Antioxidation of human low density lipoprotein by unconjugated and conjugated bilirubins

Wu, Tai-Wing; Fung, Kwok‐Pui; Wu, Jun; Yang, Chih-Chin; Weisel, Richard D.

doi:10.1016/0006-2952(95)02395-x

Cited by 190 publications

(131 citation statements)

References 13 publications

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“…Furthermore, the total bilirubin level was inversely correlated with metabolic syndrome (9). Recently, Erdogan et al (10) (2,13). Antioxidative agents are known to act against the formation of atheromatous lesions in animal models and in humans (14,15 …”

Section: Discussionmentioning

confidence: 99%

Relationship between Serum Bilirubin and Carotid Atherosclerosis in Hypertensive Patients

Yang

Chen

et al. 2009

Intern. Med.

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Section: Discussionmentioning

confidence: 99%

Relationship between Serum Bilirubin and Carotid Atherosclerosis in Hypertensive Patients

Yang

Chen

et al. 2009

Intern. Med.

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“…2 The antioxidative properties may be independent of whether bilirubin is unconjugated, conjugated, free, or albumin-bound. 3,4,6 Recent investigations proposed bilirubin to be an antiatherogenic endproduct in the heme-oxygenase-carbon monoxide signalling pathway. 9,34 -36 The cytoprotective properties of bilirubin may be explained by its inhibition of protein kinase C (PKC).…”

Section: Discussionmentioning

confidence: 99%

A genome scan for loci influencing anti-atherogenic serum bilirubin levels

et al. 2002

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Epidemiological studies have shown an association of decreased serum bilirubin levels with coronary artery disease. Two segregation analyses in large pedigrees have suggested a major gene responsible for high bilirubin levels occurring in about 12% of the population. Based on a recessive model from a previous segregation analysis, we performed a genome scan using 587 markers genotyped in 862 individuals from 48 Utah pedigrees to detect loci linked to high bilirubin levels. As a complementary approach, non-parametric linkage (NPL) analysis was performed. These two methods identified four regions showing evidence for linkage. The first region is on chromosome 2q34 -37 with multipoint LOD and NPL scores of 3.01 and 3.22, respectively, for marker D2S1363. This region contains a previously described gene, uridine diphosphate glycosyltransferase 1, which has been associated with high bilirubin levels. A polymorphism in the promoter of this gene was recently shown to be responsible for Gilbert syndrome which is associated with mild hyperbilirubinemia. The other regions were found on chromosomes 9q21, 10q25 -26, and 18q12 with maximum NPL scores of 2.39, 1.55, and 2.79, respectively. Furthermore, we investigated in these pedigrees the association between bilirubin levels and coronary artery disease. One-hundred and sixty-one male and 41 female subjects had already suffered a coronary artery disease event. Male patients showed significantly lower bilirubin concentrations than age-matched controls. This association, however, was not observed in females. These results provide evidence that loci influencing bilirubin variation exist on chromosomes 2q34 -37, 9q21, 10q25 -26, and 18q12 and confirms the association of low bilirubin levels with coronary artery disease in males.

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“…Bilirubin prevents the oxidation of low-density lipoprotein-cholesterol (LDL-C) [1][2][3] , reduces the risk of atherosclerosis and coronary heart disease (CHD) [4][5][6] , tion and impaired fibrinolysis [14][15][16] ; however, the relationship among serum bilirubin, inflammatory markers, and coronary endothelial function remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Bilirubin Concentration, Coronary Endothelial Function, and Inflammatory Stress in Overweight Patients

Yoshino

Hamasaki

Ishida

et al. 2011

JAT

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Antioxidation of human low density lipoprotein by unconjugated and conjugated bilirubins

Cited by 190 publications

References 13 publications

Relationship between Serum Bilirubin and Carotid Atherosclerosis in Hypertensive Patients

Relationship between Serum Bilirubin and Carotid Atherosclerosis in Hypertensive Patients

A genome scan for loci influencing anti-atherogenic serum bilirubin levels

Relationship Between Bilirubin Concentration, Coronary Endothelial Function, and Inflammatory Stress in Overweight Patients

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