Antioxidants Protect Cell Damage from Free Radicals: A research study on Thyroid Hormones in Wistar Rats.

Peepre, Karan; Bhimte, Bhawna; Deshpandey, U.; Choudhary, Dr.P.S.

doi:10.9790/0853-13157579

Cited by 3 publications

(4 citation statements)

References 10 publications

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“…A study conducted by Peepre, Deshpande, and Choudhary ( 125 ) showed that Vitamins C, E, and turmeric are positive thyroxine modulators. Wistar rats were used in the experiment and were given Vitamin C, E, and turmeric.…”

Section: Treatment Of Htmentioning

confidence: 99%

“…Wistar rats were used in the experiment and were given Vitamin C, E, and turmeric. It was demonstrated that the application of antioxidants, i.e., Vitamin C, Vitamin E, and turmeric, greatly increased the circulating levels of T3 and T4, which could be caused by the direct participation of antioxidants on the thyroid gland or the activity of deiodinase enzyme ( 125 ).…”

Section: Treatment Of Htmentioning

confidence: 99%

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The interplay of oxidative stress and immune dysfunction in Hashimoto’s thyroiditis and polycystic ovary syndrome: a comprehensive review

Batóg,

Dołoto,

Bąk

et al. 2023

Front. Immunol.

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In recent years, there has been a significant increase in the concomitant incidence of Hashimoto’s thyroiditis (HT) and polycystic ovary syndrome (PCOS), both in terms of incidence, etiology, and clinical consequences. PCOS patients suffering from autoimmune thyroid diseases show insulin resistance, impaired glucose tolerance, weight gain, and metabolic and reproductive complications. Studies have shown that chronic stress and its consequence, i.e. oxidative stress, play an important role in the pathomechanism of both disorders. It has also been shown that long-term exposure to stress triggers biological mechanisms, in particular related to the regulation of the inflammatory cascade, which plays a key role in autoimmune diseases. The paper is a review of the literature on the role of chronic stress, oxidative stress, and immune processes in the pathogenesis of HT and PCOS. In addition, the review is a source of knowledge about the treatment of these diseases, and in particular the use of antioxidants in therapeutic management.

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Section: Treatment Of Htmentioning

confidence: 99%

Section: Treatment Of Htmentioning

confidence: 99%

The interplay of oxidative stress and immune dysfunction in Hashimoto’s thyroiditis and polycystic ovary syndrome: a comprehensive review

Batóg,

Dołoto,

Bąk

et al. 2023

Front. Immunol.

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“…Phytochemicals like b-carotene are crucial in fighting free radicals as they target various enzymes across multiple pathways (9). Also, the intake of other antioxidants such as vitamin C and vitamin E in rats showed that they can reduce oxidative stress (10,11). Alongside b-carotene, selenium is also an antioxidant that is associated with TH levels.…”

mentioning

confidence: 99%

Is beta-carotene consumption associated with thyroid hormone levels?

et al. 2023

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The thyroid hormones play a pivotal role in various physiological processes, including growth, metabolism regulation, and reproduction. While non-modifiable factors are known to impact thyroid function, such as genetics and age, nutritional factors are also important. Diets rich in selenium and iodine are conventionally acknowledged to be beneficial for the production and release of thyroid hormones. Recent studies have suggested a potential link between beta-carotene, a precursor to vitamin A (retinol), and thyroid function. Beta-carotene is known for its antioxidant properties and has been shown to play a role in the prevention of various clinical conditions such as cancer and cardiovascular and neurological diseases. However, its impact on thyroid function is still unclear. Some studies have suggested a positive association between beta-carotene levels and thyroid function, while others have found no significant effect. Conversely, the hormone produced by the thyroid gland, thyroxine, enhances the conversion of beta-carotene to retinol. Furthermore, vitamin A derivatives are being explored as potential therapeutic options for thyroid malignancies. In this review, we highlight the mechanisms through which beta-carotene/retinol and thyroid hormones interact and review the findings of clinical studies examining the association between beta-carotene consumption and thyroid hormone levels. Our review underscores the need for further research to clarify the relationship between beta-carotene and thyroid function.

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“…Among the enzymatic antioxidants, are glutathione reductase, glutathione peroxidase, catalase, superoxide dismutase, while the non-enzymatic antioxidants are glutathione, Vit.E, Vit.C, β-carotene and flavonoids [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Effect of Iron, Zinc, Vitamin E and Vitamin C Supplementation on Thyroid Hormones in Rats with Hypothyroidism

Rabeh¹,

El-Ghandour²

2016

IJNFS

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Abstract:The aim of the study was to investigate the effect of Iron, Zinc, Vitamin C (Vit.C) and Vitamin E (Vit.E) supplementation on thyroid hormones in rats with hypothyroidism. Thirty six rats were divided into two main groups, the first main group (6 rats) was fed on basal diet only. The second main group (30 rat) were injected with 10 mg/kg/day Propylthiouracil (PTU) to induce hypothyroidism, was divided into 5 subgroups: including control positive group that fed on basal diet, and the other subgroups were fed on basal diet supplemented with 40 mg ferric sulphate/kg diet, 200 mg zinc carbonate /kg diet, 250 mg α-tocohperol acetate/kg/B.W. and 250 mg ascorbic acid/kg/B.W. respectively. Blood samples were collected from each rat and were centrifuged to obtain serum. PTU exposed rats showed hypothyroidism with significant (P<0.05) decline in serum FT3 and FT4 levels together with significant (P<0.05) increase in serum TSH level. The supplementation with Iron, Zinc, Vit.E or Vit.C significantly (P<0.05) increased the level of thyroid hormones (FT4 and FT3) and glutathione peroxidase, moreover, the level of TSH was significantly (P<0.05) decreased, compared with control positive group, might be due to their antioxidant properties. Significant improvement in lipid profile as well as liver and kidney functions were observed. It could be suggested that Vitamin C, Vitamin E, Zinc and Iron could be used as a suitable supplementation therapy for hypothyroidism patients.

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Antioxidants Protect Cell Damage from Free Radicals: A research study on Thyroid Hormones in Wistar Rats.

Cited by 3 publications

References 10 publications

The interplay of oxidative stress and immune dysfunction in Hashimoto’s thyroiditis and polycystic ovary syndrome: a comprehensive review

The interplay of oxidative stress and immune dysfunction in Hashimoto’s thyroiditis and polycystic ovary syndrome: a comprehensive review

Is beta-carotene consumption associated with thyroid hormone levels?

Effect of Iron, Zinc, Vitamin E and Vitamin C Supplementation on Thyroid Hormones in Rats with Hypothyroidism

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