Antioxidants as potential therapeutics for neuropsychiatric disorders

Pandya, Chirayu D.; Howell, Kristy R.; Pillai, Anilkumar

doi:10.1016/j.pnpbp.2012.10.017

Cited by 190 publications

(101 citation statements)

References 149 publications

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“…In contrast to aging, where the role of oxidative stress has been de‐emphasized in recent years, oxidative stress has been gaining increased attention as a pathogenic mechanism underlying several major psychiatric disorders, including psychosis and depression (Scapagnini et al ., 2012; Pandya et al ., 2013). Behavioral paradigms in rodents that are depressogenic (e.g., restraint stress, forced swim test) increase lipid peroxidation in several tissues (Sahin et al ., 2004; Lucca et al ., 2009; Runkel et al ., 2013; Spiers et al ., 2013).…”

Section: Introductionmentioning

confidence: 99%

Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non‐cell‐autonomous stress response

et al. 2015

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SummaryOxidative stress has long been associated with aging and has recently been linked to psychiatric disorders, including psychosis and depression. We identified multiple antipsychotics and antidepressants that extend Caenorhabditis elegans lifespan and protect the animal from oxidative stress. Here, we report that atypical antidepressants activate a neuronal mechanism that regulates the response to oxidative stress throughout the animal. While the activation of the oxidative stress response by atypical antidepressants depends on synaptic transmission, the activation by reactive oxygen species does not. Lifespan extension by atypical antidepressants depends on the neuronal oxidative stress response activation mechanism. Neuronal regulation of the oxidative stress response is likely to have evolved as a survival mechanism to protect the organism from oxidative stress, upon detection of adverse or dangerous conditions by the nervous system.

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Section: Introductionmentioning

confidence: 99%

Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non‐cell‐autonomous stress response

et al. 2015

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“…Different degrees of oxidetive damage and a decline in anti-oxidant enzymes have been reported in people with depression (Pandya et al, 2013). Use of anti-oxidant compounds such as nacetyl cysteine causes decrease in depression symptoms in people with depression.…”

Section: Biomarkers To Study Depressionmentioning

confidence: 99%

A review on antidepressant effect of medicinal plants

Rabiei

2017

Bangladesh J Pharmacol

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<p class="Abstract">Depression is a life-threatening, debilitating, and common disease affecting different segments of community. Chemical and synthetic drugs available to treat this disease cause many adverse effects and may lead to complete recovery in only 50% of patients. At the same time, medicinal plants have been reported to exert optimal pharmacological effects in treating depression in different models. In this review, the relevant articles indexed in the reliable databases PubMed, PubMed central, Scopus and Web of Science were review-ed. The review indicated that most medicinal plants exerted antidepressant effects through synaptic regulation of serotonin, noradrenaline, and dopamine, regulating activity of hypothalamic-pituitary-adrenal axis, reinfor-cing anti-oxidant defense system, and decreasing inflammatory mediators. The medicinal plants and their active compounds can relieve depression through different pathways and hence are considered a new source to produce antidepressants.</p>

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“…inflammation, oxidative stress and perhaps changes in steroids or in biogenic amine activity) are associated with, and may cause, telomere shortening. 45 Since such biochemical abnormalities cut across traditional psychiatric diagnoses [46][47][48] , telomere shortening may be related to specific biological processes or endophenotypes more than to specific diagnostic categories, although this remains to be adequately tested. This could help explain the inconsistency of LTL findings in specific diagnostic groups and the heterogeneity of findings among different diagnostic groups.…”

Section: IVmentioning

confidence: 99%

Telomeres And Early Life Stress: A Review

Singh¹,

Y.R²,

Majumder³

et al. 2017

IOSR JDMS

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I. Stress, Coping And AgingIndividuals differ in their psychological and biological responses to stress. In particular, an individual"s appraisal or assessment of a specific psychological stressor determines their cognitive-emotional response, which in turn influences their biological response and hence the extent to which the stressor has the potential to "get under the skin" to influence physical health.1 According to the classic Lazarus and Folkman "Transactional Model of Stress and Coping", individuals who perceive that a stressor exceeds their resources to cope effectively will appraise the situation as threatening and exhibit a response characterized by threat-related cognitions and emotions such as worry and fear. In contrast, individuals who perceive that they have adequate resources to cope with a stressor will appraise it as challenging and exhibit a response characterized by challenge related cognitions and emotions such as perceived control and excitement.2 Subsequent research has shown that biological reactions to stressors appraised as threatening differ from those appraised as challenging, and that the former are associated with more harmful physiological reactions than are the latter .The biological response to stress involves the coordinated activity of several systems, including the hypothalamic-pituitary-adrenal (HPA) axis, the sympathetic nervous system, and the immune system. Acute activation of these systems serves to mobilize energy resources and prepare the individual for coping with stressors. With chronic stress exposure, however, attempts at adaptation can result in pathological perturbation of endocrine, immune, and metabolic systems. 3,4 There is possibility that certain psychiatric illnesses are associated with accelerated biological aging at cellular level. Whereas chronological age is measured in calendar units, biological age is defined physiologically and is more closely associated with disease processes. "Accelerated biological aging" occurs when biological age outpaces chronological age. II. TelomeresTelomeres (from the Greek telos [end] and meros [part]) are DNA-protein complexes at the ends of chromosomes, composed of tandem TTAGGG repeats ranging from a few to 15 kilobases in length mainly protecting chromosomes from damage. Telomeres shorten with repeated cell divisions in somatic cells due to incomplete replication of the telomere ends, replication and nuclease-associated telomeric DNA damage, and/or chronic exposure to oxidation, certain cytotoxins or inflammation and possibly chronic exposure to the stress hormones, cortisol and catecholamine.5 When telomeres reach a critically short length, cells undergo replicative senescence or can become genomically unstable.Leukocyte telomere length generally decreases progressively over the lifespan, with estimates of average attrition rate ranging between 14 to 103 base pairs (bp) per year (weighted mean of 21.9 bp per year) in cross-sectional studies, and between 32.2 to 45.5 bp per year (weighted mean of 40.7 bp per year) in lo...

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Antioxidants as potential therapeutics for neuropsychiatric disorders

Cited by 190 publications

References 149 publications

Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non‐cell‐autonomous stress response

Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non‐cell‐autonomous stress response

A review on antidepressant effect of medicinal plants

Telomeres And Early Life Stress: A Review

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