PCP on OAT mutagenic activation by mouse hepatic enzymes was studied in vitro in Ames' test [9] using one of histidine-dependent Salmonella typhimurium tester strains -TA 98, carrying a histidine operon mutation. The bacterial cells were stored in liquid nitrogen (a frozen culture with 10% DMSO).…”

Section: Methodsmentioning

confidence: 99%

“…The bilayer agar technique was used in Ames' test system [9]. The lower layer contained 1.5% agar in the minimum M9 medium, containing 20% glucose and 50 mg/ml ampicillin.…”

Section: Methodsmentioning

confidence: 99%

Mutagenic Activation Reduces Carcinogenic Activity of Ortho-Aminoazotoluene for Mouse Liver

2013

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Pentachlorophenol (aromatic amine and azo stain metabolic stimulation inhibitor) reduced the hepatocarcinogenic activity of 4-aminoazobenzene and reduced that of ortho-aminoazotoluene in suckling mice. Both 4-aminoazobenzene and ortho-aminoazotoluene exhibited mutagenic activity in Ames' test in vitro on S. typhimurium TA 98 strain with activation with liver enzymes; this mutagenic activity was similarly suppressed by adding pentachlorophenol into activation medium. Induction of xenobiotic metabolism enzymes, stimulating the mutagenic activity of ortho-aminoazotoluene, suppressed its carcinogenic effect on mouse liver. Hence, ortho-aminotoluene (the initial compound), but not its mutagenic metabolites, was the direct active hepatocarcinogen for mice.

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“…The covalent S-C bonds are often used as a linker to construct polyfunctional molecules which possess diverse biological and pharmacological activity [ 30 ]. Sulfur-containing antioxidants attract particular attention [ 31 , 32 , 33 , 34 ]. The thiolated derivatives of phenols, tocopherols and ascorbic acid are polyfunctional compounds capable of antioxidant activity and other types of properties [ 35 , 36 , 37 , 38 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antioxidant Activity of New Catechol Thioethers with the Methylene Linker

et al. 2022

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Novel catechol thio-ethers with different heterocyclic substituents at sulfur atom were prepared by reacting 3,5-di-tert-butyl-6-methoxymethylcatechol with functionalized thiols under acidic conditions. A common feature of compounds is a methylene bridge between the catechol ring and thioether group. Two catechols with the thio-ether group, bound directly to the catechol ring, were also considered to assess the effect of the methylene linker on the antioxidant properties. The crystal structures of thio-ethers with benzo-thiazole moieties were established by single-crystal X-ray analysis. The radical scavenging and antioxidant activities were determined using 2,2′-diphenyl-1-picrylhydrazyl radical test, ABTS∙+, CUPRAC (TEAC) assays, the reaction with superoxide radical anion generated by xanthine oxidase (NBT assay), the oxidative damage of the DNA, and the process of lipid peroxidation of rat liver (Wistar) homogenates in vitro. Most catechol-thioethers exhibit the antioxidant effect, which varies from mild to moderate depending on the model system. The dual anti/prooxidant activity characterizes compounds with adamantyl or thio-phenol substituent at the sulfur atom. Catechol thio-ethers containing heterocyclic groups (thiazole, thiazoline, benzo-thiazole, benzo-xazole) can be considered effective antioxidants with cytoprotective properties. These compounds can protect molecules of DNA and lipids from the different radical species.

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Antioxidative activity of thiophane [bis(3-(3,5-di-tret-butyl-4-hydroxyphenyl)propyl)sulfide]

Cited by 9 publications

References 27 publications

Composition and antioxidant and antimicrobial activities of white apricot almond (Amygdalus communis L.) oil

Composition and antioxidant and antimicrobial activities of white apricot almond (Amygdalus communis L.) oil

Mutagenic Activation Reduces Carcinogenic Activity of Ortho-Aminoazotoluene for Mouse Liver

Synthesis and Antioxidant Activity of New Catechol Thioethers with the Methylene Linker

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