Antioxidants and the Response of Skin to Oxidative Stress: Vitamin E as a Key Indicator

Packer, Lester; Valacchi, Giuseppe

doi:10.1159/000064531

Cited by 112 publications

(87 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results are in line with previous published studies that examined the effect of air pollution on skin diseases and, more specifically, on cellulitis [19][20][21][22][23]. As cellulitis is caused by various bacteria, it has been proposed to identify the bacteria levels in diagnosis of patients.…”

Section: Cellulitissupporting

confidence: 89%

“…Moreover exposure to ambient O 3 has been associated with skin stress-responses and also various skin conditions [17][18][19][20] including cellulitis [21,22]. Human skin acts as a protective and active biological shield against pro-oxidative chemical products and air pollutants [23]. Exposure of the skin to ambient air pollution may have negative impact on the skin health condition and affect skin homeostasis.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ambient air pollution and emergency department visits for skin conditions

Szyszkowicz¹,

Kousha²,

Valacchi³

2016

Glob Dermatol

Self Cite

View full text Add to dashboard Cite

that ambient air pollution exposure may affect skin barrier function and allow exogenous bacteria to penetrate in the cutaneous tissues. In addition, recent studies have documented a strong correlation between cellulitis and ozone exposure for the parts of cutaneous tissues that are less covered by clothes [21]. The hypothesis that stronger associations for cellulitis are observed in area that are in direct contact with air pollutants was proposed and verified by the first author of this work [21].In this study, a case-crossover (CC) technique was used to evaluate any potential association between emergency department ED visits for cellulitis and other skin conditions with ambient air pollution [25]. The CC method allows to adjust the results for time trend and the seasonal variability. ED visits for a wide range of skin conditions, including urticaria (hives), cellulitis, dermatitis and rashes, were used to represent health outcomes. The CC method was realized on clusters defined by individual cases-control strata to avoid potential bias [26].This work assesses potential impacts of ambient air pollution to human skin condition development. From our data we can propose that increase in ambient air pollution levels can exacerbate various health conditions, among them the ones related to skin as well. In addition, it is possible that skin chronic exposure to air pollution can IntroductionThe human skin is the body's first and main barrier of defense against environmental stressors such as air pollution and ultraviolet irradiation (UV) [1]. The upper layer of the epidermis is mainly one of the first and major targets of air pollutants. Ground-level ozone (O 3 ) is one of the most reactive environmental oxidants and the main component of photochemical smog. Many studies have shown that O 3 affects respiratory health [2][3][4][5][6][7][8][9][10][11], is a risk factor for respiratory conditions such as asthma [12,13] and may even be linked to nonrespiratory conditions [13][14][15][16]. Moreover exposure to ambient O 3 has been associated with skin stress-responses and also various skin conditions [17][18][19][20] including cellulitis [21,22]. Human skin acts as a protective and active biological shield against pro-oxidative chemical products and air pollutants [23]. Exposure of the skin to ambient air pollution may have negative impact on the skin health condition and affect skin homeostasis.In this study short-term exposure to ambient air pollution is considered. The aim of this study was to investigate potential correlation between ambient air pollution exposures, especially ozone, and emergency department (ED) visits for skin conditions during the period from April 2004 to December 2011 in nine cities across the province of Ontario, Canada: Algoma (district), Halton (municipality), Hamilton, London, Ottawa, Peel (municipality), Toronto, Windsor and York. It has been shown that results from multi-city studies are more reliable and are less susceptible to biases than those from single locations [24].In this study ED...

show abstract

Section: Cellulitissupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Ambient air pollution and emergency department visits for skin conditions

Szyszkowicz¹,

Kousha²,

Valacchi³

2016

Glob Dermatol

Self Cite

View full text Add to dashboard Cite

show abstract

“…Alpha-tocopherol is a major skin antioxidant (31) that is secreted through the sebaceous glands, and high concentrations are observed in the outer skin layers (32). Decrease in vitamin E has also been linked by earlier investigations to skin disorders (31). Lipid peroxidation is thought to play an important role in the pathogenesis of acne (33).…”

Section: Discussionmentioning

confidence: 92%

Serum Retinol, Alpha-Tocopherol and Systemic Inflammatory Response in Metastatic Colorectal Carcinoma Patients Treated with Combination Chemotherapy and Cetuximab

