Antioxidative activity of sulfur‐containing compounds in Allium species for human LDL oxidation in vitro

Abstract

Sulfur-containing compounds contributing to health promotion in Allium species are produced via enzymic and thermochemical reactions. Sulfur-containing amino acids and volatile organosulfur compounds were prepared for an antioxidative assay. The inhibitory activity of S-alk(en)yl-L-cysteines and their sulfoxides, volatile alk(en)yl disulfides and trisulfides, and vinyldithiins in Allium species against lipid hydroperoxide (LOOH) formation in human low-density lipoprotein (LDL) was examined. It was elucidated that the alk(en)yl substituents (methyl, propyl, and allyl) and the number of sulfur atoms in the compounds were important for the antioxidative activity. 3,4-Dihydro-3-vinyl-1,2-dithiin, which is produced by a thermochemical reaction of allyl 2-propenethiosulfinate, exhibited the highest antioxidative activity of human LDL among sulfur-containing compounds.

Preventive effects of garlic (Allium sativum) on oxidative stress and histopathology of cardiac tissue in streptozotocin-induced diabetic rats

“…The antioxidant activity of Allium sativum could be attributed mainly to a variety of sulphur-containing compounds and their precursors (21). The primary sulfur-containing compound of intact garlic bulb is γ-glutamyl cysteine which can be hydrolyzed and oxidized to form alliin (2).…”

“…The primary sulfur-containing compound of intact garlic bulb is γ-glutamyl cysteine which can be hydrolyzed and oxidized to form alliin (2). Alliin is converted to odoriferous thiosulfinate allicin by alliinase after processing such as crushing, cutting, chewing or dehydration (21). Scientific evidence shows that allicin, diallyl disulphide and diallyl trisulphide appeared to be the main antioxidative compounds (15).…”

Effect of Allium sativum on the Carbohydrate Metabolism of Haemonchus contortus

“…Various researchers have reported that oil of A. sativum has possessed anthelmintic activity [22][23][24][25]. The pharmacological properties of garlic are strictly associated with presence of such chemical compounds as aromatic sulphur-based compounds, phenolic compound (phenolic acids, flavonoids), polysaccharide and protein [26,27]. In the present investigation effect of Allium sativum on the carbohydrate metabolism of H. contortus was studied.…”

Naturally Occurring Organic Sulfur Compounds: An Example of a Multitasking Class of Phytochemicals in Anti-Cancer Research

“…Other garlic-derived compounds, including lipophilic polysulfides and dithiins have also shown to act as antioxidants (Amagase et al, 2001), e.g. by preventing LOOH formation on human LDL (Nishimura et al, 2004). Nishimura et al identified 3,4-dihydro-3-vinyl-1,2-dithiin as the compound with the most efficient antioxidant activity on human LDL at physiological concentration (Nishimura et al, 2004).…”

“…by preventing LOOH formation on human LDL (Nishimura et al, 2004). Nishimura et al identified 3,4-dihydro-3-vinyl-1,2-dithiin as the compound with the most efficient antioxidant activity on human LDL at physiological concentration (Nishimura et al, 2004). Another strategy used by OSCs is the increase in the cellular antioxidant defense by upregulating/activating phase II detoxification enzymes (see Section 5.1.1) as well as alteration of the GSH redox cycle have been demonstrated in response to AGE and SAC (Geng, 1997).…”