Antioxidants Reduce Oxidative Stress in Claudicants

Wijnen, M.H.W.A.; Coolen, Saj Stefan; Vader, HL Huib; Reijenga, JC Jetse; Huf, FA Fred; Roumen, R.M.H.

doi:10.1006/jsre.2000.6078

Cited by 24 publications

(20 citation statements)

References 28 publications

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“…However, whether higher antioxidant intake is beneficial in promoting better physical performance and muscular strength is still controversial. Although findings of some studies have shown improvements (46,114,118), other studies do not support a beneficial effect of increased antioxidant intakes on physical performance (3,6,7,88). Nevertheless, it seems reasonable that an adequate antioxidant intake is needed to maintain healthy muscular activity (67).…”

Section: Antioxidant Supplementationmentioning

confidence: 87%

Oxidative Damage and Platelet Activation as New Predictors of Mobility Disability and Mortality in Elders

Cesari

Kritchevsky

Leeuwenburgh

et al. 2006

Antioxidants & Redox Signaling

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Mobility disability is an early phase of the disablement process in older adults, and represents a major risk factor for physical disability and mortality. Pathophysiological mechanisms responsible for the onset of mobility limitation are still largely unknown. Oxidative damage, responsible for the disruption of the equilibrium of biological systems by damaging major constituent molecules, might play an important role in the pathway leading to major health-related events. It has been suggested the existence of a vicious cycle involving oxidative damage, platelet activation, and inflammation as promoter of pathophysiological changes occurring with aging. This hypothesis is based on the following observations: (a) oxidative damage is associated with diseases and clinical conditions potentially leading to disability and mortality; (b) oxidative damage is associated with platelet activation, and a vicious cycle involving oxidative damage, platelet activation, and inflammation has been demonstrated in several metabolic disorders potentially leading to mobility disability; (c) the age-related physical decline may be associated to the oxidative damage due to the excess of free radicals; (d) antioxidant defense and behavioral factors (e.g., physical activity, dietary restriction, smoking cessation) play an important role in the reduction of oxidative damage levels and are associated with improved physical performance and muscle strength.

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Section: Antioxidant Supplementationmentioning

confidence: 87%

Oxidative Damage and Platelet Activation as New Predictors of Mobility Disability and Mortality in Elders

Cesari

Kritchevsky

Leeuwenburgh

et al. 2006

Antioxidants & Redox Signaling

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“…More recently, administration of 200 mg of vitamin E along with 500 mg of vitamin C for 4 weeks was shown to reduce exercise‐associated oxidative stress (Wijnen et al. ), as did an intravenous infusion of vitamin C at a dosage of 50 mg/min for 20 min (Silvestro et al. ).…”

Section: Management Of Oxidative Stressmentioning

confidence: 99%

Oxidative stress and antioxidant treatment in patients with peripheral artery disease

et al. 2018

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Peripheral artery disease is an atherosclerotic disease of arterial vessels that mostly affects arteries of lower extremities. Effort induced cycles of ischemia and reperfusion lead to increased reactive oxygen species production by mitochondria. Therefore, the pathophysiology of peripheral artery disease is a consequence of metabolic myopathy, and oxidative stress is the putative major operating mechanism behind the structural and metabolic changes that occur in muscle. In this review, we discuss the evidence for oxidative damage in peripheral artery disease and discuss management strategies related to antioxidant supplementation. We also highlight the major pathways governing oxidative stress in the disease and discuss their implications in disease progression. Potential therapeutic targets and diagnostic methods related to these mechanisms are explored, with an emphasis on the Nrf2 pathway.

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“…Clinically, this is referred to as exercise‐induced claudication, and there is increasing evidence to suggest that acutely, this condition increases oxidative damage in muscle. Several studies have shown evidence of increases in plasma markers of oxidative stress: plasma malondialdehyde levels (Hickman et al 1994; Silvestro et al 2002; Turton et al 2002) and both p ‐hydroxyantipyrine and o ‐hydroxyantipyrine (free radical products of antipyrine; Wijnen et al 2001). In addition, using an animal model, we have found that acute exercise‐induced claudication causes protein oxidation and lipid peroxidation in skeletal muscle, and a reduction in total glutathione levels (Judge & Dodd, 2003).…”

mentioning

confidence: 99%

Antioxidants attenuate oxidative damage in rat skeletal muscle during mild ischaemia

Judge

Selsby

Dodd

2008

Experimental Physiology

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We have previously shown oxidative stress and oedema, caused by both xanthine oxidasederived oxidants and infiltrating neutrophils, within skeletal muscle after contractile-induced claudication. The purpose of this study was to determine whether supplementation with antioxidant vitamins attenuates the oxidative stress, neutrophil infiltration and oedema associated with an acute bout of contractile-induced claudication. Rats received vehicle, vitamin C, vitamin E or vitamin C + E for 5 days prior to contractile-induced claudication. Force production was significantly reduced in the claudicant limbs of all groups compared with the control (sham) limb of control animals. Contractile-induced claudication caused a significant increase in protein oxidation, lipid peroxidation, neutrophil infiltration and oedema compared with sham muscles. Supplementation with vitamin C, E or C + E prevented the increases in each of these, and there were no differences between groups. These findings suggest that, in an animal model of exercise-induced claudication, neutrophil chemotaxis is caused by oxidizing species and that antioxidant supplementation can prevent oxidative damage, neutrophil infiltration and oedema following an acute bout of contractile-induced claudication.

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Antioxidants Reduce Oxidative Stress in Claudicants

Cited by 24 publications

References 28 publications

Oxidative Damage and Platelet Activation as New Predictors of Mobility Disability and Mortality in Elders

Oxidative Damage and Platelet Activation as New Predictors of Mobility Disability and Mortality in Elders

Oxidative stress and antioxidant treatment in patients with peripheral artery disease

Antioxidants attenuate oxidative damage in rat skeletal muscle during mild ischaemia

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