Antioxidants: Natural Antibiotics

Abstract

The aim of this current piece of writing is to draw the attention of readers and researchers toward the natural antioxidants that can take the place of synthetic antibiotics to avoid bacterial resistance and gastrotoxicity/nephrotoxicity. Antioxidants such as polyphenols, vitamins, and carotenoids are the organic compounds mainly extracted from natural sources and dominantly involved in boosting the defense system of organisms. The main public health-related issue over the globe is ever-growing bacterial resistance to synthetic antibiotics, which is being continuously reported during the last decade. Further, the pipeline of the development of new synthetic antibacterial agents to replace the resistant antibiotics in clinical setup is gradually drying up. This scenario originated the concept to revive the interest toward natural antibacterial products due to their chemical diversity, which provide important therapeutic effect and make the microbes unable to copy them for creating resistance. Natural products, especially polyphenols had been seen in antioxidant, antibacterial, anticancer, anti-inflammation, and antiviral activities with encouraging results. In this chapter, we will focus over the role of natural antioxidants as antibacterial agents.

Evaluation of Terminalia arjuna loaded in surfactant modified polycaprolactone nanofiber as an infection resistant matrix

“…These active antioxidant metabolites kill microbes by three mechanisms: inhibition of energy metabolism, disruption of cell membranes, and interruption in nucleic acid (DNA/RNA) synthesis (Figure 8b). 43 Hence, antioxidant activity inspection determines the potential of the developed NF as an antimicrobial product which is further ascertained by different antimicrobial tests.…”

In silico evaluation of natural bioactive compounds as Mycobacterium leprae enoyl acyl carrier protein reductase inhibitors

“…The selected ligands were downloaded from PubChem database (https://pubchem.ncbi.nlm.nih.gov) as SDF files and then converted to MOL2 using Open Babel software (http://openbabel.org) [19]. The considered ligands were selected upon antimicrobial bioactivity towards bacterial targets [16,17].…”

“…Previously, plenty of natural antioxidants and phytochemicals have proven their efficacy as antimicrobial agents. As compared to classical antibiotics, natural products and natural antioxidants exert their antibacterial action with no obvious resistance developed as well as less or no side effects noticed [16,17].…”

Insights into the Microbicidal, Antibiofilm, Antioxidant and Toxicity Profile of New O-Aryl-Carbamoyl-Oxymino-Fluorene Derivatives

“…In this context, the aim of this paper was to evaluate the antimicrobial features of new O-aryl-carbamoyl-oxymino-fluorene derivatives, previously reported for their inhibitory activity against Gram-positive (e.g., Bacillus anthracis , S. aureus , including methicillin resistant strains) and Gram-negative ( Escherichia coli , Proteus mirabilis , K. pneumoniae , P. aeruginosa , Burkholderiathailandensis and Francisella tularensis ) bacterial strains, mycobacteria, yeasts and molds [ 14 , 15 , 16 , 17 ]. The antioxidant activity of these compounds has been also evaluated, as it could represent an advantage for novel antimicrobial leads by decreasing the intensity and duration of the inflammatory response often accompanying the infectious process, thus avoiding their deleterious effects on the host tissues [ 18 ]. It is well known that oxidative stress represents an imbalance between the generation of free radicals and a decrease in the concentration of endogenous antioxidants (such as glutathione, vitamin C, vitamin E and a series of enzymes—catalase, superoxide dismutase and peroxidases) [ 19 ].…”