Melichar

Krčmová

Kalábová

et al. 2010

J Nutr Sci Vitaminol

View full text Add to dashboard Cite

Summary Cetuximab is a chimeric antibody registered for the therapy of advanced colorectal carcinoma. Cancer and anticancer therapy are associated with oxidative stress, and disorders of antioxidant balance may be involved in the toxicity associated with anticancer treatment. The aim of the present study was to investigate the changes of serum retinol, alpha-tocopherol and C-reactive protein during the first month of treatment with cetuximab and chemotherapy. Twenty-five consecutive patients with metastatic colorectal carcinoma treated with a combination of chemotherapy and cetuximab were included in the present study. Serum retinol and alpha-tocopherol were determined by high-performance liquid chromatography and serum C-reactive protein was determined using commercial kits. Significant correlation was observed between baseline concentrations of retinol and C-reactive protein ( r s ϭϪ 0.54, p Ͻ 0.01). Median survival of patients who had baseline serum retinol below 1.25 mol/L was 10 mo compared to 18 mo for patients who had serum retinol equal or above 1.25 mol/L ( p Ͻ 0.05); median survival of patients who had serum C-reactive protein below 24 mg/L was significantly longer compared to patients with C-reactive protein levels equal or above 24 mg/L (18 vs. 7 mo, p Ͻ 0.05), but no difference in survival was observed based on alpha-tocopherol levels. Twenty-two patients had evaluation of retinol, alpha-tocopherol and C-reactive protein at least once during the follow up. Serum concentration of alpha-tocopherol decreased significantly during the therapy, but retinol and Creactive protein concentrations remained unchanged. In conclusion, a significant correlation was observed between serum retinol and C-reactive protein. Serum alpha-tocopherol decreased significantly during the first month of combination therapy with cetuximab. Low retinol and high C-reactive protein concentrations were predictive of poor prognosis in this patient population.

show abstract

“…S. marianum seed oil contains silymarin flavonoids including silibinin, silidianin and silichrystin, which may exert antioxidative activity (15), and show potential anti-aging effects as a cosmetic cream formulation by decreasing transepidermal water loss and surface wrinkles (16). Vitamin E has been demonstrated to be an antioxidant in numerous studies (17)(18)(19). Additionally, cosmetic application of vitamin E protects skin from ultraviolet (UV) damage, which may exacerbate wrinkles, loss of elasticity and dehydration (20)(21)(22).…”

Section: Introductionmentioning

confidence: 99%

Instrumental evaluation of anti-aging effects of cosmetic formulations containing palmitoyl peptides, Silybum marianum seed oil, vitamin E and other functional ingredients on aged human skin

Hahn

Jung

Schrammek-Drusios³

et al. 2016

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. Anti-aging cosmetics are widely used for improving signs of aged skin such as skin wrinkles, decreased elasticity, low dermal density and yellow skin tone. The present study evaluated the effects of cosmetic formulations, eye cream and facial cream, containing palmitoyl peptides, Silybum marianum (S. marianum) seed oil, vitamin E and other functional ingredients on the improvement of facial wrinkles, elasticity, dermal density and skin tone after 4 weeks period of application on aged human skin. Healthy volunteers (n=20) with aged skin were recruited to apply the test materials facially twice per day for 4 weeks. Skin wrinkles, elasticity, dermal density and skin tone were measured instrumentally for assessing the improvement of skin aging. All the measurements were conducted prior to the application of test materials and at 2 and 4 weeks of treatment. Crow's feet wrinkles were decreased 5.97% after 2 weeks of test material application and 14.07% after 4 weeks of application in comparison of pre-application. Skin elasticity was increased 6.81% after 2 weeks and 8.79% after 4 weeks. Dermal density was increased 16.74% after 2 weeks and 27.63% after 4 weeks. With the L * value indicating skin brightness and the a * value indicating erythema (redness), the results showed that brightness was increased 1.70% after 2 weeks and 2.14% after 4 weeks, and erythema was decreased 10.45% after 2 weeks and 22.39% after 4 weeks. Hence, the test materials appear to exert some degree of anti-aging effects on aged human skin. There were no abnormal skin responses from the participants during the trial period. We conclude that the facial and eye cream containing palmitoyl peptides and S. marianum seed oil, vitamin E and other ingredients have effects on the improvement of facial wrinkles, elasticity, dermal density and skin tone.

show abstract

Antioxidants and the Response of Skin to Oxidative Stress: Vitamin E as a Key Indicator

Cited by 112 publications

References 49 publications

Ambient air pollution and emergency department visits for skin conditions

Ambient air pollution and emergency department visits for skin conditions

Serum Retinol, Alpha-Tocopherol and Systemic Inflammatory Response in Metastatic Colorectal Carcinoma Patients Treated with Combination Chemotherapy and Cetuximab

Instrumental evaluation of anti-aging effects of cosmetic formulations containing palmitoyl peptides, Silybum marianum seed oil, vitamin E and other functional ingredients on aged human skin

Contact Info

Product

Resources

About