Antioxidants for female subfertility

Showell, Marian; Mackenzie‐Proctor, Rebecca; Jordan, Vanessa; Hart, Roger

doi:10.1002/14651858.cd007807.pub4

Cited by 57 publications

(49 citation statements)

References 142 publications

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“…In addition, hGC viability increased up to 10 µM and estradiol secretion at 5 µM on both cell lines. However, more quality investigation in this area allied to clear evidence is needed, as it is pointed out by a COCHRANE meta-analysis on the impact of antioxidants on female infertility [52]. Interestingly, a novel approach on mitochondria targeting has been explored in recent years, based on molecules that disrupt its function.…”

Section: Discussionmentioning

confidence: 99%

Low Doses of Resveratrol Protect Human Granulosa Cells from Induced-Oxidative Stress

et al. 2021

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Resveratrol is a phytoalexin present in plant-derived foods, including grape’s skin, cocoa, and peanuts. Evidence suggests that it has beneficial effects on human health because of its antioxidant properties. However, there is limited knowledge about the part played by resveratrol in ovarian function. In this paper, the influence of resveratrol on granulosa cells (GC) was evaluated. In addition to being the main estradiol producers, GC are in direct contact with the oocyte, playing a fundamental role in its growth and development. The cell line COV434 and human granulosa cells (hGC), obtained from women undergoing assisted reproductive technology (ART), were used. GC were treated with resveratrol (0.001–20 μM) at different times (24–72 h). Low concentrations of this compound suggest a protective role, as they tend to reduce ROS/RNS formation after inducement of stress. On the contrary, high concentrations of resveratrol affect GC viability and steroidogenic function. As it may act as a direct modulator of GC oxidative balance, this work may help to clarify the impact of resveratrol on GC and the usefulness of this antioxidant as adjunct to infertility treatments.

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Section: Discussionmentioning

confidence: 99%

Low Doses of Resveratrol Protect Human Granulosa Cells from Induced-Oxidative Stress

et al. 2021

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“…DAs decrease serpin-1, reducing PAI-1. Pentoxifylline, a PAI-1 inhibitor, could increase pregnancy rates in women with endometriosis, although the evidence is of low quality [83]. Combining DAs that reduce the endometriosis lesion size while allowing for ovulation and pentoxifylline could be a novel approach to the medical treatment of endometriosis [81].…”

Section: Dopamine Agonistsmentioning

confidence: 99%

New Therapeutics in Endometriosis: A Review of Hormonal, Non-Hormonal, and Non-Coding RNA Treatments

Brichant

Laraki

Henry

et al. 2021

IJMS

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Endometriosis is defined as endometrial-like tissue outside the uterine cavity. It is a chronic inflammatory estrogen-dependent disease causing pain and infertility in about 10% of women of reproductive age. Treatment nowadays consists of medical and surgical therapies. Medical treatments are based on painkillers and hormonal treatments. To date, none of the medical treatments have been able to cure the disease and symptoms recur as soon as the medication is stopped. The development of new biomedical targets, aiming at the cellular and molecular mechanisms responsible for endometriosis, is needed. This article summarizes the most recent medications under investigation in endometriosis treatment with an emphasis on non-coding RNAs that are emerging as key players in several human diseases, including cancer and endometriosis.

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“…Some studies previously demonstrated that taking a multivitamin tablet, which includes acid folic and vitamins C, D, and E, may increase fertility. A cohort study demonstrated that antioxidants (different combinations of L-arginine, vitamin E, myoinositol, D-chiro-inositol, carnitine, selenium, vitamin B complex, vitamin C, vitamin D + calcium, Coenzyme Q10, and omega-3 polyunsaturated fatty acids) may improve clinical pregnancy rates when compared with a placebo or no treatment [176]. This suggested that, among subfertile women with an expected clinical pregnancy rate of 19%, the rate among women using antioxidants would be 25 and 30%.…”

Section: The Importance Of Female Reproductive Tract Protein and Non-protein Antioxidants In Fertility And Embryo Developmentmentioning

confidence: 99%

Antioxidants Present in Reproductive Tract Fluids and Their Relevance for Fertility

et al. 2021

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Nowadays, infertility is classified as a disease of the reproductive system. Although it does not compromise the life of the individual, it can have detrimental effects on the physiological and psychological health of the couple. Male fertility evaluation is mainly focused on the analysis of sperm parameters. However, the ejaculated fluid is also composed of seminal plasma, and the study of this fluid can provide crucial information to help in the assessment of male fertility status. Total antioxidant capacity of the seminal plasma has been positively correlated with the fertility of men. Moreover, evidence highlights to a similar importance as that of female reproductive tract fluid antioxidant capabilities and female fertility. Herein, we describe the functions of seminal plasma and female reproductive tract fluids, as well as their main antioxidant components and their relationships with fertility outcomes. Additionally, this review contains the most up to date information regarding the mechanisms of the interaction between the male and the female reproductive fluids and the importance of proper antioxidant capacity for fertilization.

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Antioxidants for female subfertility

Abstract: Analysis 3.1. Comparison 3 Pentoxifylline versus placebo or no treatment/standard care, Outcome 1 Live birth; pentoxifylline vs placebo or no treatment/standard treatment (natural conceptions and undergoing fertility treatments

Cited by 57 publications

References 142 publications

Low Doses of Resveratrol Protect Human Granulosa Cells from Induced-Oxidative Stress

Low Doses of Resveratrol Protect Human Granulosa Cells from Induced-Oxidative Stress

New Therapeutics in Endometriosis: A Review of Hormonal, Non-Hormonal, and Non-Coding RNA Treatments

Antioxidants Present in Reproductive Tract Fluids and Their Relevance for Fertility

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