Antioxidants: Basis concepts in relation to the eye

Abstract

Antioxidants are a small group of substances that protect living cells from the destructive consequences of powerful oxidizing intermediates that can be formed from oxygen. Situations in which pro-oxidant mechanisms within the body are more active than the antioxidant mechanisms (oxidative stress) predispose and contribute to the pathogenesis of several ailments in various organs of the body. In the eye, pro-oxidant factors have been blamed for the causation of diseases such as age related mecular degeneration and senile cataract. The role of pro.oxidants in the genesis of certain diseases is well established however, the effectivity of antioxidants provided to the body by dietary supplementation is inconclusive. In this article we provide a review on the basic concepts of antioxidant-pro-oxidant interaction in relation to its effects on the eye.

Assessment of oxidative stress and antioxidant status in age related cataract in a rural population

“…Oxidative stress is a term used to describe any challenge in which pro-oxidants predominate over antioxidants (1); it may be due to either increased production of reactive oxygen species (ROS) or decreased levels of antioxidants (enzymatic and nonenzymatic) or both. Oxidative stress is implicated in the etiopathogenesis of a variety of diseases like Cancer, Atherosclerosis, Cataract, Diabetes mellitus, Alzheimer's disease, Parkinson's disease etc.…”

Lipid Peroxidation a Nd Lipid Profile in Patients With Senile Cataract

“…It can be deduced from 9 . It may be due to either increased production of reactive oxygen species (ROS) or decreased levels of antioxidants (Enzymatic and Non enzymatic) or both.…”

Effects of limited access dressing in chronic wounds: A biochemical and histological study

“…In general, if these factors could be altered by any agent, an increased healing rate could be achieved. [4] Oxidative stress is a challenge in which pro-oxidants predominate over antioxidants; [5] it may be due to either increased production of reactive oxygen species (ROS) or decreased levels of antioxidants (enzymatic and non-enzymatic) or both. Oxidative stress, apart from affecting wound healing, is implicated in the aetiopathogenesis of variety of diseases like cardiovascular diseases, neurological diseases, malignancies, renal diseases, diabetes, inflammatory problems, skin diseases, etc.…”

“…[3] Limited access dressings (LAD), an innovation arising in our own country, is claimed to achieve the similar goals of NPWT with the added advantages of ability to inspect the wound at all times, being affordable and potential to be applicable in not-so-sophisticated settings. [4] That the reports of enhanced healing of problem wounds by LAD exist in the literature is beyond question, [4,5] what is interesting that the biochemical basis for healing of such wounds has been investigated. It seems intuitive that the LAD causes enhanced healing of the wounds because of increased healing potential.…”