Antioxidants from the Brown Alga Dictyopteris undulata

Kumagai, Miho; Nishikawa, Keisuke; Matsuura, Hiroshi; Umezawa, Taiki; Matsuda, Fuyuhiko; Okino, Tatsufumi

doi:10.3390/molecules23051214

Cited by 20 publications

(13 citation statements)

References 28 publications

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“…Traditional extraction techniques for brown algae generally consist of maceration [9]; i.e., agitation of the algal material in solvents for a large number of hours at temperatures ranging from ambient to 50–60 °C [10,11]. Commonly used solvents include methanol [12], ethyl acetate (EtOAc) [13], dichloromethane [14], and ethanol [15] or their mixtures. As previous studies have mostly focused on specific brown algal metabolites rather than analysing the whole metabolome, the solvent of choice, extraction temperatures, and extraction time vary in the published literature.…”

Section: Introductionmentioning

confidence: 99%

Seasonal Variations in the Metabolome and Bioactivity Profile of Fucus vesiculosus Extracted by an Optimised, Pressurised Liquid Extraction Protocol

et al. 2018

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The metabolism of seaweeds depends on environmental parameters, the availability of nutrients, and biotic/abiotic stresses; therefore, their chemical composition fluctuates throughout the year. This study investigated seasonal variations in the metabolome of the Baltic Sea brown alga Fucus vesiculosus and its potential relation to the bioactivity profile. By using a definitive screening design (DSD) combined with pressurised liquid extraction (PLE), an optimised protocol was developed to extract algal biomass monthly for a full calendar year. An untargeted metabolomics approach using ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MSn)-based molecular networking and manual dereplication was employed. The extracts were simultaneously screened for their in vitro antimicrobial, anticancer/apoptotic, and free radical scavenging activities. 44 compounds were putatively dereplicated in the metabolome. Many compounds were found to vary with the sampling month; phlorotannin total ion count (TIC) was highest in summer, whilst chlorophylls, lipids, and carotenoids peaked in winter and spring. The greatest radical scavenging and apoptotic activities against pancreas cancer cells observed in the summer months were attributed to high phlorotannin TIC. Methicillin-resistant Staphylococcus aureus (MRSA) inhibitory activity was produced year-round without a clear seasonal trend. This is the first study applying DSD-based optimised PLE extraction combined with a metabolome analysis of F. vesiculosus for the identification of seasonal variations in both metabolome and bioactivity.

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Section: Introductionmentioning

confidence: 99%

Seasonal Variations in the Metabolome and Bioactivity Profile of Fucus vesiculosus Extracted by an Optimised, Pressurised Liquid Extraction Protocol

et al. 2018

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“…The DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging ability of the sample was conducted based on the method described by Kumagai et al [ 15 ] with minor modifications. The reaction mixture was with DPPH (0.1 mM, dissolved in ethanol) and various concentrations of sample in equal volumes, which was incubated at room temperature for 30 min in the dark.…”

Section: Methodsmentioning

confidence: 99%

Two New Altenusin/Thiazole Hybrids and a New Benzothiazole Derivative from the Marine Sponge-Derived Fungus Alternaria sp. SCSIOS02F49

Ya-ping

Chen

et al. 2018

Molecules

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Two novel altenusin-thiazole hybrids named altenusinoides A and B (1 and 2), a new benzothiazole derivative (3), and three known altenusin derivatives (4–6) have been obtained from the solid culture of the marine sponge-derived fungal strain, Alternaria sp. SCSIOS02F49. The structures of these new compounds were characterized by NMR, HRESIMS, and X-ray single crystal analysis. Compounds 1 and 2 possess an unusual altenusin-thiazole-fused skeleton core (6/6/5), and compound 3 represents the first benzothiazole derivative from fungi. Compounds 4 and 5 showed significant DPPH free-radical-scavenging activities with the prominent IC50 values of 10.7 ± 0.09 μM and 100.6 ± 0.025 μM, respectively. Additionally, compound 5 exhibited COX-2 inhibitory activity with an IC50 value of 9.5 ± 0.08 μM.

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“…Among all the antioxidant-rich phenolic compounds, phlorotannins, are widely found in macroalgae, especially in brown algae ( Montero et al, 2017 ). Fatty acids from Laurencia papillosa (red alga), sulfated polysaccharides from Pterocladia capillacea, meroterpenoids like sargachromanol, sargahydroquinoic and sargaquinoic acid from Sargassum serratifolium, sesquiterpenoids (isozonarol) from Dictyopteris undulata (brown alga) have been reported to exert high antioxidant property ( Fleita et al, 2015 ; Kumagai et al, 2018 ; Omar et al, 2018 ; Lim et al, 2019 ). Besides these, a range of edible seaweeds with antioxidative properties is consumed globally ( Table 2 ).…”

Section: Seaweeds As a Potential Source Of Antioxidantsmentioning

confidence: 99%

Medicinal Prospects of Antioxidants From Algal Sources in Cancer Therapy

Ferdous

Yusof

2021

Front. Pharmacol.

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Though cancer therapeutics can successfully eradicate cancerous cells, the effectiveness of these medications is mostly restricted to several deleterious side effects. Therefore, to alleviate these side effects, antioxidant supplementation is often warranted, reducing reactive species levels and mitigating persistent oxidative damage. Thus, it can impede the growth of cancer cells while protecting the normal cells simultaneously. Moreover, antioxidant supplementation alone or in combination with chemotherapeutics hinders further tumor development, prevents chemoresistance by improving the response to chemotherapy drugs, and enhances cancer patients’ quality of life by alleviating side effects. Preclinical and clinical studies have been revealed the efficacy of using phytochemical and dietary antioxidants from different sources in treating chemo and radiation therapy-induced toxicities and enhancing treatment effectiveness. In this context, algae, both micro and macro, can be considered as alternative natural sources of antioxidants. Algae possess antioxidants from diverse groups, which can be exploited in the pharmaceutical industry. Despite having nutritional benefits, investigation and utilization of algal antioxidants are still in their infancy. This review article summarizes the prospective anticancer effect of twenty-three antioxidants from microalgae and their potential mechanism of action in cancer cells, as well as usage in cancer therapy. In addition, antioxidants from seaweeds, especially from edible species, are outlined, as well.

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Antioxidants from the Brown Alga Dictyopteris undulata

Cited by 20 publications

References 28 publications

Seasonal Variations in the Metabolome and Bioactivity Profile of Fucus vesiculosus Extracted by an Optimised, Pressurised Liquid Extraction Protocol

Seasonal Variations in the Metabolome and Bioactivity Profile of Fucus vesiculosus Extracted by an Optimised, Pressurised Liquid Extraction Protocol

Two New Altenusin/Thiazole Hybrids and a New Benzothiazole Derivative from the Marine Sponge-Derived Fungus Alternaria sp. SCSIOS02F49

Medicinal Prospects of Antioxidants From Algal Sources in Cancer Therapy

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