Antioxidants and Shelf Life of Foods

Eskin, N.A.M.; Przybylski, Rémi

doi:10.1201/9781420036657.ch6

Cited by 18 publications

(20 citation statements)

References 1 publication

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“…The germ portion of the seed typically contains 30% oil [27], therefore removal of the oil can significantly concentrate the HBsAg in the germ and extend its shelf life [28]. To determine whether oil removal can impact the immune response, the germ was ground and differentially processed by hexane treatment, supercritical fluid extraction (SFE) treatment, or no treatment (full fat).…”

Section: Resultsmentioning

confidence: 99%

Supercritical fluid extraction provides an enhancement to the immune response for orally-delivered hepatitis B surface antigen

Hayden

Smith

Turner

et al. 2014

Vaccine

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The hepatitis B virus continues to be a major pathogen worldwide despite the availability of an effective parenteral vaccine for over 20 years. Orally-delivered subunit vaccines produced in maize may help to alleviate the disease burden by providing a low-cost, heat stable alternative to the parenteral vaccine. Oral subunit vaccination has been an elusive goal due to the large amounts of antigen required to induce an immunologic response when administered through the digestive tract. Here we show that high levels of HBsAg were obtained in maize grain, the grain was formed into edible wafers, and wafers were fed to mice at a concentration of approximately 300µg/g. When these wafers were made with supercritical fluid extraction (SFE)-treated maize material, robust IgG and IgA responses in sera were observed that were comparable to the injected commercial vaccine Recombivax®). In addition, all mice administered SFE wafers showed high secretory IgA titers in fecal material whereas Recombivax® treated mice showed no detectable titer. Increased salivary IgA titers were also detected in SFE-fed mice but not in Recombivax® treated mice. Wafers made from hexane-treated, or full fat, maize material induced immunologic responses, but fecal titers were attenuated relative to those produced by SFE-treated wafers. These responses demonstrate the feasibility of using a two-dose oral vaccine booster in the absence of an adjuvant to induce immunologic responses in both sera and at mucosal surfaces, and highlight the potential limitations of using an exclusively parenteral dosing regime.

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Section: Resultsmentioning

confidence: 99%

Supercritical fluid extraction provides an enhancement to the immune response for orally-delivered hepatitis B surface antigen

Hayden

Smith

Turner

et al. 2014

Vaccine

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show abstract

“…This oxidation can be initiated by factors such as light, temperature, enzymes, metals, metalloproteins and microorganisms. During oxidation free radicals are generated, unsaturated lipids and oxygen are primary substrates for developing this reaction (Eskin and Przybylski, 2001). 2-Methylpropanal, n-pentanal, n-hexanal and heptanal have been reported to be responsible for alteration of milk flavour (Cadwallader and Howard, 1998).…”

Section: Introductionmentioning

confidence: 99%

Release of antioxidants from co-extruded active packaging developed for whole milk powder

Granda-Restrepo

Peralta

Troncoso‐Rojas

et al. 2009

International Dairy Journal

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“…Lipid oxidation can be initiated by factors such as light, temperature, enzymes, metals, metalloproteins and microorganisms. During oxidation free radicals are generated, unsaturated lipids and oxygen are primary substrates for developing this reaction (Eskin & Przybylski, 2001). 2-Methylpropanal, n-pentanal, n-hexanal and heptanal have been reported to be responsible for alteration of milk flavor (Cadwallader & Howard, 1998).…”

Section: Introductionmentioning

confidence: 99%