Antioxidants in patients receiving total parenteral nutrition after gastrointestinal cancer surgery

Abstract

Total parenteral nutrition (TPN) is essential for patients with postoperative impairing gastrointestinal function who are unable to receive and absorb oral/enteral feeding for at least 7 days. Oxidative stress plays a major role in the ethiopathogenesis of cancers. In this study, total antioxidant status (TAS), glutathione peroxidase (GPx), superoxide dismutase, malondialdehyde and ascorbic acid were studied in patients operated because of small intestine, colorectal or pancreatic cancer and subsequently receiving TPN in comparison with patients receiving standard nutrition after the operation. TAS level and GPx activity were decreased in patients with small intestine cancer but did not differ in patients with colorectal and pancreatic cancer before and after surgery. In all patient groups receiving TPN, superoxide dismutase activity after the surgery was kept at the same level as before. On the fifth day after the surgery, malondialdehyde concentration in each group was restored to the value observed before surgery. On the fifth day of TPN treatment, ascorbic acid concentration was increased in every group of patients. TPN applied during the postoperative period alleviates oxidative stress resulting from surgery. In the case of small intestine cancer, the addition of vitamins and antioxidants to the nutrition mixture seems to result in depletion of antioxidant enzymes' activities.

A Novel EphA2 Inhibitor Exerts Beneficial Effects in PI-IBS in Vivo and in Vitro Models via Nrf2 and NF-κB Signaling Pathways

“…Although the pathogenesis of PI-IBS is not well understood, a large body of evidence suggests that oxidative stress and inflammation play a pivotal role in the occurrence and persistence of its symptoms ( Akiho et al, 2010 ; Kaji et al, 2016 ). The imbalance of reactive oxygen species and antioxidant enzymes as well as the imbalance of proinflammatory cytokines and anti-inflammatory cytokines play a key role in the development of PI-IBS ( Szpetnar et al, 2012 ; Sundin et al, 2015 ). Consistent with these findings, we found that the levels of biomarkers of oxidative stress (4-HNE, protein carbonyl, and 8-OHdG), the expression of proinflammatory cytokines (TNF-α, IL-6, IL-17, and ICAM-1), and the activity of NF-κB were remarkably increased in the serum and colon of Trichinella spiralis -infected mice as well as LPS-treated NCM460 colonic cells.…”

GLP-2 Prevents Intestinal Mucosal Atrophy and Improves Tissue Antioxidant Capacity in a Mouse Model of Total Parenteral Nutrition

“…TPN administration can also cause a reactive oxygen species to be produced, and these peroxide contaminations could induce oxidative stress, leading to cell death [ 48 , 49 ]. Wesley et al .…”

Preoperative malnutrition in patients with colorectal cancer

“…The administration of postoperative total parenteral nutrition has been found to decrease the rate of further complications, improve antioxidant capacity, and improve nitrogen balance in cancer patients postoperatively. 37,38 Patients who received essential branched-chain amino acid support of leucine, isoleucine, and valine via total parenteral nutrition postoperatively were found to have an improved or more positive nitrogen balance despite the stress-induced catabolic state after surgery. 37 Furthermore, total parenteral nutrition administered in the postoperative period has been shown to alleviate oxidative stress ensuing from gastrointestinal surgery.…”