Antioxidative activity of persimmon and grape seed extract: in vitro and in vivo

Ahn, Hyeyoung; Jeon, Tae Il; Lee, Joo Yong; Hwang, Seong Gu; Lim, Yoongho; Park, Dong Ki

doi:10.1016/s0271-5317(02)00429-3

Cited by 102 publications

(70 citation statements)

References 25 publications

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“…by bleomycin. Silica particles which are insoluble are accumulated in lung parenchyma is successively gulped by macrophages and additional injuries are results of internal reactions in these cells (Ahn et al, 2002). It has been reported that certain exogenous agents can initiate the development of pulmonary fibrosis through accretion of considerable amounts of ROS in animal models (Franklin et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Camellia Oleifera Abel. On Silica-Induced Pulmonary Fibrosis in Rats

Tian¹,

Liu²,

Yang³

et al. 2017

Afr J Tradit Complement Altern Med

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Background: Camellia oleifera Abel. belongs to the family Theaceae and genus Camellia. It is commonly cultivated in southern China. The seeds of C. oleifera have been reported to exhibit a diversity of pharmacological activities which include, but are not limited to, antioxidant, anti-cancer and antimicrobial. Pulmonary fibrosis is one of lethal causes of mortality across the globe and accretion of considerable amount of reactive oxygen species (ROS) in lungs have been implicated in the onset of this disease. Given the known antioxidant activity of C. oleifera seed extract (CSE), the present study was designed to evaluate the influence of CSE on the silica-induced pulmonary fibrosis rat models. Materials and Methods: Protective effect of CSE was determined in silica-induced pulmonary fibrosis rat models. Malondialdehyde (MDA), hydroxyproline (HP) and superoxide dismutase 2 (SOD-2) activity were determined by standard biochemical assays. Histopathological analysis was carried out by H and E staining. Phyto-constituents of CSE were identified by LC/MS analysis. Results: The results of this study indicated that CSE lowered the MDA and hydroxyproline content in silica-treated rats. Additionally, CSE also caused a significant increase in the expression of SOD-2 leading to scavenging of ROS. Hematoxylin and eosin (H and E) staining of lung tissue sections revealed that CSE maintained the integrity of parenchymatous cells of lungs and prevented the development of pulmonary fibrosis. To gain insights about the phytochemical constituents of CSE, LC/MS analysis was carried out and several antioxidant phenolics and flavonoids were tentatively identified. Conclusion: Taken together, we conclude that CSE prevents development of pulmonary fibrosis and the protective effect of CSE may be due to its ability to induce SOD-2 expression and due to the presence antioxidant phytoconstituents.

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Section: Discussionmentioning

confidence: 99%

Protective Effect of Camellia Oleifera Abel. On Silica-Induced Pulmonary Fibrosis in Rats

Tian¹,

Liu²,

Yang³

et al. 2017

Afr J Tradit Complement Altern Med

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“…15 found that total phenol content of koruk (American Rootstock) was 652.13 mg/L.Ahn et al 16 reported that total tannin in grape seed extract were 535.64 mg/100g.Baydar et al 17 reported that total phenolic content extracted by different solvent mixtures ranged from 627.98 to 667.87 mg GAE/g in grape seed extracts. In ethanol extracts of unripe grape juice samples, total flavonoid content was found to be the highest (0.14 mg RE/g).…”

Section: öNcül and Karabıyıklımentioning

confidence: 98%

“…However, in ethanol extracts of unripe grape powder were found to be the lowest (64.07%). When comes to the distilled water, the highest and the lowest values were determined to unripe grape powder (82.64%) and unripe grape juice samples (68.88%), respectively.Ahn et al 16 reported that DPPH (% inhibition) in grape seed extract were found as 86.98%. Table 2 presents antimicrobial activity against only one test microorganism, C. albicans of sample extracts.…”

Section: öNcül and Karabıyıklımentioning

confidence: 98%

Total Phenolic and Flavonoid Contents, Antioxidant and Antimicrobial Activities of Traditional Unripe Grape Products

Türkmen¹,

Şekeroğlu²

2017

IJPER

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Unripe grape products, unripe grape juice (or koruk juice), unripe grape powder and unripe grape piece are common condiments in Kilis traditional cousin. Besides their taste roles, their probable health benefits were also studied in this work. To evaluate total phenolic and flavonoid contents, antioxidant capacity and antimicrobial activity of unripe grape samples (juice, powder and piece) extracted by various solvents. Samples were extracted separately by ethanol and distilled water (10%). Concentrated samples were suspended in methanol to final concentration 100 mg/mL. Percentage yield in the extracts were observed to range from 4.19 to 17.76. While the total phenolic contents of ethanol and distilled water extracts were revealed to range from 505.682 to 758.523 and 424.432 to 603.409 mg GAE/g; total flavonoid contents of extracts were 0.073 to 0.147 and 0.041 to 0.055 mgRE/g, respectively. Antioxidant capacity of extracts was calculated between 64.07(ethanol) and 82.64 % (distilled water). Studied extracts showed antimicrobial activity against only one test microorganism, C. albicans. The highest antibacterial activity (8 mm) was observed in unripe grape piece distilled water extract.

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“…Seven kinds of grape-seed extracts C-I and Toc from the Mitsubishi Chemical Co. were used as positive controls, because their antioxidative effects on TBA values have been previously reported 15,16 . Rosemary extract A and the grape-seed extracts were dissolved in H 2 O 1-50 mg/mL , whereas rosemary extract B and Toc were dissolved in isopropanol 1-50 mg/mL .…”

Section: Rosemary Extracts and Tocopherolmentioning

confidence: 99%

Suitability of TBA Method for the Evaluation of the Oxidative Effect of Non-water-soluble and Water-soluble Rosemary Extracts

Wada¹,

Nagano²,

Kido³

et al. 2011

J. Oleo Sci.

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Antioxidative activity of persimmon and grape seed extract: in vitro and in vivo

Cited by 102 publications

References 25 publications

Protective Effect of Camellia Oleifera Abel. On Silica-Induced Pulmonary Fibrosis in Rats

Protective Effect of Camellia Oleifera Abel. On Silica-Induced Pulmonary Fibrosis in Rats

Total Phenolic and Flavonoid Contents, Antioxidant and Antimicrobial Activities of Traditional Unripe Grape Products

Suitability of TBA Method for the Evaluation of the Oxidative Effect of Non-water-soluble and Water-soluble Rosemary Extracts

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