Antioxidants of Natural Products

Kim, Mee Ree

doi:10.3390/antiox10040612

Cited by 7 publications

(4 citation statements)

References 22 publications

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“…[27] In this study, the milk yield in SIF-treated mice showed an increasing trend in a foodintake-independent manner, which suggests the effect is associated to the improved antioxidant capacity and augmented utilization of nutrients induced by SIF. [28] Increased heat production in mammary gland development and lactogenesis triggers heat stress and is accompanied by the production of a large number of free radicals in order to maintain energy equilibrium. [29] A previously published study showed that SIF increased antioxidant capacity among postmenopausal females.…”

Section: Discussionmentioning

confidence: 99%

Soybean Isoflavones Ameliorates Lactation Performance in Postpartum Mice by Alleviating Oxidative Stress and Regulating Gut Microflora

Shao,

Yu,

Pang

et al. 2024

Molecular Nutrition Food Res

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Postpartum dysgalactiae syndrome (PPDS) is one of the key issues affecting breastfeeding, usually occurring as breast swelling, a low milk yield, and at length a stop of breast milk secretion. Therefore, there is a need to investigate the effectiveness of Traditional Chinese Medicine (TCM) diet therapy in treating or preventing PPDS. This study aims to analyze the effect of soybean isoflavone (SIF), a natural estrogen found in plants, on postpartum lactation performance in mice and to evaluate its potential as a treatment for PPDS. Adult female BALB/c mice at 8 weeks of age (25 ± 3 g) are randomly divided into four groups fed with different levels of SIF and a normal diet for 14 days. SIF (0, 50, 100, 200 mg kg‐1 BW) is provided via intra‐gastric route to the experimental mice. Using a high‐throughput sequencing of microbial diversity and mammary gland metabolites, it is found that SIF‐treated mice potentially show an improved milk performance via enhanced antioxidant capacity and altered gut microbiota. SIF from plant sources at a high dosage promotes the lactation in normal postpartum mice.

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Section: Discussionmentioning

confidence: 99%

Soybean Isoflavones Ameliorates Lactation Performance in Postpartum Mice by Alleviating Oxidative Stress and Regulating Gut Microflora

Shao,

Yu,

Pang

et al. 2024

Molecular Nutrition Food Res

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“…However, PTT cannot effectively relieve oxidative stress induced by ROS, which destroys cell proteins, membrane lipids, and nucleic acids, eventually leading to cell death and delayed wound healing . ROS-scavenging drugs exhibit enhanced therapeutic effects by relieving oxidative stress for wound healing; such drugs include nonsteroidal anti-inflammatory drugs, metabolic modulators, , natural antioxidants, and artificial nanozymes . Natural antioxidants with high activity and low toxicity have been used to eliminate endogenous ROS .…”

Section: Introductionmentioning

confidence: 99%

Dynamic Microenvironment-Adaptable Hydrogel with Photothermal Performance and ROS Scavenging for Management of Diabetic Ulcer

Jia,

Li,

Zheng

et al. 2023

ACS Appl. Mater. Interfaces

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Persistent bacterial infections and excessive oxidative stress prevent the healing of diabetic ulcers, leading to an increased disability rate. Current treatments fail to kill bacteria while simultaneously relieving oxidative stress. Herein, a dynamic microenvironment-adaptable hydrogel (BP@CAu) with photothermal performance and reactive oxygen species scavenging is presented for diabetic ulcer healing. This hydrogel prepared using a dynamic borate-ester could respond to acidity in the infection microenvironment for a controllable drug release. An excellent photothermal conversion effect was integrated in the hydrogel, which exhibited strong antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa. The hydrogel attenuated intracellular oxidative stress and inflammation and promoted cell migration. In a full-thickness skin defect model of diabetic rats, the BP@CAu hydrogel contributed to the fastest wound closure, with ideal reepithelialization, granulation tissue formation, and regeneration of blood vessels. Further mechanistic studies revealed that the hydrogel relieved oxidative stress and downregulated the expression of inflammatory cytokines, resulting in dramatic therapeutic effects on diabetic wounds. Therefore, this study provides a synergistic therapeutic strategy for efficient photothermal performance and reactive oxygen species scavenging in diabetic ulcers.

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“…In recent years, the research and development of antioxidants has become an important research topic worldwide. However, synthetic chemical antioxidants have some potential health hazards; therefore, the antioxidants prepared by the modification of natural products have attracted much attention [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antioxidant Activity of (E) ω-Formylcamphene-Based Thiazole Hydrazone Derivatives

Chang¹,

Ding²,

Zhong³

et al. 2023

Journal of Renewable Materials

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E) ω-formylcamphene was synthesized from α-pinene, the main component of turpentine, and then reacted with thiosemicarbazide to obtain (E) ω-formylcamphene thiosemicarbazide 3, which was reacted with 14 α-bromoacetophenone compounds to obtain 14 (E) ω-formylcamphene thiazole hydrazone compounds 5a-5n; the yields were all above 80%. The structures of the target compounds were characterized by IR, 1 H-NMR, 13 C-NMR, and HR-MS analyses. Then, 500, 250, 125, 62.5, and 31.25 mg/L drug solutions were prepared. Free radical scavenging experiments of 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and 2, 2-bis (3-ethyl-benzothiazole-6-sulfonic acid) diammonium salt (ABTS) were carried out with Trolox and L-ascorbic acid as the control samples. The scavenging rates of 14 compounds for DPPH and ABTS free radicals were obtained; the IC 50 values of scavenging free radicals were fitted using SPSS software. The results show that 14 (E) ω-formylcamphene-based thiazole hydrazone compounds exhibited good scavenging effects on the two free radicals, especially when the concentration of the drug solution was 125 and 62.5 mg/L; most compounds exceeded the scavenging efficiency of Trolox and L-ascorbic acid.

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Antioxidants of Natural Products

Abstract: Antioxidant ingredients are known to contribute to the beneficial effects of natural products in health promotion as well as disease prevention by reducing oxidative stress, caused by reactive oxygen or nitrogen species, in biological systems [...]

Cited by 7 publications

References 22 publications

Soybean Isoflavones Ameliorates Lactation Performance in Postpartum Mice by Alleviating Oxidative Stress and Regulating Gut Microflora

Soybean Isoflavones Ameliorates Lactation Performance in Postpartum Mice by Alleviating Oxidative Stress and Regulating Gut Microflora

Dynamic Microenvironment-Adaptable Hydrogel with Photothermal Performance and ROS Scavenging for Management of Diabetic Ulcer

Synthesis and Antioxidant Activity of (E) ω-Formylcamphene-Based Thiazole Hydrazone Derivatives

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